Nonallele-specific silencing of mutant and wild-type huntingtin demonstrates therapeutic efficacy in Huntington's disease mice. (Q33713689)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19240687%20AND%20SRC:MED&resulttype=core&format=json

22 January 2020

title

Nonallele-specific silencing of mutant and wild-type huntingtin demonstrates therapeutic efficacy in Huntington's disease mice (English)

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22 January 2020

0 references

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22 January 2020

Jodi L McBride

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22 January 2020

Inês Martins

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22 January 2020

Shihao Shen

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22 January 2020

Yi Xing

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22 January 2020

Barrie J Carter

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22 January 2020

Beverly L Davidson

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22 January 2020

publication date

24 February 2009

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22 January 2020

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22 January 2020

volume

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22 January 2020

issue

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22 January 2020

page(s)

1053-1063

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Artificial microRNAs as siRNA shuttles: improved safety as compared to shRNAs in vitro and in vivo

22 January 2020

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Huntingtin modulates transcription, occupies gene promoters in vivo, and binds directly to DNA in a polyglutamine-dependent manner

21 June 2018

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21 June 2018

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Sertraline slows disease progression and increases neurogenesis in N171-82Q mouse model of Huntington's disease

21 June 2018

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Tiagabine is neuroprotective in the N171-82Q and R6/2 mouse models of Huntington's disease

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21 June 2018

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Mutant huntingtin's effects on striatal gene expression in mice recapitulate changes observed in human Huntington's disease brain and do not differ with mutant huntingtin length or wild-type huntingtin dosage

21 June 2018

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Identification of the REST regulon reveals extensive transposable element-mediated binding site duplication

21 June 2018

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Viral delivery of glial cell line-derived neurotrophic factor improves behavior and protects striatal neurons in a mouse model of Huntington's disease

21 June 2018

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21 June 2018

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Regional and cellular gene expression changes in human Huntington's disease brain

21 June 2018

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In vitro analysis of huntingtin-mediated transcriptional repression reveals multiple transcription factor targets

21 June 2018

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siRNA-mediated inhibition of endogenous Huntington disease gene expression induces an aberrant configuration of the ER network in vitro

21 June 2018

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Clinico-pathological rescue of a model mouse of Huntington's disease by siRNA.

21 June 2018

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Intrastriatal rAAV-mediated delivery of anti-huntingtin shRNAs induces partial reversal of disease progression in R6/1 Huntington's disease transgenic mice

21 June 2018

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RNA interference improves motor and neuropathological abnormalities in a Huntington's disease mouse model

21 June 2018

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Anti-inflammatory treatment with acetylsalicylate or rofecoxib is not neuroprotective in Huntington's disease transgenic mice

21 June 2018

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21 June 2018

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Huntingtin controls neurotrophic support and survival of neurons by enhancing BDNF vesicular transport along microtubules

21 June 2018

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21 June 2018

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Cellular toxicity of polyglutamine expansion proteins: mechanism of transcription factor deactivation

21 June 2018

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Huntingtin interacts with REST/NRSF to modulate the transcription of NRSE-controlled neuronal genes

21 June 2018

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21 June 2018

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Wild-type huntingtin protects from apoptosis upstream of caspase-3.

21 June 2018

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Huntingtin is required for neurogenesis and is not impaired by the Huntington's disease CAG expansion

21 June 2018

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Targeted disruption of the Huntington's disease gene results in embryonic lethality and behavioral and morphological changes in heterozygotes

21 June 2018

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Inactivation of the mouse Huntington's disease gene homolog Hdh

21 June 2018

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Increased apoptosis and early embryonic lethality in mice nullizygous for the Huntington's disease gene homologue

21 June 2018

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21 June 2018

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Identification and allele-specific silencing of the mutant huntingtin allele in Huntington's disease patient-derived fibroblasts.

21 June 2018

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Myelin breakdown and iron changes in Huntington's disease: pathogenesis and treatment implications

30 October 2018

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Wild-type huntingtin participates in protein trafficking between the Golgi and the extracellular space

30 October 2018

1 reference

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Sp1 is up-regulated in cellular and transgenic models of Huntington disease, and its reduction is neuroprotective

30 October 2018

1 reference

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Silencing primary dystonia: lentiviral-mediated RNA interference therapy for DYT1 dystonia.

30 October 2018

1 reference

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Stochastic models inspired by hybridization theory for short oligonucleotide arrays.

30 October 2018

1 reference

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Minocycline in phenotypic models of Huntington's disease

30 October 2018

1 reference

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Neuroprotective effects of phenylbutyrate in the N171-82Q transgenic mouse model of Huntington's disease

30 October 2018

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Histone Deacetylase Inhibition by Sodium Butyrate Chemotherapy Ameliorates the Neurodegenerative Phenotype in Huntington's Disease Mice

30 October 2018

1 reference

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Early transcriptional profiles in huntingtin-inducible striatal cells by microarray analyses

30 October 2018

1 reference

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Regional and progressive thinning of the cortical ribbon in Huntington's disease

30 October 2018

1 reference

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Therapeutic effects of coenzyme Q10 and remacemide in transgenic mouse models of Huntington's disease.

30 October 2018

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The HD mutation causes progressive lethal neurological disease in mice expressing reduced levels of huntingtin

30 October 2018

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Creatine increase survival and delays motor symptoms in a transgenic animal model of Huntington's disease

30 October 2018

1 reference

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Intranuclear inclusions and neuritic aggregates in transgenic mice expressing a mutant N-terminal fragment of huntingtin

30 October 2018

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Huntingtin acts in the nucleus to induce apoptosis but death does not correlate with the formation of intranuclear inclusions.

30 October 2018

1 reference

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Mutant huntingtin inhibits clathrin-independent endocytosis and causes accumulation of cholesterol in vitro and in vivo

30 October 2018

1 reference

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30 October 2018

Identifiers

DOI

10.1038/MT.2009.17

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19240687%20AND%20SRC:MED&resulttype=core&format=json

22 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19240687%20AND%20SRC:MED&resulttype=core&format=json

22 January 2020

PubMed publication ID

19240687

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19240687%20AND%20SRC:MED&resulttype=core&format=json