Identification of a Novel Allosteric Inhibitory Site on Tryptophan Hydroxylase 1 Enabling Unprecedented Selectivity Over all Related Hydroxylases (Q33639498)

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English	Identification of a Novel Allosteric Inhibitory Site on Tryptophan Hydroxylase 1 Enabling Unprecedented Selectivity Over all Related Hydroxylases	scientific article

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20 March 2020

Identification of a Novel Allosteric Inhibitory Site on Tryptophan Hydroxylase 1 Enabling Unprecedented Selectivity Over all Related Hydroxylases (English)

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20 March 2020

Clemens Scheufler

17

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20 March 2020

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Mike Petrassi

1

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20 March 2020

Rob Barber

2

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20 March 2020

Celine Be

3

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20 March 2020

Sarah Beach

4

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20 March 2020

Brian Cox

5

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20 March 2020

Anne-Marie D'Souza

6

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20 March 2020

Nick Duggan

7

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20 March 2020

Martin Hussey

8

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20 March 2020

Roy Fox

9

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20 March 2020

Peter Hunt

10

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20 March 2020

Gabor Jarai

11

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20 March 2020

Takatoshi Kosaka

12

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20 March 2020

Paul Oakley

13

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20 March 2020

Viral Patel

14

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20 March 2020

Neil Press

15

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20 March 2020

David Rowlands

16

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20 March 2020

Oliver Schmidt

18

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20 March 2020

Honnappa Srinivas

19

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20 March 2020

Mary Turner

20

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20 March 2020

Rob Turner

21

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20 March 2020

John Westwick

22

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20 March 2020

Alison Wolfreys

23

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20 March 2020

Nuzhat Pathan

24

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20 March 2020

Simon Watson

25

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20 March 2020

Matthew Thomas

26

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20 March 2020

publication date

5 May 2017

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20 March 2020

Frontiers in Pharmacology

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20 March 2020

8

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20 March 2020

240

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20 March 2020

Transcriptome of pancreas-specific Bmpr1a-deleted islets links to TPH1-5-HT axis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5418348

14 July 2018

T lymphocytes possess the machinery for 5-HT synthesis, storage, degradation and release

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5418348

14 July 2018

Inhibiting peripheral serotonin synthesis reduces obesity and metabolic dysfunction by promoting brown adipose tissue thermogenesis

1 reference

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14 July 2018

Telotristat etiprate, a novel serotonin synthesis inhibitor, in patients with carcinoid syndrome and diarrhea not adequately controlled by octreotide

1 reference

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Safety of antipsychotic drugs: focus on therapeutic and adverse effects

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Sumatriptan (all routes of administration) for acute migraine attacks in adults - overview of Cochrane reviews

1 reference

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14 July 2018

Pharmacological reduction of mucosal but not neuronal serotonin opposes inflammation in mouse intestine

1 reference

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14 July 2018

Serotonergic drugs for depression and beyond

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14 July 2018

Targeting the serotonin pathway for the treatment of pulmonary arterial hypertension

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Randomised clinical trial: alosetron improves quality of life and reduces restriction of daily activities in women with severe diarrhoea-predominant IBS.

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14 July 2018

Gene therapy by targeted adenovirus-mediated knockdown of pulmonary endothelial Tph1 attenuates hypoxia-induced pulmonary hypertension

1 reference

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14 July 2018

The Tryptophan Hydroxylase Inhibitor LX1031 Shows Clinical Benefit in Patients With Nonconstipating Irritable Bowel Syndrome

1 reference

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14 July 2018

5-HT and the immune system

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14 July 2018

Mechanism of Inhibition of Novel Tryptophan Hydroxylase Inhibitors Revealed by Co-crystal Structures and Kinetic Analysis

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14 July 2018

The expanded biology of serotonin

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14 July 2018

Fibrosis and carcinoid syndrome: from causation to future therapy

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5418348

14 July 2018

Modulation of peripheral serotonin levels by novel tryptophan hydroxylase inhibitors for the potential treatment of functional gastrointestinal disorders

1 reference

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14 July 2018

Discovery and characterization of novel tryptophan hydroxylase inhibitors that selectively inhibit serotonin synthesis in the gastrointestinal tract

1 reference

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14 July 2018

Serotonin secretion by human carcinoid BON cells

1 reference

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14 July 2018

Disruption of the nonneuronal tph1 gene demonstrates the importance of peripheral serotonin in cardiac function

1 reference

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14 July 2018

A unique central tryptophan hydroxylase isoform

1 reference

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14 July 2018

Synthesis of serotonin by a second tryptophan hydroxylase isoform

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14 July 2018

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14 July 2018

Tryptophan hydroxylation: measurement in pineal gland, brainstem, and carcinoid tumor

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14 July 2018

Inhibition of gut- and lung-derived serotonin attenuates pulmonary hypertension in mice

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21 January 2018

Imatinib attenuates hypoxia-induced pulmonary arterial hypertension pathology via reduction in 5-hydroxytryptamine through inhibition of tryptophan hydroxylase 1 expression.

1 reference

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21 January 2018

Cross talk between endothelial and smooth muscle cells in pulmonary hypertension: critical role for serotonin-induced smooth muscle hyperplasia.

1 reference

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21 January 2018

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1 reference

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21 January 2018

Robust and tissue-specific expression of TPH2 versus TPH1 in rat raphe and pineal gland

1 reference

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21 January 2018

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1 reference

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21 January 2018

Effect of Tryptophan Hydroxylase 1 Deficiency on the Development of Hypoxia-Induced Pulmonary Hypertension

1 reference

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21 January 2018

Gateways to clinical trials

1 reference

https://pubmed.ncbi.nlm.nih.gov/28529483

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of Serotonin Synthesis by Para-Chlorophenylalanine in Patients with the Carcinoid Syndrome

1 reference

https://pubmed.ncbi.nlm.nih.gov/28529483

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Serotonin passes through myoendothelial gap junctions to promote pulmonary arterial smooth muscle cell differentiation

1 reference

https://pubmed.ncbi.nlm.nih.gov/28529483

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Terguride ameliorates monocrotaline-induced pulmonary hypertension in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/28529483

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.3389/FPHAR.2017.00240

1 reference

Europe PubMed Central

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20 March 2020

PMC publication ID

1 reference

Europe PubMed Central

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20 March 2020

PubMed publication ID

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Europe PubMed Central

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20 March 2020

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