14-3-3gamma induces oncogenic transformation by stimulating MAP kinase and PI3K signaling (Q33632327)

28 July 2017

title

14-3-3gamma induces oncogenic transformation by stimulating MAP kinase and PI3K signaling (English)

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28 July 2017

author name string

Vijayababu M Radhakrishnan

series ordinal

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28 July 2017

Jesse D Martinez

series ordinal

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28 July 2017

language of work or name

English

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publication date

2 July 2010

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28 July 2017

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28 July 2017

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28 July 2017

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28 July 2017

page(s)

e11433

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Creative Commons Attribution 4.0 International

28 July 2017

start time

2 July 2010

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April 2022 Public Data File from Crossref

copyrighted

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cites work

14-3-3zeta Cooperates with ErbB2 to promote ductal carcinoma in situ progression to invasive breast cancer by inducing epithelial-mesenchymal transition

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The 14-3-3 proteins: integrators of diverse signaling cues that impact cell fate and cancer development

21 June 2018

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21 June 2018

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Sirt2 interacts with 14-3-3 beta/gamma and down-regulates the activity of p53

21 June 2018

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Up-regulation of 14-3-3zeta in lung cancer and its implication as prognostic and therapeutic target

21 June 2018

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Overexpression of 14-3-3gamma causes polyploidization in H322 lung cancer cells

21 June 2018

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Activity of TSC2 is inhibited by AKT-mediated phosphorylation and membrane partitioning

21 June 2018

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Phosphorylation and functional inactivation of TSC2 by Erk implications for tuberous sclerosis and cancer pathogenesis

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Transformation potential of Ras isoforms correlates with activation of phosphatidylinositol 3-kinase but not ERK.

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Enhanced expression of 14-3-3sigma in pancreatic cancer and its role in cell cycle regulation and apoptosis

21 June 2018

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The 14-3-3 cancer connection

21 June 2018

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Loss of Tsc1/Tsc2 activates mTOR and disrupts PI3K-Akt signaling through downregulation of PDGFR

21 June 2018

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14-3-3 interacts with the tumor suppressor tuberin at Akt phosphorylation site(s)

21 June 2018

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Regulation of TSC2 by 14-3-3 binding

21 June 2018

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Akt regulates growth by directly phosphorylating Tsc2

21 June 2018

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TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

21 June 2018

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Phosphatidylinositol 3-kinase/Akt pathway regulates tuberous sclerosis tumor suppressor complex by phosphorylation of tuberin

21 June 2018

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Efp targets 14-3-3 sigma for proteolysis and promotes breast tumour growth

21 June 2018

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14-3-3 proteins: active cofactors in cellular regulation by serine/threonine phosphorylation

21 June 2018

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Cell cycle roles for two 14-3-3 proteins during Drosophila development

21 June 2018

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The G2/M regulator 14-3-3sigma prevents apoptosis through sequestration of Bax

21 June 2018

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Mutation of somatostatin receptor type 5 in an acromegalic patient resistant to somatostatin analog treatment

21 June 2018

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Frequent hypermethylation of CpG islands and loss of expression of the 14-3-3 sigma gene in human hepatocellular carcinoma

21 June 2018

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Role of the beta isoform of 14-3-3 proteins in cellular proliferation and oncogenic transformation

21 June 2018

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Phosphoinositide 3-kinase forms a complex with platelet membrane glycoprotein Ib-IX-V complex and 14-3-3zeta

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2900177

High frequency of hypermethylation at the 14-3-3 sigma locus leads to gene silencing in breast cancer

21 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2900177

21 June 2018

Ras protein signalling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2900177

14-3-3sigma is a p53-regulated inhibitor of G2/M progression

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2900177

Mitotic and G 2 Checkpoint Control: Regulation of 14-3-3 Protein Binding by Phosphorylation of Cdc25C on Serine-216

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2900177

Phosphatidylinositol 3-kinase-independent signal transduction pathway for platelet-derived growth factor-induced chemotaxis

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2900177

Interaction of 14-3-3 with signaling proteins is mediated by the recognition of phosphoserine

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2900177

Activation of Raf-1 by Ras in intact cells

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2900177

Transformation of mammalian cells by constitutively active MAP kinase kinase

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2900177

Activation of Raf-1 by 14-3-3 proteins

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2900177

Regulation of Raf-1 kinase activity by the 14-3-3 family of proteins

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2900177

14-3-3 is not essential for Raf-1 function: identification of Raf-1 proteins that are biologically activated in a 14-3-3- and Ras-independent manner

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2900177

Human breast carcinoma cells transfected with the gene encoding a c-myc promoter-binding protein (MBP-1) inhibits tumors in nude mice

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2900177

Experimental metastatic ability of H-ras-transformed NIH3T3 cells.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2900177

Overexpression of normal human p53 in established fibroblasts leads to their tumorigenic conversion.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2900177

DNA damage-induced protein 14-3-3 sigma inhibits protein kinase B/Akt activation and suppresses Akt-activated cancer.

21 June 2018

1 reference

Crossref

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0011433

Isoform-specific expression of 14-3-3 proteins in human lung cancer tissues

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20628654

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1371/JOURNAL.PONE.0011433

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28 July 2017

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28 July 2017

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