Brimonidine prevents axonal and somatic degeneration of retinal ganglion cell neurons (Q33792600)

29 July 2017

title

Brimonidine prevents axonal and somatic degeneration of retinal ganglion cell neurons (English)

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29 July 2017

main subject

retinal ganglion cell

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Wendi S Lambert

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29 July 2017

Lupe Ruiz

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29 July 2017

Samuel D Crish

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29 July 2017

Larry A Wheeler

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29 July 2017

David J Calkins

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29 July 2017

publication date

13 January 2011

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Molecular Neurodegeneration

29 July 2017

published in

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29 July 2017

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29 July 2017

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29 July 2017

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Retinal Ganglion Cell Loss in a Rat Ocular Hypertension Model Is Sectorial and Involves Early Optic Nerve Axon Loss

29 July 2017

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4 July 2018

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4 July 2018

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4 July 2018

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4 July 2018

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4 July 2018

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4 July 2018

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4 July 2018

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4 July 2018

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4 July 2018

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4 July 2018

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4 July 2018

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An electrophysiological study of the visual projection to the superior colliculus of the rat

4 July 2018

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4 July 2018

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Reaction of Müller cells in an experimental rat model of increased intraocular pressure following timolol, latanoprost and brimonidine

4 July 2018

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Retinal oxidative stress induced by intraocular hypertension in rats may be ameliorated by brimonidine treatment and N-acetyl cysteine supplementation

30 October 2018

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Clinical efficacy and neuroprotective effects of brimonidine in the management of glaucoma and ocular hypertension.

30 October 2018

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Effect of brimonidine on retinal ganglion cell survival in an optic nerve crush model

30 October 2018

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Alpha2 adrenergic modulation of NMDA receptor function as a major mechanism of RGC protection in experimental glaucoma and retinal excitotoxicity

30 October 2018

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Progressive ganglion cell degeneration precedes neuronal loss in a mouse model of glaucoma

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3035592

Retinal ganglion cells downregulate gene expression and lose their axons within the optic nerve head in a mouse glaucoma model.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3035592

Localization of alpha 2 receptors in ocular tissues

30 October 2018

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Neuroprotective effect of topically applied brimonidine tartrate 0.2% in endothelin-1-induced optic nerve ischaemia model

30 October 2018

1 reference

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Alpha2 adrenergic receptor-mediated modulation of cytosolic Ca++ signals at the inner plexiform layer of the rat retina

30 October 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3035592

Quantitative correlation of optic nerve pathology with ocular pressure and corneal thickness in the DBA/2 mouse model of glaucoma

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3035592

Retinal ganglion cell degeneration is topological but not cell type specific in DBA/2J mice

30 October 2018

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30 October 2018

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Ischemia results 3 months later in altered ERG, degeneration of inner layers, and deafferented tectum: neuroprotection with brimonidine

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3035592

Transient ischemia of the retina results in massive degeneration of the retinotectal projection: long-term neuroprotection with brimonidine

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3035592

Intrinsic activation of PI3K/Akt signaling pathway and its neuroprotective effect against retinal injury

30 October 2018

1 reference

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Alpha-2 adrenoceptor agonist protects retinal function after acute retinal ischemic injury in the rat.

30 October 2018

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30 October 2018

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30 October 2018

1 reference

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Neuroprotective effect of alpha(2) agonist (brimonidine) on adult rat retinal ganglion cells after increased intraocular pressure

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3035592

Role of alpha-2 adrenergic receptors in neuroprotection and glaucoma

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3035592

Retinal ganglion cell death induced by retinal ischemia. neuroprotective effects of two alpha-2 agonists

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3035592

Glycogen synthase kinase 3beta phosphorylation of microtubule-associated protein 1B regulates the stability of microtubules in growth cones.

30 October 2018

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Alpha2-adrenoreceptor agonists are neuroprotective in a rat model of optic nerve degeneration

30 October 2018

1 reference

12 December 2020

Nerve growth factor-dependent activation of NF-kappaB contributes to survival of sympathetic neurons

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12 December 2020

Phosphorylation of Neurofilament Heavy‐Chain Side‐Arm Fragments by Cyclin‐Dependent Kinase‐5 and Glycogen Synthase Kinase‐3α in Transfected Cells

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12 December 2020

Alpha-2 adrenoceptor mediated changes in aqueous dynamics: effect of pertussis toxin

1 reference

12 December 2020

The Advanced Glaucoma Intervention Study (AGIS): 7. The relationship between control of intraocular pressure and visual field deterioration.The AGIS Investigators

1 reference

12 December 2020

Brain-derived neurotrophic factor-mediated neuroprotection of adult rat retinal ganglion cells in vivo does not exclusively depend on phosphatidyl-inositol-3'-kinase/protein kinase B signaling

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12 December 2020

Identifiers

DOI

10.1186/1750-1326-6-4

1 reference

Dimensions Publication ID

29 July 2017

0 references

1 reference

29 July 2017

1 reference