Presenilins: structural aspects and posttranslational events. (Q33737450)

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English	Presenilins: structural aspects and posttranslational events.	scientific article

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Europe PubMed Central

PubMed publication ID

10495106

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10495106%20AND%20SRC:MED&resulttype=core&format=json

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31 October 2019

review article

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Europe PubMed Central

title

Presenilins: structural aspects and posttranslational events (English)

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Europe PubMed Central

PubMed publication ID

10495106

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10495106%20AND%20SRC:MED&resulttype=core&format=json

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31 October 2019

author

Frédéric Checler

series ordinal

1

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Europe PubMed Central

PubMed publication ID

10495106

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10495106%20AND%20SRC:MED&resulttype=core&format=json

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31 October 2019

author name string

Checler F

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1

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Europe PubMed Central

PubMed publication ID

10495106

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29 July 2017

publication date

1 June 1999

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Europe PubMed Central

PubMed publication ID

10495106

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10495106%20AND%20SRC:MED&resulttype=core&format=json

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31 October 2019

published in

Molecular Neurobiology

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Europe PubMed Central

PubMed publication ID

10495106

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10495106%20AND%20SRC:MED&resulttype=core&format=json

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31 October 2019

volume

19

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Europe PubMed Central

PubMed publication ID

10495106

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10495106%20AND%20SRC:MED&resulttype=core&format=json

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31 October 2019

issue

3

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Europe PubMed Central

PubMed publication ID

10495106

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10495106%20AND%20SRC:MED&resulttype=core&format=json

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31 October 2019

page(s)

255-265

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Europe PubMed Central

PubMed publication ID

10495106

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10495106%20AND%20SRC:MED&resulttype=core&format=json

retrieved

31 October 2019

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On the spurious endoproteolytic processing of the presenilin proteins in cultured cells and tissues

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The presenilin 1 protein is a component of a high molecular weight intracellular complex that contains beta-catenin

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Cellular expression and proteolytic processing of presenilin proteins is developmentally regulated during neuronal differentiation

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12 December 2020

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Different effects of Alzheimer-associated mutations of presenilin 1 on its processing

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12 December 2020

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Protein topology of presenilin 1

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12 December 2020

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Phosphorylation, subcellular localization, and membrane orientation of the Alzheimer's disease-associated presenilins.

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12 December 2020

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Alzheimer-associated presenilins 1 and 2: neuronal expression in brain and localization to intracellular membranes in mammalian cells.

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Identification and neuron specific expression of the S182/presenilin I protein in human and rodent brains

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12 December 2020

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Cell surface expression of the Alzheimer disease-related presenilin proteins

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12 December 2020

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Transcriptional Regulation of the Mouse Presenilin-1 Gene

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immunohistochemical analysis of presenilin-1 expression in the mouse brain

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/10495106

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of caspases that cleave presenilin-1 and presenilin-2. Five presenilin-1 (PS1) mutations do not alter the sensitivity of PS1 to caspases

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https://pubmed.ncbi.nlm.nih.gov/10495106

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12 December 2020

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A mutation in Alzheimer's disease destroying a splice acceptor site in the presenilin-1 gene.

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12 December 2020

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Amyloid beta protein gene: cDNA, mRNA distribution, and genetic linkage near the Alzheimer locus

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12 December 2020

based on heuristic

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Alternative Cleavage of Alzheimer-Associated Presenilins During Apoptosis by a Caspase-3 Family Protease

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/10495106

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Destabilization of beta-catenin by mutations in presenilin-1 potentiates neuronal apoptosis

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/10495106

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/10495106

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hyperaccumulation of FAD-linked presenilin 1 variants in vivo

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/10495106

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Presenilin mutations associated with Alzheimer disease cause defective intracellular trafficking of beta-catenin, a component of the presenilin protein complex

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/10495106

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genomic structure and expression of STM2, the chromosome 1 familial Alzheimer disease gene

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/10495106

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immunohistochemical analysis of presenilin 2 expression in the mouse brain: distribution pattern and co-localization with presenilin 1 protein

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/10495106

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A novel presenilin 1 mutation resulting in familial Alzheimer's disease with an onset age of 29 years

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/10495106

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Proteolytic processing of the Alzheimer disease-associated presenilin-1 generates an in vivo substrate for protein kinase C.

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/10495106

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphorylation of presenilin-2 regulates its cleavage by caspases and retards progression of apoptosis

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/10495106

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The presenilins and Alzheimer's disease

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/10495106

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Distinct Processing of Endogenous and Overexpressed Recombinant Presenilin 1

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/10495106

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuronal Expression and Intracellular Localization of Presenilins in Normal and Alzheimer Disease Brains

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/10495106

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Assessment of normal and mutant human presenilin function in Caenorhabditis elegans

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/10495106

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Presenilin 1 is actively degraded by the 26S proteasome

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/10495106

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Endoproteolytic Processing and Stabilization of Wild-type and Mutant Presenilin

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/10495106

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Facilitation of lin-12-mediated signalling by sel-12, a Caenorhabditis elegans S182 Alzheimer's disease gene

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/10495106

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Presenilins: multifunctional proteins involved in Alzheimer's disease pathology

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/10495106

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Presenilins, the endoplasmic reticulum, and neuronal apoptosis in Alzheimer's disease.

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/10495106

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alzheimer's disease associated presenilin-1 holoprotein and its 18-20 kDa C-terminal fragment are death substrates for proteases of the caspase family

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/10495106

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/10495106

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The structure of the presenilin 1 (S182) gene and identification of six novel mutations in early onset AD families

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/10495106

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alzheimer's disease-linked mutation of presenilin 2 (N141I-PS2) drastically lowers APPalpha secretion: control by the proteasome.

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/10495106

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Presenilins interact with armadillo proteins including neural-specific plakophilin-related protein and beta-catenin

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/10495106

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence for a physical interaction between presenilin and Notch

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/10495106

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A familial Alzheimer's disease locus on chromosome 1.

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/10495106

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Presenilins Are Processed by Caspase-type Proteases

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/10495106

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Presenilins: genes for life and death

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/10495106

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

C-terminal maturation fragments of presenilin 1 and 2 control secretion of APP alpha and A beta by human cells and are degraded by proteasome

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/10495106

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/10495106

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of brain G-protein go by Alzheimer's disease gene presenilin-1.

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/10495106

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alzheimer Presenilins in the Nuclear Membrane, Interphase Kinetochores, and Centrosomes Suggest a Role in Chromosome Segregation

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/10495106

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immunoreactivity of presenilin-1 in human, rat and mouse brain

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/10495106

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/10495106

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Presenilins interact with Rab11, a small GTPase involved in the regulation of vesicular transport

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/10495106

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular genetics of Alzheimer disease amyloid

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/10495106

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization and chromosomal localization of a cDNA encoding brain amyloid of Alzheimer's disease

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/10495106

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A novel Polish presenilin-1 mutation (P117L) is associated with familial Alzheimer's disease and leads to death as early as the age of 28 years.

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/10495106

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of PS1 deficiency on membrane protein trafficking in neurons

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/10495106

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/10495106

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Presenilin is required for activity and nuclear access of Notch in Drosophila

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/10495106

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The gene defects responsible for familial Alzheimer's disease

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/10495106

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Presenilin 1 associates with glycogen synthase kinase-3beta and its substrate tau

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/10495106

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Abrogation of the presenilin 1/beta-catenin interaction and preservation of the heterodimeric presenilin 1 complex following caspase activation

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/10495106

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression and analysis of presenilin 1 in a human neuronal system: localization in cell bodies and dendrites

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/10495106

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Calsenilin: a calcium-binding protein that interacts with the presenilins and regulates the levels of a presenilin fragment

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/10495106

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuronal localization of presenilin-1 and association with amyloid plaques and neurofibrillary tangles in Alzheimer's disease.

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/10495106

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Presenilin-1 is processed into two major cleavage products in neuronal cell lines

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/10495106

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Processing of presenilin 1 in brains of patients with Alzheimer's disease and controls

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/10495106

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alzheimer's disease associated with mutations in presenilin 2 is rare and variably penetrant.

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/10495106

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The proteolytic fragments of the Alzheimer's disease-associated presenilin-1 form heterodimers and occur as a 100-150-kDa molecular mass complex

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/10495106

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Proteolytic processing of presenilin-1 (PS-1) is not associated with Alzheimer's disease with or without PS-1 mutations

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/10495106

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of human presenilin 1 using N-terminal specific monoclonal antibodies: Evidence that Alzheimer mutations affect proteolytic processing

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/10495106

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structure and alternative splicing of the presenilin-2 gene

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/10495106

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/10495106

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Membrane topology of the C. elegans SEL-12 presenilin

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/10495106

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Endoproteolytic cleavage and proteasomal degradation of presenilin 2 in transfected cells

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/10495106

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neurogenic phenotypes and altered Notch processing in Drosophila Presenilin mutants.

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/10495106

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amyloid, the presenilins and Alzheimer's disease

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/10495106

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regional distribution of presenilin-1 messenger RNA in the embryonic rat brain: comparison with beta-amyloid precursor protein messenger RNA localization

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/10495106

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genetic and molecular advances in Alzheimer's disease

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/10495106

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Alzheimer's disease-associated presenilins are differentially phosphorylated proteins located predominantly within the endoplasmic reticulum

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/10495106

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence for phosphorylation and oligomeric assembly of presenilin 1.

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/10495106

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Determination of a Cleavage Site of Presenilin 2 Protein in Stably Transfected SH-SY5Y Human Neuroblastoma Cell Lines

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/10495106

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alzheimer's disease-associated presenilin 1 in neuronal cells: evidence for localization to the endoplasmic reticulum-Golgi intermediate compartment

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/10495106

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/10495106

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genetic dissection of Alzheimer disease, a heterogeneous disorder

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/10495106

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dual roles of proteasome in the metabolism of presenilin 1.

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/10495106

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Localization of Alzheimer-associated presenilin 1 in transfected COS-7 cells.

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/10495106

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Candidate gene for the chromosome 1 familial Alzheimer's disease locus

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/10495106

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

DOI

10.1007/BF02821716

1 reference

stated in

Europe PubMed Central

PubMed publication ID

10495106

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10495106%20AND%20SRC:MED&resulttype=core&format=json

retrieved

31 October 2019

Dimensions Publication ID

1050594427

0 references

PubMed publication ID

10495106

1 reference

stated in

Europe PubMed Central

PubMed publication ID

10495106

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10495106%20AND%20SRC:MED&resulttype=core&format=json

retrieved

31 October 2019

 

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