Small molecule inhibitors of tumor-promoted angiogenesis, including protein tyrosine kinase inhibitors (Q33716104)

28 July 2017

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title

Small molecule inhibitors of tumor-promoted angiogenesis, including protein tyrosine kinase inhibitors (English)

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28 July 2017

Hamby JM

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28 July 2017

Showalter HD

series ordinal

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28 July 2017

publication date

1 May 1999

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Pharmacology & Therapeutics

28 July 2017

published in

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28 July 2017

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28 July 2017

issue

2-3

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28 July 2017

page(s)

169-193

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An anti-human VEGF monoclonal antibody, MV833, that exhibits potent anti-tumor activity in vivo

28 July 2017

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Neutralizing anti-vascular endothelial growth factor antibody completely inhibits angiogenesis and growth of human prostate carcinoma micro tumors in vivo

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Exploiting tumour hypoxia and overcoming mutant p53 with tirapazamine

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Molecular mechanisms of blood vessel formation

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TNP-470 (AGM-1470): mechanisms of action and early clinical development.

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A secreted FGF-binding protein can serve as the angiogenic switch in human cancer.

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Thalidomide is an inhibitor of angiogenesis

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Control of angiogenesis in fibroblasts by p53 regulation of thrombospondin-1

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Comparison of VEGF, VEGF-B, VEGF-C and Ang-1 mRNA regulation by serum, growth factors, oncoproteins and hypoxia

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7 January 2021

Tumor angiogenesis: therapeutic implications

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7 January 2021

Anti-angiogenesis: new concept for therapy of solid tumors

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7 January 2021

Isolation of a tumor factor responsible for angiogenesis

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7 January 2021

Angiogenesis Inhibition and Tumor Regression Caused by Heparin or a Heparin Fragment in the Presence of Cortisone

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7 January 2021

The endogenous oestrogen metabolite 2-methoxyoestradiol inhibits angiogenesis and suppresses tumour growth

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7 January 2021

An overview of clinical trials involving inhibitors of angiogenesis and their mechanism of action

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7 January 2021

Therapeutic efficacy of the angiogenesis inhibitor O- (Chloroacetyl- carbamoyl) fumagillol (TNP-470; AGM-1470) for human anaplastic thyroid carcinoma in nude mice

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7 January 2021

Structure−Activity Relationships for a Novel Series of Pyrido[2,3-d]pyrimidine Tyrosine Kinase Inhibitors

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7 January 2021

Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis

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7 January 2021

Transgenic mouse models of tumour angiogenesis: the angiogenic switch, its molecular controls, and prospects for preclinical therapeutic models

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7 January 2021

Effects of TNP-470, a potent angiogenesis inhibitor, on growth of hematopoietic progenitors

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7 January 2021

Interstitial pH and pO2 gradients in solid tumors in vivo: high-resolution measurements reveal a lack of correlation

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7 January 2021

Dormancy of micrometastases: Balanced proliferation and apoptosis in the presence of angiogenesis suppression

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7 January 2021

Suppressive effect of the angiogenesis inhibitor TNP-470 on the development of carcinogen-induced hepatic nodules in rats.

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7 January 2021

Synthetic analogues of fumagillin that inhibit angiogenesis and suppress tumour growth

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7 January 2021

Tranilast inhibits the proliferation, chemotaxis and tube formation of human microvascular endothelial cells in vitro and angiogenesis in vivo

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7 January 2021

An examination of the effects of hypoxia, acidosis, and glucose starvation on the expression of metastasis-associated genes in murine tumor cells

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7 January 2021

Inhibition of malignant angiogenesis

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7 January 2021

Effect of angiogenesis inhibitor TNP-470 on the progression of human gastric cancer xenotransplanted into nude mice

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7 January 2021

Combined analysis of p53 and vascular endothelial growth factor expression in colorectal carcinoma for determination of tumor vascularity and liver metastasis

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7 January 2021

Critical components of the female reproductive pathway are suppressed by the angiogenesis inhibitor AGM-1470

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7 January 2021

Inhibitory effects of tetrandrine on angiogenesis in adjuvant-induced chronic inflammation and tube formation of vascular endothelial cells

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7 January 2021

Phase I trial of micronized formulation carboxyamidotriazole in patients with refractory solid tumors: pharmacokinetics, clinical outcome, and comparison of formulations

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7 January 2021

Gene therapy strategies for tumor antiangiogenesis

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7 January 2021

Clinical research on antiangiogenic therapy

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7 January 2021

Potent anti-angiogenic action of AGM-1470: comparison to the fumagillin parent

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7 January 2021

Cytostatic inhibition of endothelial cell growth by the angiogenesis inhibitor TNP-470 (AGM-1470).

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7 January 2021

American Association for Cancer Research 1998: promises and prospects for the next century

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7 January 2021

Protein kinase inhibitors: the tyrosine-specific protein kinases

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7 January 2021

In vitro inhibition of endothelial cell growth by the antiangiogenic drug AGM-1470 (TNP-470) and the anti-endoglin antibody TEC-11.

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7 January 2021

The power of the front page of The New York Times

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7 January 2021

The endothelial receptor tyrosine kinase tie-1 is upregulated by hypoxia and vascular endothelial growth factor.

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7 January 2021

Results of single and repeat dose studies of the oral matrix metalloproteinase inhibitor marimastat in healthy male volunteers

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7 January 2021

Crystal structure of an angiogenesis inhibitor bound to the FGF receptor tyrosine kinase domain.

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7 January 2021

Tumor vascular endothelium: barrier or target in tumor directed drug delivery and immunotherapy

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7 January 2021

Tumor Vasculature Targeted Therapies

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7 January 2021

Antiangiogenic Agent (TNP-470) Inhibition of Ectopic Bone Formation Induced by Bone Morphogenetic Protein-2

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7 January 2021

Eriochrome Black T, structurally related to suramin, inhibits angiogenesis and tumor growth in vivo

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7 January 2021

Reduction in basic fibroblast growth factor mediated angiogenesis in vivo by linomide

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7 January 2021

Corticosteroids inhibit the expression of the vascular endothelial growth factor gene in human vascular smooth muscle cells

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7 January 2021

Angiogenesis: new aspects relating to its initiation and control

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7 January 2021

Inhibition of lymph node metastasis by an anti-angiogenic agent, TNP-470.

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7 January 2021

The proteasome is involved in angiogenesis

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7 January 2021

Impact of oncogenes in tumor angiogenesis: mutant K-ras up-regulation of vascular endothelial growth factor/vascular permeability factor is necessary, but not sufficient for tumorigenicity of human colorectal carcinoma cells

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7 January 2021

Angiostatin: A Circulating Endothelial Cell Inhibitor That Suppresses Angiogenesis and Tumor Growth

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7 January 2021

Angiostatin: A novel angiogenesis inhibitor that mediates the suppression of metastases by a lewis lung carcinoma

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7 January 2021

Angiostatin induces and sustains dormancy of human primary tumors in mice

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7 January 2021

Endostatin: an endogenous inhibitor of angiogenesis and tumor growth

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7 January 2021

Effects of linomide on advanced prostate-seminal vesicle cancers in Lobund-Wistar rats.

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7 January 2021

Basic fibroblast growth factor and the complexity of tumour angiogenesis

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7 January 2021

Matrix Metalloproteinase Inhibition as a Novel Anticancer Strategy: A Review with Special Focus on Batimastat and Marimastat

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7 January 2021

Expression of the angiogenic factors, basic fibroblast growth factor and vascular endothelial growth factor, in the ovary

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7 January 2021

Angiogenic growth factors

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7 January 2021

Hypoxia-induced angiogenesis and vascular endothelial growth factor secretion in human melanoma

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7 January 2021

Response of tumour cells to hypoxia: role of p53 and NFkB.

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7 January 2021

Rodent pharmacokinetic and anti-tumor efficacy studies with a series of synthetic inhibitors of matrix metalloproteinases

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7 January 2021

Role of the hypoxia sensing system, acidity and reproductive hormones in the variability of vascular endothelial growth factor induction in human breast carcinoma cell lines

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7 January 2021

Intracellular signaling by growth factors

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7 January 2021

Thrombospondin 1 expression in transformed endothelial cells restores a normal phenotype and suppresses their tumorigenesis

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7 January 2021

Heparin Affinity: Purification of a Tumor-Derived Capillary Endothelial Cell Growth Factor

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7 January 2021

Small molecule inhibitors of the platelet-derived growth factor receptor, the fibroblast growth factor receptor, and Src family tyrosine kinases

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7 January 2021

Inhibition of tumor growth and metastasis by angiogenesis inhibitor TNP-470 on breast cancer cell lines in vitro and in vivo

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7 January 2021

Tyrosine kinases in disease: overview of kinase inhibitors as therapeutic agents and current drugs in clinical trials

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7 January 2021

Synthesis and biological evaluations of 3-substituted indolin-2-ones: a novel class of tyrosine kinase inhibitors that exhibit selectivity toward particular receptor tyrosine kinases

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7 January 2021

A systems approach to cancer therapy. (Antioncogenics + standard cytotoxics-->mechanism(s) of interaction).

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7 January 2021

Development of a binding model to protein tyrosine kinases for substituted pyrido[2,3-d]pyrimidine inhibitors

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7 January 2021

Clinical trials of antiangiogenic agents

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7 January 2021

Endothelial cell-derived basic fibroblast growth factor: synthesis and deposition into subendothelial extracellular matrix

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7 January 2021

Inhibitors of angiogenesis in a clinical perspective

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7 January 2021

Sequential development of an angiogenic phenotype by human fibroblasts progressing to tumorigenicity

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7 January 2021

Antisense targeting of basic fibroblast growth factor and dibroblast growth factor receptor-1 in human melanomas blocks intratumoral angiogenesis and tumor growth

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7 January 2021

The angiogenesis inhibitor TNP-470 reduces the growth rate of human neuroblastoma in nude rats

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7 January 2021

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7 January 2021

Phase I trial of Marimastat, a novel matrix metalloproteinase inhibitor, administered orally to patients with advanced lung cancer

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7 January 2021

Expression of vascular endothelial growth factor (VEGF) during folliculogenesis and corpus luteum formation in the human ovary

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7 January 2021

Expression of angiogenesis-related genes and progression of human ovarian carcinomas in nude mice

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7 January 2021

Hypoxia induces DNA overreplication and enhances metastatic potential of murine tumor cells

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7 January 2021

2-Methoxyestradiol, an endogenous estrogen metabolite, induces apoptosis in endothelial cells and inhibits angiogenesis: possible role for stress-activated protein kinase signaling pathway and Fas expression.

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7 January 2021

Angiogenesis and Tumor Metastasis

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7 January 2021

Linomide blocks angiogenesis by breast carcinoma vascular endothelial growth factor transfectants

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7 January 2021

10.1016/S0163-7258(98)00053-9

Identifiers

DOI

1 reference

release_gbizbcjw3beqdcccw26qmcwfq4

28 July 2017

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/gbizbcjw3beqdcccw26qmcwfq4

24 November 2022

mapped directly with Wikidata item

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