Homeostatic imbalance of regulatory and effector T cells due to IL-2 deprivation amplifies murine lupus (Q33591655)

28 July 2017

title

Homeostatic imbalance of regulatory and effector T cells due to IL-2 deprivation amplifies murine lupus (English)

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28 July 2017

Alexander Scheffold

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Gerd-Rüdiger Burmester

object named as

Gerd-Rüdiger Burmester

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Gabriela Riemekasten

object named as

Gabriela Riemekasten

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28 July 2017

Andreas Radbruch

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28 July 2017

Reinmar Undeutsch

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28 July 2017

Lutz Kloke

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28 July 2017

Jens Y Humrich

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28 July 2017

Henner Morbach

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28 July 2017

Philipp Enghard

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28 July 2017

Stefan Rosenberger

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28 July 2017

Olivia Weigert

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28 July 2017

Juliane Heimann

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28 July 2017

Timo Gaber

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28 July 2017

Susan Brandenburg

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28 July 2017

Jochen Huehn

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28 July 2017

language of work or name

English

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publication date

14 December 2009

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Proceedings of the National Academy of Sciences of the United States of America

28 July 2017

published in

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28 July 2017

volume

107

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28 July 2017

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28 July 2017

page(s)

204-209

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Central role of defective interleukin-2 production in the triggering of islet autoimmune destruction

28 July 2017

cites work

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806746

Human regulatory T cells and autoimmunity

21 June 2018

1 reference

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The biology of interleukin-2.

21 June 2018

1 reference

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TLR-dependent and TLR-independent pathways of type I interferon induction in systemic autoimmunity

21 June 2018

1 reference

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Interleukin-2 gene variation impairs regulatory T cell function and causes autoimmunity

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806746

Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice

21 June 2018

1 reference

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Sequential development of interleukin 2-dependent effector and regulatory T cells in response to endogenous systemic antigen

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806746

A function for interleukin 2 in Foxp3-expressing regulatory T cells

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806746

Development and function of agonist-induced CD25+Foxp3+ regulatory T cells in the absence of interleukin 2 signaling

21 June 2018

1 reference

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21 June 2018

Key autoantigens in SLE.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806746

Systemic lupus erythematosus serum IgG increases CREM binding to the IL-2 promoter and suppresses IL-2 production through CaMKIV

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806746

Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806746

Homeostatic maintenance of natural Foxp3(+) CD25(+) CD4(+) regulatory T cells by interleukin (IL)-2 and induction of autoimmune disease by IL-2 neutralization

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806746

Foxp3 programs the development and function of CD4+CD25+ regulatory T cells

21 June 2018

1 reference

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Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene

21 June 2018

1 reference

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Generalized autoimmune disease in interleukin-2-deficient mice is triggered by an uncontrolled activation and proliferation of CD4+ T cells

21 June 2018

1 reference

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Recovery from autoimmunity of MRL/lpr mice after infection with an interleukin-2/vaccinia recombinant virus

21 June 2018

1 reference

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IL-2 induces in vivo suppression by CD4(+)CD25(+)Foxp3(+) regulatory T cells.

21 June 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0903158107

Suppression of disease in New Zealand Black/New Zealand White lupus-prone mice by adoptive transfer of ex vivo expanded regulatory T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0903158107

Depletion of autoreactive immunologic memory followed by autologous hematopoietic stem cell transplantation in patients with refractory SLE induces long-term remission through de novo generation of a juvenile and tolerant immune system

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0903158107

Modulation of autoimmune disease in the MRL-lpr/lpr mouse by IL-2 and TGF-beta1 gene therapy using attenuated Salmonella typhimurium as gene carrier

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0903158107

Interleukin-2 and systemic lupus erythematosus--fifteen years later

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0903158107

Global Natural Regulatory T Cell Depletion in Active Systemic Lupus Erythematosus

21 January 2018

1 reference

12 December 2020

IL-6 produced by dendritic cells from lupus-prone mice inhibits CD4+CD25+ T cell regulatory functions

1 reference

12 December 2020

CD4 regulatory T cells prevent lethal autoimmunity in IL-2Rbeta-deficient mice. Implications for the nonredundant function of IL-2

1 reference

12 December 2020

Interleukin 2 deficiency is a common feature of autoimmune mice

1 reference

12 December 2020

Defective production of interleukin 1 and interleukin 2 in patients with systemic lupus erythematosus (SLE)

1 reference

12 December 2020

Murine lupus susceptibility locus Sle1a controls regulatory T cell number and function through multiple mechanisms

1 reference

12 December 2020

Murine models of systemic lupus erythematosus

1 reference

12 December 2020

Deregulated T cell activation and autoimmunity in mice lacking interleukin-2 receptor beta

1 reference

12 December 2020

Systemic lupus erythematosus

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.0903158107

1 reference

28 July 2017

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28 July 2017

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