Late sodium current block for drug-induced long QT syndrome: Results from a prospective clinical trial (Q33647242)

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22 February 2020

title

Late sodium current block for drug-induced long QT syndrome: Results from a prospective clinical trial (English)

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22 February 2020

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22 February 2020

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22 February 2020

L Johannesen

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22 February 2020

J W Mason

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22 February 2020

C Erato

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22 February 2020

C Sanabria

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22 February 2020

K Waite-Labott

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22 February 2020

M Hong

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22 February 2020

J Lin

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22 February 2020

P Guo

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22 February 2020

A Mutlib

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22 February 2020

J Wang

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22 February 2020

W J Crumb

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22 February 2020

D Chan

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22 February 2020

J Stohlman

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22 February 2020

J Florian

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22 February 2020

N Stockbridge

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22 February 2020

D G Strauss

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22 February 2020

language of work or name

English

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publication date

28 November 2015

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Clinical Pharmacology & Therapeutics

22 February 2020

published in

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volume

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issue

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page(s)

214-223

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Comprehensive T wave morphology assessment in a randomized clinical study of dofetilide, quinidine, ranolazine, and verapamil

22 February 2020

cites work

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Inhibition of late sodium current by mexiletine: a novel pharmotherapeutical approach in timothy syndrome

28 July 2018

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Dealing with global safety issues : was the response to QT-liability of non-cardiac drugs well coordinated?

28 July 2018

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Suppression of phosphoinositide 3-kinase signaling and alteration of multiple ion currents in drug-induced long QT syndrome

28 July 2018

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Quantitative comparison of cardiac ventricular myocyte electrophysiology and response to drugs in human and nonhuman species.

28 July 2018

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Automatic extraction of ECG strips from continuous 12-lead holter recordings for QT analysis at prescheduled versus optimized time points.

28 July 2018

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Augmentation of late sodium current unmasks the proarrhythmic effects of amiodarone.

28 July 2018

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hERG potassium channels and cardiac arrhythmia

28 July 2018

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The utility of hERG and repolarization assays in evaluating delayed cardiac repolarization: influence of multi-channel block

28 July 2018

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Drug-induced prolongation of the QT interval

28 July 2018

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Relationships between preclinical cardiac electrophysiology, clinical QT interval prolongation and torsade de pointes for a broad range of drugs: evidence for a provisional safety margin in drug development

28 July 2018

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Pharmacological targeting of long QT mutant sodium channels

28 July 2018

1 reference

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Long QT syndrome patients with mutations of the SCN5A and HERG genes have differential responses to Na+ channel blockade and to increases in heart rate. Implications for gene-specific therapy.

28 July 2018

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HERG, a Human Inward Rectifier in the Voltage-Gated Potassium Channel Family

28 July 2018

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Adrenergic modulation of the delayed rectifier potassium channel in calf cardiac Purkinje fibers

28 July 2018

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Rechanneling the cardiac proarrhythmia safety paradigm: a meeting report from the Cardiac Safety Research Consortium

28 July 2018

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Results from the IQ-CSRC prospective study support replacement of the thorough QT study by QT assessment in the early clinical phase

21 January 2018

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Electrophysiological effects of ranolazine, a novel antianginal agent with antiarrhythmic properties

21 January 2018

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Differentiating drug-induced multichannel block on the electrocardiogram: randomized study of dofetilide, quinidine, ranolazine, and verapamil.

21 January 2018

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Improving the assessment of heart toxicity for all new drugs through translational regulatory science.

21 January 2018

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Functional effects of the late sodium current inhibition by AZD7009 and lidocaine in rabbit isolated atrial and ventricular tissue and Purkinje fibre

21 January 2018

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Screening for acute IKr block is insufficient to detect torsades de pointes liability: role of late sodium current.

21 January 2018

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Relationship between an arrhythmogenic action of lidocaine and its effects on excitation patterns in acutely ischemic porcine myocardium

21 January 2018

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International Conference on Harmonisation; guidance on E14 Clinical Evaluation of QT/QTc Interval Prolongation and Proarrhythmic Potential for Non-Antiarrhythmic Drugs; availability. Notice.

21 January 2018

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Actions of lidocaine on reentrant ventricular rhythms in the subacute myocardial infarction period in dogs

30 October 2018

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Profibrillatory Effects of Lidocaine in the Acutely Ischemic Porcine Heart

30 October 2018

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Mexiletine antagonizes effects of sotalol on QT interval duration and its proarrhythmic effects in a canine model of torsade de pointes

30 October 2018

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7 January 2021

A novel, potent, and selective inhibitor of cardiac late sodium current suppresses experimental arrhythmias

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7 January 2021

Sodium Channel Block With Mexiletine Is Effective in Reducing Dispersion of Repolarization and Preventing Torsade de Pointes in LQT2 and LQT3 Models of the Long-QT Syndrome

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7 January 2021

Reflex chronotropic and inotropic effects of calcium channel-blocking agents in conscious dogs. Diltiazem, verapamil, and nifedipine compared

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7 January 2021

Pharmacokinetics and elimination of moxifloxacin after oral and intravenous administration in man

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7 January 2021

Low dose quinidine-mexiletine combination therapy versus quinidine monotherapy for treatment of ventricular arrhythmias

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7 January 2021

Mexiletine-quinidine combination: electrophysiologic correlates of a favorable antiarrhythmic interaction in humans

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7 January 2021

Mexiletine in the treatment of resistant ventricular arrhythmias: enhancement of efficacy and reduction of dose-related side effects by combination with quinidine

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7 January 2021

Sex differences in the rate dependence of the T wave descending limb

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7 January 2021

Description of a nonselective cation current in human atrium

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7 January 2021

Identifiers

DOI

10.1002/CPT.205

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22 February 2020

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22 February 2020

PubMed publication ID

26259627

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