Efficacy in drug receptor theory: outdated concept or under-valued tool? (Q33739391)

29 July 2017

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title

Efficacy in drug receptor theory: outdated concept or under-valued tool? (English)

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29 July 2017

Kenakin T

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29 July 2017

publication date

1 October 1999

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Trends in Pharmacological Sciences

29 July 2017

published in

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29 July 2017

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29 July 2017

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29 July 2017

page(s)

400-405

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The elusive nature of intrinsic efficacy

29 July 2017

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A Selective Inverse Agonist for Central Cannabinoid Receptor Inhibits Mitogen-activated Protein Kinase Activation Stimulated by Insulin or Insulin-like Growth Factor 1

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The relative contribution of affinity and efficacy to agonist activity: organ selectivity of noradrenaline and oxymetazoline with reference to the classification of drug receptors

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Pharmacological proteus?

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Protean agonists. Keys to receptor active states?

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Differential signal transduction by five splice variants of the PACAP receptor

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Effector pathway-dependent relative efficacy at serotonin type 2A and 2C receptors: evidence for agonist-directed trafficking of receptor stimulus

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Contribution of serine residues to constitutive and agonist-induced signaling via the D2S dopamine receptor: evidence for multiple, agonist-specific active conformations

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Selection of distinct conformational states of the 5-HT3 receptor by full and partial agonists

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Sequestration of the delta opioid receptor. Role of the C terminus in agonist-mediated internalization

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μ Opioid Receptor Phosphorylation, Desensitization, and Ligand Efficacy

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Cell Cycle-dependent Coupling of the Calcitonin Receptor to Different G Proteins

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Amino acids 356-372 constitute a Gi-activator sequence of the alpha 2-adrenergic receptor and have a Phe substitute in the G protein-activator sequence motif

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Signal transduction by calcitonin Multiple ligands, receptors, and signaling pathways

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RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor

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Factors determining specificity of signal transduction by G-protein-coupled receptors. Regulation of signal transfer from receptor to G-protein.

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7 January 2021

10.1016/S0165-6147(99)01361-9

Identifiers

DOI

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release_qbpr4mpzezhe5iizujee5n3rtq

29 July 2017

Fatcat ID

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Fatcat

https://api.fatcat.wiki/v0/release/qbpr4mpzezhe5iizujee5n3rtq

24 November 2022

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