FXR activation reverses insulin resistance and lipid abnormalities and protects against liver steatosis in Zucker (fa/fa) obese rats (Q33741191)

29 July 2017

title

FXR activation reverses insulin resistance and lipid abnormalities and protects against liver steatosis in Zucker (fa/fa) obese rats (English)

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29 July 2017

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1 reference

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Sabrina Cipriani

1 reference

29 July 2017

Andrea Mencarelli

1 reference

29 July 2017

Giuseppe Palladino

series ordinal

1 reference

29 July 2017

Stefano Fiorucci

series ordinal

1 reference

29 July 2017

publication date

25 September 2009

1 reference

Journal of Lipid Research

29 July 2017

published in

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29 July 2017

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29 July 2017

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29 July 2017

page(s)

771-784

1 reference

Targetting farnesoid-X-receptor: from medicinal chemistry to disease treatment

29 July 2017

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Farnesoid X receptor induces GLUT4 expression through FXR response element in the GLUT4 promoter

14 July 2018

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14 July 2018

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The farnesoid X receptor promotes adipocyte differentiation and regulates adipose cell function in vivo

14 July 2018

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14 July 2018

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The farnesoid X receptor modulates adiposity and peripheral insulin sensitivity in mice

14 July 2018

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Activation of the nuclear receptor FXR improves hyperglycemia and hyperlipidemia in diabetic mice

14 July 2018

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Retinoid x receptor heterodimers in the metabolic syndrome

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Regulation of pyruvate dehydrogenase kinase expression by the farnesoid X receptor

14 July 2018

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14 July 2018

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Bile acids lower triglyceride levels via a pathway involving FXR, SHP, and SREBP-1c

14 July 2018

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Peroxisome proliferator-activated receptor-gamma coactivator 1alpha (PGC-1alpha) regulates triglyceride metabolism by activation of the nuclear receptor FXR

14 July 2018

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Bile acid-activated nuclear receptor FXR suppresses apolipoprotein A-I transcription via a negative FXR response element

14 July 2018

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Cellular mechanisms of insulin resistance

14 July 2018

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14 July 2018

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A molecular basis for insulin resistance. Elevated serine/threonine phosphorylation of IRS-1 and IRS-2 inhibits their binding to the juxtamembrane region of the insulin receptor and impairs their ability to undergo insulin-induced tyrosine phosphory

14 July 2018

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14 July 2018

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The farnesoid X receptor (FXR) as a new target in non-alcoholic steatohepatitis

14 July 2018

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The farnesoid X receptor modulates hepatic carbohydrate metabolism during the fasting-refeeding transition.

21 January 2018

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Development of insulin resistance and hyperphagia in Zucker fatty rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M001602

The nuclear receptor SHP mediates inhibition of hepatic stellate cells by FXR and protects against liver fibrosis

21 January 2018

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Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscle

21 January 2018

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Randomized, placebo-controlled trial of pioglitazone in nondiabetic subjects with nonalcoholic steatohepatitis

21 January 2018

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Protective effects of 6-ethyl chenodeoxycholic acid, a farnesoid X receptor ligand, in estrogen-induced cholestasis

21 January 2018

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Insulin resistance: a phosphorylation-based uncoupling of insulin signaling

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19783811

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Tumor necrosis factor alpha-induced phosphorylation of insulin receptor substrate-1 (IRS-1). Possible mechanism for suppression of insulin-stimulated tyrosine phosphorylation of IRS-1

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19783811

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1194/JLR.M001602

1 reference

29 July 2017

1 reference

29 July 2017

1 reference