Mechanisms of life span extension by rapamycin in the fruit fly Drosophila melanogaster (Q33665807)

28 July 2017

title

Mechanisms of life span extension by rapamycin in the fruit fly Drosophila melanogaster (English)

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28 July 2017

main subject

Drosophila melanogaster

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1 reference

1 reference

Linda Partridge

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Ivana Bjedov

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Fiona Kerr

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Janne M Toivonen

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Cathy Slack

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Jake Jacobson

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28 July 2017

Andrea Foley

series ordinal

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28 July 2017

language of work or name

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1 January 2010

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28 July 2017

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28 July 2017

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28 July 2017

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28 July 2017

page(s)

35-46

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Amino-acid imbalance explains extension of lifespan by dietary restriction in Drosophila

28 July 2017

cites work

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4E-BP extends lifespan upon dietary restriction by enhancing mitochondrial activity in Drosophila

21 June 2018

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21 June 2018

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Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

21 June 2018

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Quantification of food intake in Drosophila

21 June 2018

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Autophagy is required for extension of yeast chronological life span by rapamycin

21 June 2018

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Rictor/TORC2 regulates fat metabolism, feeding, growth, and life span in Caenorhabditis elegans

21 June 2018

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21 June 2018

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An Atg1/Atg13 complex with multiple roles in TOR-mediated autophagy regulation

21 June 2018

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Rag proteins regulate amino-acid-induced mTORC1 signalling.

21 June 2018

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Conditional inhibition of autophagy genes in adult Drosophila impairs immunity without compromising longevity

21 June 2018

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21 June 2018

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21 June 2018

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Aging and survival: the genetics of life span extension by dietary restriction.

21 June 2018

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A role for autophagy in the extension of lifespan by dietary restriction in C. elegans

21 June 2018

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Separating cause from effect: how does insulin/IGF signalling control lifespan in worms, flies and mice?

21 June 2018

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Optimization of dietary restriction protocols in Drosophila

21 June 2018

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MSN2 and MSN4 link calorie restriction and TOR to sirtuin-mediated lifespan extension in Saccharomyces cerevisiae.

21 June 2018

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Genetic links between diet and lifespan: shared mechanisms from yeast to humans

21 June 2018

1 reference

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Rapamycin: something old, something new, sometimes borrowed and now renewed

21 June 2018

1 reference

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21 June 2018

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No influence of Indy on lifespan in Drosophila after correction for genetic and cytoplasmic background effects

21 June 2018

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Recent developments in yeast aging

21 June 2018

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ATG1, an autophagy regulator, inhibits cell growth by negatively regulating S6 kinase

21 June 2018

1 reference

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AMP-Activated Protein Kinase in Metabolic Control and Insulin Signaling

21 June 2018

1 reference

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Lifespan extension by conditions that inhibit translation in Caenorhabditis elegans

21 June 2018

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21 June 2018

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Nutrient overload, insulin resistance, and ribosomal protein S6 kinase 1, S6K1.

21 June 2018

1 reference

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Functional genomics identifies TOR-regulated genes that control growth and division

21 June 2018

1 reference

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Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB

21 June 2018

1 reference

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TOR signaling in growth and metabolism

21 June 2018

1 reference

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Extension of chronological life span in yeast by decreased TOR pathway signaling

21 June 2018

1 reference

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4E-BP functions as a metabolic brake used under stress conditions but not during normal growth

21 June 2018

1 reference

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Starvation and oxidative stress resistance in Drosophila are mediated through the eIF4E-binding protein, d4E-BP.

21 June 2018

1 reference

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Calories do not explain extension of life span by dietary restriction in Drosophila

21 June 2018

1 reference

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Autophagosomes: biogenesis from scratch?

21 June 2018

1 reference

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Autophagy in metazoans: cell survival in the land of plenty

21 June 2018

1 reference

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Sex and death: what is the connection?

21 June 2018

1 reference

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Longer lifespan, altered metabolism, and stress resistance in Drosophila from ablation of cells making insulin-like ligands

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2824086

Role and regulation of starvation-induced autophagy in the Drosophila fat body

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2824086

Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2824086

Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2824086

Target of rapamycin (TOR): an integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2824086

Genetics: influence of TOR kinase on lifespan in C. elegans

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2824086

Autophagy genes are essential for dauer development and life-span extension in C. elegans

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2824086

Global and specific translational control by rapamycin in T cells uncovered by microarrays and proteomics

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2824086

Growth factor signaling in cell survival: implications for cancer treatment

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2824086

Extension of life-span by loss of CHICO, a Drosophila insulin receptor substrate protein

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2824086

The endosymbiont Wolbachia increases insulin/IGF-like signalling in Drosophila

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2824086

The pharmacology of mTOR inhibition

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2824086

Longevity pathways converge on autophagy genes to regulate life span in Caenorhabditis elegans.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2824086

Promoting basal levels of autophagy in the nervous system enhances longevity and oxidant resistance in adult Drosophila

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2824086

S6 kinase deletion suppresses muscle growth adaptations to nutrient availability by activating AMP kinase

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2824086

eIF4E function in somatic cells modulates ageing in Caenorhabditis elegans

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2824086

Activated FOXO-mediated insulin resistance is blocked by reduction of TOR activity.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2824086

Altering Drosophila S6 kinase activity is consistent with a role for S6 kinase in growth.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2824086

Drosophila S6 kinase: a regulator of cell size

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2824086

10.1016/J.CMET.2009.11.010

30 October 2018

Identifiers

DOI

1 reference

28 July 2017

1 reference

28 July 2017

1 reference