Identification of novel small molecule inhibitors of the XPA protein using in silico based screening (Q33641964)

28 July 2017

title

Identification of novel small molecule inhibitors of the XPA protein using in silico based screening (English)

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28 July 2017

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Tracy M Neher

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28 July 2017

Sarah C Shuck

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28 July 2017

Jing-Yuan Liu

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28 July 2017

Jian-Ting Zhang

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28 July 2017

John J Turchi

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28 July 2017

publication date

1 October 2010

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full work available at URL

28 July 2017

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2955790

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published in

ACS Chemical Biology

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28 July 2017

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28 July 2017

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28 July 2017

page(s)

953-965

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Targeted inhibition of Replication Protein A reveals cytotoxic activity, synergy with chemotherapeutic DNA-damaging agents, and insight into cellular function

28 July 2017

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21 June 2018

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Quantitative analyses of aggregation, autofluorescence, and reactivity artifacts in a screen for inhibitors of a thiol protease

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Direct inhibition of the NOTCH transcription factor complex

21 June 2018

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Stoichiometry and physical chemistry of promiscuous aggregate-based inhibitors

21 June 2018

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Rescoring Docking Hit Lists for Model Cavity Sites: Predictions and Experimental Testing

21 June 2018

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21 June 2018

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Transcription-coupled nucleotide excision repair in mammalian cells: molecular mechanisms and biological effects

21 June 2018

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Xeroderma pigmentosum complementation group A protein is driven to nucleotide excision repair sites by the electrostatic potential of distorted DNA.

21 June 2018

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A detergent-based assay for the detection of promiscuous inhibitors

21 June 2018

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Recognition of helical kinks by xeroderma pigmentosum group A protein triggers DNA excision repair

21 June 2018

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Cellular processing of platinum anticancer drugs

21 June 2018

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21 June 2018

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Development of a high-throughput screen for inhibitors of replication protein A and its role in nucleotide excision repair.

21 June 2018

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Cisplatin: mode of cytotoxic action and molecular basis of resistance

21 June 2018

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Chemical shift changes provide evidence for overlapping single-stranded DNA- and XPA-binding sites on the 70 kDa subunit of human replication protein A

21 June 2018

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21 June 2018

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Xeroderma pigmentosum complementation group A protein (XPA) modulates RPA-DNA interactions via enhanced complex stability and inhibition of strand separation activity

21 June 2018

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Strand-specific binding of RPA and XPA to damaged duplex DNA.

21 June 2018

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Comparison of four chemotherapy regimens for advanced non-small-cell lung cancer

21 June 2018

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Structure of the Ku heterodimer bound to DNA and its implications for double-strand break repair

21 June 2018

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DNA-XPA interactions: a (31)P NMR and molecular modeling study of dCCAATAACC association with the minimal DNA-binding domain (M98-F219) of the nucleotide excision repair protein XPA.

21 June 2018

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Overexpression and purification of human XPA using a baculovirus expression system

21 June 2018

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Interactions of human nucleotide excision repair protein XPA with DNA and RPA70 Delta C327: chemical shift mapping and 15N NMR relaxation studies

21 June 2018

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Human nucleotide excision repair protein XPA: extended X-ray absorption fine-structure evidence for a metal-binding domain

21 June 2018

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Solution structure of the DNA- and RPA-binding domain of the human repair factor XPA

21 June 2018

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Structural features of the minimal DNA binding domain (M98-F219) of human nucleotide excision repair protein XPA.

21 June 2018

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Human nucleotide excision repair protein XPA: 1H NMR and CD solution studies of a synthetic peptide fragment corresponding to the zinc-binding domain (101-141).

21 June 2018

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Reconstitution of human DNA repair excision nuclease in a highly defined system

21 June 2018

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Mammalian DNA nucleotide excision repair reconstituted with purified protein components.

21 June 2018

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The XPA protein is a zinc metalloprotein with an ability to recognize various kinds of DNA damage

21 June 2018

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Repair of damaged DNA by extracts from a xeroderma pigmentosum complementation group A revertant and expression of a protein absent in its parental cell line

21 June 2018

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DNA synthesis and repair genes RRM1 and ERCC1 in lung cancer.

21 June 2018

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Synthesis of Diverse Lactam Carboxamides Leading to the Discovery of a New Transcription-Factor Inhibitor

30 October 2018

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12 December 2020

Redefining cancer research

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12 December 2020

The genetics of the hereditary xeroderma pigmentosum syndrome

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12 December 2020

Defective repair of cisplatin-induced DNA damage caused by reduced XPA protein in testicular germ cell tumours

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12 December 2020

Identifiers

DOI

10.1021/CB1000444

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28 July 2017

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28 July 2017

1 reference