Glutathione and trypanothione in parasitic hydroperoxide metabolism (Q33777935)

29 July 2017

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title

Glutathione and trypanothione in parasitic hydroperoxide metabolism (English)

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29 July 2017

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Flohé L

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29 July 2017

Hecht HJ

series ordinal

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29 July 2017

Steinert P

series ordinal

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29 July 2017

publication date

1 November 1999

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Free Radical Biology and Medicine

29 July 2017

published in

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29 July 2017

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29 July 2017

issue

9-10

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29 July 2017

page(s)

966-984

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Tissue-specific functions of individual glutathione peroxidases

29 July 2017

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Antimalarial cyclic peroxy ketals

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Correlation of antimalarial activity of artemisinin derivatives with binding affinity with ferroprotoporphyrin IX

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Dispiro-1,2,4,5-tetraoxanes: a new class of antimalarial peroxides

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7 January 2021

The effect of ascaridole on the in vitro development of Plasmodium falciparum.

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7 January 2021

Antioxidant defense mechanisms in parasitic protozoa

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7 January 2021

Evidence for a neutrophil-mediated protective response in malaria

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7 January 2021

Effect of nifedipine on oxidative damage of erythrocytes in Plasmodium berghei-infected mice

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7 January 2021

Susceptibility of Plasmodium falciparum to a peroxidase-mediated oxygen-dependent microbicidal system

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7 January 2021

Detection of short-chain carbonyl products of lipid peroxidation from malaria-parasite (Plasmodium vinckei)-infected red blood cells exposed to oxidative stress

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7 January 2021

Increased levels of 4-hydroxynonenal in human monocytes fed with malarial pigment hemozoin. A possible clue for hemozoin toxicity.

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7 January 2021

Formation of hydroxyeicosatetraenoic acids from hemozoin-catalyzed oxidation of arachidonic acid

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7 January 2021

The redox status of malaria-infected erythrocytes: an overview with an emphasis on unresolved problems

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7 January 2021

Molecular basis for selective advantage of glucose-6-phosphate-dehydrogenase-deficient individuals exposed to malaria

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7 January 2021

Plasmodium falciparum: thiol status and growth in normal and glucose-6-phosphate dehydrogenase deficient human erythrocytes

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7 January 2021

Flow cytometric assessment of oxidant stress in age-fractionated thalassaemic trait erythrocytes and its relationship to in vitro growth of Plasmodium falciparum.

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7 January 2021

Deleterious synergistic effects of ascorbate and copper on the development of Plasmodium falciparum: an in vitro study in normal and in G6PD-deficient erythrocytes

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7 January 2021

Killing of Plasmodium falciparum by human monocyte-derived macrophages

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7 January 2021

The malaria parasite supplies glutathione to its host cell--investigation of glutathione transport and metabolism in human erythrocytes infected with Plasmodium falciparum

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7 January 2021

Plasmodium falciparum glutathione metabolism and growth are independent of glutathione system of host erythrocyte

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7 January 2021

Plasmodium falciparum glutathione reductase exhibits sequence similarities with the human host enzyme in the core structure but differs at the ligand-binding sites

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7 January 2021

Recombinant putative glutathione reductase of Plasmodium falciparum exhibits thioredoxin reductase activity

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7 January 2021

Identification and Characterization of the Functional Amino Acids at the Active Site of the Large Thioredoxin Reductase fromPlasmodium falciparum

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7 January 2021

Molecular cloning and characterization of a putative glutathione reductase gene, the PfGR2 gene, from Plasmodium falciparum

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7 January 2021

Oxidant defense enzymes of Plasmodium falciparum

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7 January 2021

Molecular characterization of the glutathione peroxidase gene of the human malaria parasite Plasmodium falciparum.

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7 January 2021

Increase in glutathione peroxidase activity in malaria parasite after selenium supplementation.

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7 January 2021

Babesia hylomysci and B. divergens: presence of antioxidant enzymes destroying hydrogen peroxide

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7 January 2021

Purification and properties of a recombinant sulfur analog of murine selenium-glutathione peroxidase

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7 January 2021

Probing the presumed catalytic triad of selenium-containing peroxidases by mutational analysis of phospholipid hydroperoxide glutathione peroxidase (PHGPx).

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7 January 2021

Identification of a novel, thiol-containing co-factor essential for glutathione reductase enzyme activity in trypanosomatids.

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7 January 2021

Overexpression of superoxide dismutase in Trypanosoma cruzi results in increased sensitivity to the trypanocidal agents gentian violet and benznidazole

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7 January 2021

Molecular cloning and characterization of two iron superoxide dismutase cDNAs from Trypanosoma cruzi

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7 January 2021

Molecular cloning, characterization, and expression in Escherichia coli of iron superoxide dismutase cDNA from Leishmania donovani chagasi.

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7 January 2021

Cloning, characterization and overexpression of two iron superoxide dismutase cDNAs from Leishmania chagasi: role in pathogenesis

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7 January 2021

Leishmanial glycosomes contain superoxide dismutase

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7 January 2021

[5] Diversity of glutathione peroxidases

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7 January 2021

Deficient metabolic utilization of hydrogen peroxide in Trypanosoma cruzi

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7 January 2021

Trypanosoma cruzi: a 52-kDa protein sharing sequence homology with glutathione S-transferase is localized in parasite organelles morphologically resembling reservosomes

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7 January 2021

Catalytic and potentiometric characterization of E201D and E201Q mutants of Trypanosoma congolense trypanothione reductase

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7 January 2021

Subcellular distribution of trypanothione reductase in bloodstream and procyclic forms of Trypanosoma brucei.

1 reference

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7 January 2021

Biosynthesis of the trypanosomatid metabolite trypanothione: purification and characterization of trypanothione synthetase from Crithidia fasciculata

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7 January 2021

Purification of glutathionylspermidine and trypanothione synthetases from Crithidia fasciculata

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7 January 2021

Convenient isolation and kinetic mechanism of glutathionylspermidine synthetase from Crithidia fasciculata

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7 January 2021

Glutathionylspermidine metabolism in Escherichia coli. Purification, cloning, overproduction, and characterization of a bifunctional glutathionylspermidine synthetase/amidase

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7 January 2021

Cloning and characterization of the two enzymes responsible for trypanothione biosynthesis in Crithidia fasciculata

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7 January 2021

Phosphonic acid and phosphinic acid tripeptides as inhibitors of glutathionylspermidine synthetase

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7 January 2021

The Achilles' heel of trypanosomatids: trypanothione-mediated hydroperoxide metabolism

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7 January 2021

Purification and characterization of lipoamide dehydrogenase from Trypanosoma cruzi

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7 January 2021

Evidence for the co-existence of glutathione reductase and trypanothione reductase in the non-trypanosomatid Euglenozoa: Euglena gracilis Z

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7 January 2021

Trypanothione reductase from Trypanosoma cruzi. Purification and characterization of the crystalline enzyme.

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7 January 2021

Initiating a crystallographic study of trypanothione reductase

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7 January 2021

X-ray structure of trypanothione reductase from Crithidia fasciculata at 2.4-A resolution

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7 January 2021

Site-directed mutagenesis of the redox-active cysteines of Trypanosoma cruzi trypanothione reductase.

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7 January 2021

Ajoene is an inhibitor and subversive substrate of human glutathione reductase and Trypanosoma cruzi trypanothione reductase: crystallographic, kinetic, and spectroscopic studies

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7 January 2021

Substrate interactions between trypanothione reductase and N1-glutathionylspermidine disulphide at 0.28-nm resolution

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7 January 2021

Glutathione reductase turned into trypanothione reductase: structural analysis of an engineered change in substrate specificity

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7 January 2021

Crystal structure of the Trypanosoma cruzi trypanothione reductase.mepacrine complex

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7 January 2021

Substrate binding and catalysis by glutathione reductase as derived from refined enzyme: substrate crystal structures at 2 A resolution

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7 January 2021

Phenotype of recombinant Leishmania donovani and Trypanosoma cruzi which over-express trypanothione reductase. Sensitivity towards agents that are thought to induce oxidative stress.

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7 January 2021

Down-regulation of Leishmania donovani trypanothione reductase by heterologous expression of a trans-dominant mutant homologue: effect on parasite intracellular survival

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7 January 2021

Disruption of the trypanothione reductase gene of Leishmania decreases its ability to survive oxidative stress in macrophages.

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7 January 2021

Trypanosoma brucei tryparedoxin, a thioredoxin-like protein in African trypanosomes.

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7 January 2021

Sequence, heterologous expression and functional characterization of tryparedoxin1 from Crithidia fasciculata

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7 January 2021

Cloning, expression and reconstitution of the trypanothione-dependent peroxidase system of Crithidia fasciculata

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7 January 2021

Thioredoxin and thioredoxin reductase

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7 January 2021

Preparation and assay of mammalian thioredoxin and thioredoxin reductase

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7 January 2021

Catalytic Characteristics of Tryparedoxin

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7 January 2021

Crystal structures of reduced, oxidized, and mutated human thioredoxins: evidence for a regulatory homodimer

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7 January 2021

Crystallization and preliminary X-ray analysis of tryparedoxin I from Crithidia fasciculata

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7 January 2021

Activation of active-site cysteine residues in the peroxiredoxin-type tryparedoxin peroxidase of Crithidia fasciculata

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7 January 2021

Crystal structure of a novel human peroxidase enzyme at 2.0 A resolution

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7 January 2021

The refined structure of the selenoenzyme glutathione peroxidase at 0.2-nm resolution

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https://api.crossref.org/works/10.1016%2FS0891-5849%2899%2900172-0

7 January 2021

Cytoplasmic localization of the trypanothione peroxidase system in Crithidia fasciculata

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7 January 2021

Identification and characterisation of a functional peroxidoxin from Leishmania major

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7 January 2021

Trypanosoma cruzi: immunolocalization of trypanothione reductase

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7 January 2021

Respiratory chain linked H(2)O(2) production in pigeon heart mitochondria

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7 January 2021

Possible role of the NADH-fumarate reductase in superoxide anion and hydrogen peroxide production in Trypanosoma brucei

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7 January 2021

Hydrogen peroxide generation inTrypanosoma cruzi

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7 January 2021

Succinate-dependent metabolism in Trypanosoma cruzi epimastigotes

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7 January 2021

Cloning and characterization of the gene encoding Schistosoma mansoni glutathione peroxidase

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7 January 2021

Exhaustive matching of the entire protein sequence database

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7 January 2021

Isoforms of mammalian peroxiredoxin that reduce peroxides in presence of thioredoxin

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7 January 2021

Removal of hydrogen peroxide by thiol-specific antioxidant enzyme (TSA) is involved with its antioxidant properties. TSA possesses thiol peroxidase activity.

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7 January 2021

Amphibacillus xylanus NADH oxidase and Salmonella typhimurium alkyl-hydroperoxide reductase flavoprotein components show extremely high scavenging activity for both alkyl hydroperoxide and hydrogen peroxide in the presence of S. typhimurium alkyl-hy

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7 January 2021

Requirement for the Two AhpF Cystine Disulfide Centers in Catalysis of Peroxide Reduction by Alkyl Hydroperoxide Reductase

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7 January 2021

Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence

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7 January 2021

Identification of an Entamoeba histolytica gene encoding a protein homologous to prokaryotic disulphide oxidoreductases

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https://api.crossref.org/works/10.1016%2FS0891-5849%2899%2900172-0

7 January 2021

Removal of hydrogen peroxide by the 29 kDa protein of Entamoeba histolytica

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https://api.crossref.org/works/10.1016%2FS0891-5849%2899%2900172-0

7 January 2021

Peroxidase activity of a TSA-like antioxidant protein from a pathogenic amoeba

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7 January 2021

Thioredoxin peroxidase from Onchocerca volvulus: a major hydrogen peroxide detoxifying enzyme in filarial parasites

1 reference

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7 January 2021

The peroxidoxin 2 protein of the human parasite Onchocerca volvulus: recombinant expression, immunolocalization, and demonstration of homologous molecules in other species

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7 January 2021

Molecular cloning, expression and enzymatic activity of a thioredoxin peroxidase from Dirofilaria immitis

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7 January 2021

Thioredoxin peroxidases from Brugia malayi

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https://api.crossref.org/works/10.1016%2FS0891-5849%2899%2900172-0

7 January 2021

Cloning of peroxiredoxin, a novel antioxidant enzyme, from the helminth parasite Fasciola hepatica

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https://api.crossref.org/works/10.1016%2FS0891-5849%2899%2900172-0

7 January 2021

The human homologue of a bovine non-selenium glutathione peroxidase is a novel keratinocyte growth factor-regulated gene

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https://api.crossref.org/works/10.1016%2FS0891-5849%2899%2900172-0

7 January 2021

A novel type of glutathione peroxidase: expression and regulation during wound repair

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7 January 2021

Human T cell cyclophilin18 binds to thiol-specific antioxidant protein Aop1 and stimulates its activity

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7 January 2021

Regulatory Role for a Novel Human Thioredoxin Peroxidase in NF-κB Activation

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7 January 2021

Mammalian peroxiredoxin isoforms can reduce hydrogen peroxide generated in response to growth factors and tumor necrosis factor-alpha.

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7 January 2021

A family of novel peroxidases, peroxiredoxins

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7 January 2021

Polyamine derivatives as inhibitors of trypanothione reductase and assessment of their trypanocidal activities

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7 January 2021

Inhibiting effects of spermidine derivatives on Trypanosoma cruzi trypanothione reductase

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7 January 2021

"Subversive" substrates for the enzyme trypanothione disulfide reductase: alternative approach to chemotherapy of Chagas disease

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7 January 2021

Co-amplification of the gamma-glutamylcysteine synthetase gene gsh1 and of the ABC transporter gene pgpA in arsenite-resistant Leishmania tarentolae.

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7 January 2021

2.2 Mb of contiguous nucleotide sequence from chromosome III of C. elegans

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7 January 2021

Cellular glutathione peroxidase is the mediator of body selenium to protect against paraquat lethality in transgenic mice

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7 January 2021

Knockout of cellular glutathione peroxidase affects selenium-dependent parameters similarly in mice fed adequate and excessive dietary selenium.

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7 January 2021

Parasite sulphur amino acid metabolism

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7 January 2021

MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures

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7 January 2021

10.1016/S0891-5849(99)00172-0

Identifiers

DOI

1 reference

29 July 2017

1 reference