HSPs drive dichotomous T-cell immune responses via DNA methylome remodelling in antigen presenting cells. (Q33766735)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28561043%20AND%20SRC:MED&resulttype=core&format=json

21 March 2020

title

HSPs drive dichotomous T-cell immune responses via DNA methylome remodelling in antigen presenting cells (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28561043%20AND%20SRC:MED&resulttype=core&format=json

21 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28561043%20AND%20SRC:MED&resulttype=core&format=json

21 March 2020

author name string

Lauren B Kinner-Bibeau

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28561043%20AND%20SRC:MED&resulttype=core&format=json

21 March 2020

Michelle N Messmer

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28561043%20AND%20SRC:MED&resulttype=core&format=json

21 March 2020

Simon C Watkins

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28561043%20AND%20SRC:MED&resulttype=core&format=json

21 March 2020

Robert J Binder

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28561043%20AND%20SRC:MED&resulttype=core&format=json

21 March 2020

language of work or name

English

0 references

publication date

31 May 2017

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28561043%20AND%20SRC:MED&resulttype=core&format=json

21 March 2020

published in

Nature Communications

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28561043%20AND%20SRC:MED&resulttype=core&format=json

21 March 2020

volume

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28561043%20AND%20SRC:MED&resulttype=core&format=json

21 March 2020

page(s)

15648

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28561043%20AND%20SRC:MED&resulttype=core&format=json

Creative Commons Attribution 4.0 International

21 March 2020

start time

31 May 2017

1 reference

April 2022 Public Data File from Crossref

copyrighted

0 references

cites work

Bacterial infection remodels the DNA methylation landscape of human dendritic cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5460028

The multifaceted biology of plasmacytoid dendritic cells

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5460028

Initiation and termination of DNA replication during S phase in relation to cyclins D1, E and A, p21WAF1, Cdt1 and the p12 subunit of DNA polymerase δ revealed in individual cells by cytometry

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5460028

Leishmania donovani infection causes distinct epigenetic DNA methylation changes in host macrophages

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5460028

Gene body methylation can alter gene expression and is a therapeutic target in cancer.

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5460028

Establishment of tumor-associated immunity requires interaction of heat shock proteins with CD91.

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5460028

CpG sites associated with NRP1, NRXN2 and miR-29b-2 are hypomethylated in monocytes during ageing

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5460028

Heat-shock protein peptide complex-96 vaccination for recurrent glioblastoma: a phase II, single-arm trial

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5460028

Identification of the cellular sentinels for native immunogenic heat shock proteins in vivo.

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5460028

Role of NADPH oxidase NOX5-S, NF-κB, and DNMT1 in acid-induced p16 hypermethylation in Barrett's cells

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5460028

Stability and function of regulatory T cells is maintained by a neuropilin-1-semaphorin-4a axis.

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5460028

Induction of regulatory T cells by high-dose gp96 suppresses murine liver immune hyperactivation

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5460028

T cell receptor (TCR) and transforming growth factor β (TGF-β) signaling converge on DNA (cytosine-5)-methyltransferase to control forkhead box protein 3 (foxp3) locus methylation and inducible regulatory T cell differentiation

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5460028

The dendritic cell-regulatory T lymphocyte crosstalk contributes to tumor-induced tolerance

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5460028

CD91-dependent programming of T-helper cell responses following heat shock protein immunization

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5460028

Neuronal activity modifies the DNA methylation landscape in the adult brain

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5460028

Phosphorylation of RelA/p65 promotes DNMT-1 recruitment to chromatin and represses transcription of the tumor metastasis suppressor gene BRMS1

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5460028

Tabix: fast retrieval of sequence features from generic TAB-delimited files

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5460028

Extracellular heat shock proteins, cellular export vesicles, and the Stress Observation System: a form of communication during injury, infection, and cell damage. It is never known how far a controversial finding will go! Dedicated to Ferruccio Rito

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5460028

High efficiency CD91- and LOX-1-mediated re-presentation of gp96-chaperoned peptides by MHC II molecules

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5460028

Changes in the pattern of DNA methylation associate with twin discordance in systemic lupus erythematosus

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5460028

gp96, an endoplasmic reticulum master chaperone for integrins and Toll-like receptors, selectively regulates early T and B lymphopoiesis

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5460028

Treg suppress CTL responses upon immunization with HSP gp96.

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5460028

Regulatory T cells: how do they suppress immune responses?

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5460028

Control of regulatory T cell lineage commitment and maintenance

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5460028

Efficiency analysis of competing tests for finding differentially expressed genes in lung adenocarcinoma.

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5460028

Human plasmacytoid dendritic cells interact with gp96 via CD91 and regulate inflammatory responses

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5460028

Model-based analysis of ChIP-Seq (MACS)

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5460028

An adjuvant autologous therapeutic vaccine (HSPPC-96; vitespen) versus observation alone for patients at high risk of recurrence after nephrectomy for renal cell carcinoma: a multicentre, open-label, randomised phase III trial

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5460028

Neuropilin-1 expression on regulatory T cells enhances their interactions with dendritic cells during antigen recognition

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5460028

Specific immunogenicity of heat shock protein gp96 derives from chaperoned antigenic peptides and not from contaminating proteins

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5460028

GeneTrail--advanced gene set enrichment analysis

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5460028

Characterization of Siglec-H as a novel endocytic receptor expressed on murine plasmacytoid dendritic cell precursors

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5460028

Neuron restrictive silencer factor NRSF/REST is a transcriptional repressor of neuropilin-1 and diminishes the ability of semaphorin 3A to inhibit keratinocyte migration

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5460028

caGEDA: a web application for the integrated analysis of global gene expression patterns in cancer.

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5460028

Essential role of CD91 in re-presentation of gp96-chaperoned peptides

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5460028

Human tumor-derived heat shock protein 96 mediates in vitro activation and in vivo expansion of melanoma- and colon carcinoma-specific T cells.

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5460028

MethPrimer: designing primers for methylation PCRs

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5460028

Dnmt3a and Dnmt1 functionally cooperate during de novo methylation of DNA.

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5460028

Cooperativity between DNA methyltransferases in the maintenance methylation of repetitive elements

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5460028

Immunization of cancer patients with autologous cancer-derived heat shock protein gp96 preparations: a pilot study

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5460028

The dual nature of specific immunological activity of tumor-derived gp96 preparations

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5460028

CTLA-4 engagement inhibits IL-2 accumulation and cell cycle progression upon activation of resting T cells

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5460028

Tumor rejection antigens of chemically induced sarcomas of inbred mice

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5460028

Activation of mammalian DNA methyltransferase by cleavage of a Zn binding regulatory domain

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5460028

CD91 is a common receptor for heat shock proteins gp96, hsp90, hsp70, and calreticulin

22 June 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS15648

Bacterial heat shock proteins promote CD91-dependent class I MHC cross-presentation of chaperoned peptide to CD8+ T cells by cytosolic mechanisms in dendritic cells versus vacuolar mechanisms in macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS15648

Necrotic but not apoptotic cell death releases heat shock proteins, which deliver a partial maturation signal to dendritic cells and activate the NF-kappa B pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS15648

Phase III comparison of vitespen, an autologous tumor-derived heat shock protein gp96 peptide complex vaccine, with physician's choice of treatment for stage IV melanoma: the C-100-21 Study Group.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS15648

Immune modulation with high-dose heat-shock protein gp96: therapy of murine autoimmune diabetes and encephalomyelitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS15648

In vivo treatment of mice with heat shock protein, gp 96, improves survival of skin grafts with minor and major antigenic disparity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS15648

Differential patterns of methylation of the IFN-gamma promoter at CpG and non-CpG sites underlie differences in IFN-gamma gene expression between human neonatal and adult CD45RO- T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS15648

Selective, stable demethylation of the interleukin-2 gene enhances transcription by an active process

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS15648

Il2 transcription unleashed by active DNA demethylation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS15648

Rapid demethylation of the IFN-gamma gene occurs in memory but not naive CD8 T cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS15648

Direct observation of ligand recognition by T cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS15648

Specificity of Dnmt1 for methylation of hemimethylated CpG sites resides in its catalytic domain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS15648

GP96 is a GARP chaperone and controls regulatory T cell functions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS15648

Methylome repatterning in a mouse model of Maternal PKU Syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS15648

Determinants of efficacy of immunotherapy with tumor-derived heat shock protein gp96

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5460028

A neuronal receptor, neuropilin-1, is essential for the initiation of the primary immune response

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5460028

Bone Marrow Stromal Cell Antigen 2 Is a Specific Marker of Type I IFN-Producing Cells in the Naive Mouse, but a Promiscuous Cell Surface Antigen following IFN Stimulation

30 October 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS15648

Isolation and identification of renal cell carcinoma-derived peptides associated with GP96

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS15648

7 January 2021

CD91: a receptor for heat shock protein gp96

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS15648

7 January 2021

Immunotherapy of Tumors with Autologous Tumor-Derived Heat Shock Protein Preparations

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS15648

7 January 2021

TLR4 hyperresponsiveness via cell surface expression of heat shock protein gp96 potentiates suppressive function of regulatory T cells

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS15648

7 January 2021

Identifiers

DOI

10.1038/NCOMMS15648

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28561043%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

21 March 2020

ADS bibcode

2017NatCo...815648K

0 references

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28561043%20AND%20SRC:MED&resulttype=core&format=json

21 March 2020

PubMed publication ID

28561043

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28561043%20AND%20SRC:MED&resulttype=core&format=json