DNA polymerases as potential therapeutic targets for cancers deficient in the DNA mismatch repair proteins MSH2 or MLH1 (Q33754229)

29 July 2017

title

DNA polymerases as potential therapeutic targets for cancers deficient in the DNA mismatch repair proteins MSH2 or MLH1 (English)

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29 July 2017

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Christopher J Lord

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Yusaku Nakabeppu

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Darren J Burgess

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Alan Ashworth

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29 July 2017

Nuala McCabe

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29 July 2017

Sarah A Martin

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29 July 2017

Michelle Mullarkey

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29 July 2017

Robert Cummins

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29 July 2017

Sugako Oka

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29 July 2017

Elaine Kay

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29 July 2017

publication date

1 March 2010

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29 July 2017

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29 July 2017

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29 July 2017

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29 July 2017

page(s)

235-248

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Methotrexate induces oxidative DNA damage and is selectively lethal to tumour cells with defects in the DNA mismatch repair gene MSH2

29 July 2017

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Human MLH1 protein participates in genomic damage checkpoint signaling in response to DNA interstrand crosslinks, while MSH2 functions in DNA repair

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Entecavir for treatment of hepatitis B virus displays no in vitro mitochondrial toxicity or DNA polymerase gamma inhibition

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21 June 2018

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21 June 2018

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Repair of DNA interstrand cross-links: interactions between homology-dependent and homology-independent pathways

21 June 2018

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8-oxoguanine incorporation into DNA repeats in vitro and mismatch recognition by MutSalpha

21 June 2018

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The concept of synthetic lethality in the context of anticancer therapy

21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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Role of hMLH1 promoter hypermethylation in drug resistance to 5-fluorouracil in colorectal cancer cell lines.

21 June 2018

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Mutagenic potentials of damaged nucleic acids produced by reactive oxygen/nitrogen species: approaches using synthetic oligonucleotides and nucleotides: survey and summary

21 June 2018

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Analysis of conditional mutations in the Saccharomyces cerevisiae MLH1 gene in mismatch repair and in meiotic crossing over.

21 June 2018

1 reference

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DNA mismatch repair defects: role in colorectal carcinogenesis

21 June 2018

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hMutSbeta is required for the recognition and uncoupling of psoralen interstrand cross-links in vitro

21 June 2018

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21 June 2018

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21 June 2018

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DNA polymerase beta inhibitors from Sandoricum koetjape

21 June 2018

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21 June 2018

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Integrating Genetic Approaches into the Discovery of Anticancer Drugs

21 June 2018

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Correction of hypermutability, N-methyl-N'-nitro-N-nitrosoguanidine resistance, and defective DNA mismatch repair by introducing chromosome 2 into human tumor cells with mutations in MSH2 and MSH6

21 June 2018

1 reference

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Hypermutability of homonucleotide runs in mismatch repair and DNA polymerase proofreading yeast mutants.

21 June 2018

1 reference

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Computational method to predict mitochondrially imported proteins and their targeting sequences

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2845806

Microsatellite instability, mismatch repair deficiency, and genetic defects in human cancer cell lines.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2845806

Pathway correcting DNA replication errors in Saccharomyces cerevisiae

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2845806

Human chromosome 3 corrects mismatch repair deficiency and microsatellite instability and reduces N-methyl-N'-nitro-N-nitrosoguanidine tolerance in colon tumor cells with homozygous hMLH1 mutation

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2845806

Strand breaks arising from the repair of the 5-bromodeoxyuridine-substituted template and methyl methanesulphonate-induced lesions can explain the formation of sister chromatid exchanges.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2845806

Genetic testing for hereditary nonpolyposis colorectal cancer (HNPCC).

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2845806

Phenotype comparison of MLH1 and MSH2 mutation carriers in a cohort of 1,914 individuals undergoing clinical genetic testing in the United States

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2845806

CHIP-mediated degradation and DNA damage-dependent stabilization regulate base excision repair proteins.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2845806

DNA polymerase gamma inhibition by vitamin K3 induces mitochondria-mediated cytotoxicity in human cancer cells.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2845806

Identification of small molecule synthetic inhibitors of DNA polymerase beta by NMR chemical shift mapping.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2845806

Involvement of DNA polymerase beta in protection against the cytotoxicity of oxidative DNA damage.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2845806

The mammalian mismatch repair pathway removes DNA 8-oxodGMP incorporated from the oxidized dNTP pool

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2845806

Mutator effects of overproducing DNA polymerase eta (Rad30) and its catalytically inactive variant in yeast

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2845806

N-(2-chloroethyl)-N'-cyclohexyl-N-nitrosourea sensitivity in mismatch repair-defective human cells.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2845806

Minimizing the risk of reporting false positives in large-scale RNAi screens

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2845806

The cyanogenic glucoside, prunasin (D-mandelonitrile-beta-D-glucoside), is a novel inhibitor of DNA polymerase beta

30 October 2018

1 reference

12 December 2020

Modulation of cellular response to cisplatin by a novel inhibitor of DNA polymerase beta

1 reference

12 December 2020

Distinction of hereditary nonpolyposis colorectal cancer and sporadic microsatellite-unstable colorectal cancer through quantification of MLH1 methylation by real-time PCR

1 reference

12 December 2020

A plant phytotoxin, solanapyrone A, is an inhibitor of DNA polymerase beta and lambda

1 reference

12 December 2020

Cardiac mitochondrial DNA polymerase-gamma is inhibited competitively and noncompetitively by phosphorylated zidovudine

1 reference

12 December 2020

10.1016/J.CCR.2009.12.046

Identifiers

DOI

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29 July 2017

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29 July 2017

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