Efficacy of posaconazole against three clinical Aspergillus fumigatus isolates with mutations in the cyp51A gene. (Q33613758)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19917751%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

title

Efficacy of posaconazole against three clinical Aspergillus fumigatus isolates with mutations in the cyp51A gene (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19917751%20AND%20SRC:MED&resulttype=core&format=json

14-alpha sterol demethylase

12 February 2020

main subject

Aspergillus fumigatus

0 references

1 reference

6 February 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19917751%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19917751%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

Eleftheria Mavridou

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19917751%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

Roger J M Brüggemann

series ordinal

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19917751%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

Johan W Mouton

series ordinal

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19917751%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

language of work or name

English

0 references

publication date

16 November 2009

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19917751%20AND%20SRC:MED&resulttype=core&format=json

Antimicrobial Agents and Chemotherapy

12 February 2020

published in

1 reference

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12 February 2020

volume

1 reference

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12 February 2020

issue

1 reference

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12 February 2020

page(s)

860-865

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19917751%20AND%20SRC:MED&resulttype=core&format=json

Frequency and evolution of Azole resistance in Aspergillus fumigatus associated with treatment failure

12 February 2020

cites work

1 reference

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Emergence of azole resistance in Aspergillus fumigatus and spread of a single resistance mechanism

21 June 2018

1 reference

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In vitro activities at pH 5.0 and pH 7.0 and in vivo efficacy of flucytosine against Aspergillus fumigatus.

21 June 2018

1 reference

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Establishing in vitro-in vivo correlations for Aspergillus fumigatus: the challenge of azoles versus echinocandins.

21 June 2018

1 reference

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A new Aspergillus fumigatus resistance mechanism conferring in vitro cross-resistance to azole antifungals involves a combination of cyp51A alterations.

21 June 2018

1 reference

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Pharmacokinetics, safety, and efficacy of posaconazole in patients with persistent febrile neutropenia or refractory invasive fungal infection

21 June 2018

1 reference

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Disposition of posaconazole following single-dose oral administration in healthy subjects

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2812170

Substitutions at methionine 220 in the 14alpha-sterol demethylase (Cyp51A) of Aspergillus fumigatus are responsible for resistance in vitro to azole antifungal drugs

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2812170

Pharmacodynamics of a new triazole, posaconazole, in a murine model of disseminated candidiasis

21 June 2018

1 reference

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Pharmacokinetics, safety, and tolerability of oral posaconazole administered in single and multiple doses in healthy adults

21 June 2018

1 reference

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Multiple resistance mechanisms among Aspergillus fumigatus mutants with high-level resistance to itraconazole.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2812170

Mutations in Aspergillus fumigatus resulting in reduced susceptibility to posaconazole appear to be restricted to a single amino acid in the cytochrome P450 14alpha-demethylase

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2812170

Identification of two different 14-alpha sterol demethylase-related genes (cyp51A and cyp51B) in Aspergillus fumigatus and other Aspergillus species

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2812170

Acquired itraconazole resistance in Aspergillus fumigatus

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2812170

Pharmacokinetics of SCH 56592, a new azole broad-spectrum antifungal agent, in mice, rats, rabbits, dogs, and cynomolgus monkeys

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2812170

Aspergillus fumigatus and aspergillosis

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2812170

Itraconazole resistance in Aspergillus fumigatus

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2812170

Infections with Aspergillus species.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2812170

Azole-resistant central nervous system aspergillosis.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2812170

Dose-response relationships of three amphotericin B formulations in a non-neutropenic murine model of invasive aspergillosis.

30 October 2018

1 reference

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Multiple-azole-resistant Aspergillus fumigatus osteomyelitis in a patient with chronic granulomatous disease successfully treated with long-term oral posaconazole and surgery.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2812170

International interlaboratory proficiency testing program for measurement of azole antifungal plasma concentrations

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2812170

Mutations in the cyp51A gene and susceptibility to itraconazole in Aspergillus fumigatus serially isolated from a patient with lung aspergilloma

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2812170

Identification of human UDP-glucuronosyltransferase enzyme(s) responsible for the glucuronidation of posaconazole (Noxafil).

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2812170

Multidrug resistance in Aspergillus fumigatus.

30 October 2018

1 reference

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A comparative study of the in vitro susceptibilities of clinical and laboratory-selected resistant isolates of Aspergillus spp. to amphotericin B, itraconazole, voriconazole and posaconazole (SCH 56592).

30 October 2018

1 reference

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Secular trends in the epidemiology of nosocomial fungal infections in the United States, 1980-1990. National Nosocomial Infections Surveillance System.

30 October 2018

1 reference

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Use of voriconazole in a patient with aspergilloma caused by an itraconazole-resistant strain of Aspergillus fumigatus

30 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19917751

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Aspergillosis—and a misleading sensitivity result

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19917751

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Multiple-Triazole–Resistant Aspergillosis

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19917751

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1128/AAC.00931-09

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19917751%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19917751%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

PubMed publication ID

19917751

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19917751%20AND%20SRC:MED&resulttype=core&format=json