Aprotinin: an update of its pharmacology and therapeutic use in open heart surgery and coronary artery bypass surgery (Q33585385)

28 July 2017

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title

Aprotinin: an update of its pharmacology and therapeutic use in open heart surgery and coronary artery bypass surgery (English)

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coronary artery bypass surgery

28 July 2017

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D C Peters

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28 July 2017

S Noble

series ordinal

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28 July 2017

publication date

1 February 1999

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28 July 2017

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28 July 2017

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28 July 2017

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28 July 2017

page(s)

233-260

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A comparison of the effects of tranexamic acid and low-dose aprotinin on blood loss and homologous blood usage in patients undergoing cardiac surgery

28 July 2017

cites work

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12 December 2020

[Fibrinolytic inhibitors and prevention of bleeding in cardiac valve surgery. Comparison of tranexamic acid and high dose aprotinin]

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12 December 2020

Current methods to reduce the adverse haematological consequences of cardiopulmonary bypass.

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12 December 2020

Aprotinin but not tranexamic acid inhibits cytokine-induced inducible nitric oxide synthase expression

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12 December 2020

Aprotinin for prophylaxis of blood loss

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12 December 2020

Aprotinin effects related to oxidative stress in cardiosurgery with mechanical cardiorespiratory support (CMCS)

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12 December 2020

Myocardial contractile dysfunction in the systemic inflammatory response syndrome: role of a cytokine-inducible nitric oxide synthase in cardiac myocytes.

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12 December 2020

Cost-benefit and efficacy of aprotinin compared with epsilon-aminocaproic acid in patients having repeated cardiac operations: a randomized, blinded clinical trial

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12 December 2020

Prospective, randomized, double-blind study of high-dose aprotinin in pediatric cardiac operations

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12 December 2020

Suppressed fibrinolysis after administration of low-dose aprotinin: reduced level of plasmin-alpha2-plasmin inhibitor complexes and postoperative blood loss

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12 December 2020

Influence of high-dose aprotinin on anticoagulation, heparin requirement, and celite- and kaolin-activated clotting time in heparin-pretreated patients undergoing open-heart surgery. A double-blind, placebo-controlled study

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12 December 2020

Routine intraoperative application of high-dose aprotinin in open heart surgery in adults: antibody formation after first exposure.

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12 December 2020

Hematologic and economic impact of aprotinin in reoperative pediatric cardiac operations

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12 December 2020

Effects of high-dose aprotinin on renal function in aortocoronary bypass grafting

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12 December 2020

Beneficial effects and improved survival in rodent models of septic shock with S-methylisothiourea sulfate, a potent and selective inhibitor of inducible nitric oxide synthase

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12 December 2020

The effect on costs of the use of half-dose aprotinin for first-time reoperative coronary artery bypass patients

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12 December 2020

Aprotinin and methylprednisolone equally blunt cardiopulmonary bypass-induced inflammation in humans

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12 December 2020

Variability in transfusion practice for coronary artery bypass surgery persists despite national consensus guidelines: a 24-institution study. Institutions of the Multicenter Study of Perioperative Ischemia Research Group

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12 December 2020

Drugs to minimize perioperative blood loss in cardiac surgery: meta-analyses using perioperative blood transfusion as the outcome. The International Study of Peri-operative Transfusion (ISPOT) Investigators

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12 December 2020

The efficacy and cost of aprotinin in children undergoing reoperative open heart surgery.

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12 December 2020

Fatal anaphylactic shock after aprotinin reexposure in cardiac surgery

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12 December 2020

Expression of inducible nitric oxide synthase in human heart failure

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12 December 2020

Blood-sparing drugs: aprotinin, tranexamic acid, and epsilon-aminocaproic acid.

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12 December 2020

Prevalence of anaphylactic reactions to aprotinin: analysis of two hundred forty-eight reexposures to aprotinin in heart operations

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12 December 2020

Aprotinin: safe and effective only with the full-dose regimen

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12 December 2020

Pharmacokinetics of aprotinin in preoperative cardiac surgical patients

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12 December 2020

Pharmacokinetics of aprotinin in two patients with chronic renal impairment

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12 December 2020

Effect of aprotinin (Trasylol) on aorta-coronary bypass graft patency

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12 December 2020

Analyses of coronary graft patency after aprotinin use: results from the International Multicenter Aprotinin Graft Patency Experience (IMAGE) trial

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12 December 2020

Aprotinin protects against myocardial and oxidant formation and endothelial cell damage during open heart surgery

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12 December 2020

A multicenter, double-blind, placebo-controlled trial of aprotinin for reducing blood loss and the requirement for donor-blood transfusion in patients undergoing repeat coronary artery bypass grafting

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12 December 2020

Aprotinin in primary valve replacement and reconstruction: a multicenter, double-blind, placebo-controlled trial

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12 December 2020

A Review of Post--Cardiopulmonary Bypass Bleeding, Aminocaproic Acid, Tranexamic Acid, and Aprotinin

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12 December 2020

The Impact of Aprotinin on Coronary Artery Bypass Graft Patency

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12 December 2020

Intraoperative antifibrinolysis and blood-saving techniques in cardiac surgery. Prospective trial of 3 antifibrinolytic drugs

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12 December 2020

Aprotinin reduces nitric oxide production in vitro and in vivo in a dose-dependent manner

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12 December 2020

A pump-prime aprotinin dose in cardiac surgery: Appraisal of its effects on the hemostatic system

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12 December 2020

Severe anaphylactic shock due to repeated application of aprotinin in patients following intrathoracic aortic replacement

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12 December 2020

Changes in coagulation patterns, blood loss and blood use after cardiopulmonary bypass: aprotinin vs tranexamic acid vs epsilon aminocaproic acid.

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12 December 2020

IgE-mediated anaphylactic reaction to aprotinin during anaesthesia

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12 December 2020

Anaphylactic reaction to aprotinin despite negative ocular sensitivity tests

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12 December 2020

Maintenance of therapeutic plasma aprotinin levels during prolonged cardiopulmonary bypass using a large-dose regimen

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12 December 2020

High dose aprotinin reduces prothrombin and fibrinogen conversion in patients undergoing extracorporeal circulation for myocardial revascularization

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12 December 2020

Aprotinin has no effect on platelet activation and adhesion during cardiopulmonary bypass

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12 December 2020

Reduction in Costs, Blood Products, and Operating Time in Patients Undergoing Open Heart Surgery

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12 December 2020

Examination of the biological safety of a drug derived from mammalian organs

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12 December 2020

Effects of minimal-dose aprotinin on coronary artery bypass grafting

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12 December 2020

Modifying risk for extracorporeal circulation: trial of four antiinflammatory strategies

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12 December 2020

A Risk-Benefit Assessment of Aprotinin in Cardiac Surgical Procedures

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12 December 2020

Aprotinin Enhances the Endogenous Release of Interleukin-10 After Cardiac Operations

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12 December 2020

"Low-dose" aprotinin modifies hemostasis but not proinflammatory cytokine release.

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12 December 2020

Postoperative hemostasis and fibrinolysis in patients undergoing cardiopulmonary bypass with or without aprotinin therapy

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12 December 2020

Long-term follow-up of aprotinin-specific immunoglobulin g antibodies after cardiac operations

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12 December 2020

A brief review of studies evaluating the adverse effects of aprotinin therapy in aortocoronary bypass surgery

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12 December 2020

Methylprednisolone and full-dose aprotinin reduce reperfusion injury after cardiopulmonary bypass

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12 December 2020

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12 December 2020

Re-graft patency and clinical efficacy of aprotinin in elective bypass surgery

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12 December 2020

Preventing the inflammatory response to open-heart surgery: the role of aprotinin and other protease inhibitors

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12 December 2020

Natural and synthetic antifibrinolytics: Inert, poisonous or therapeutic agents?

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12 December 2020

Aprotinin in patients having coronary artery bypass graft surgery.

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12 December 2020

Cardiopulmonary bypass and the inflammatory response: a role for serine protease inhibitors?

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12 December 2020

Aprotinin versus desmopressin for patients undergoing operations with cardiopulmonary bypass. A double-blind placebo-controlled study

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12 December 2020

Influence of aprotinin on the thrombomodulin/protein C system in pediatric cardiac operations.

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12 December 2020

Conservation of blood during cardiovascular surgery

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12 December 2020

Aprotinin in pediatric cardiac operations: a benefit in complex malformations and with high-dose regimen only

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12 December 2020

The use of low-dose aprotinin, epsilon-aminocaproic acid or tranexamic acid for prevention of mediastinal bleeding in patients receiving aspirin before coronary artery bypass operations

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12 December 2020

Mechanisms of thrombin generation during surgery and cardiopulmonary bypass

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12 December 2020

High-dose epsilon-aminocaproic acid versus aprotinin: antifibrinolytic efficacy in first-time coronary operations

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12 December 2020

High-dose aprotinin in cardiac surgery: three years' experience in 1,784 patients

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12 December 2020

Efficacy of aprotinin in different doses and autologous blood transfusions in cardiac surgery

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12 December 2020

Aprotinin for primary coronary artery bypass grafting: a multicenter trial of three dose regimens

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12 December 2020

The blood saving potential of vortex versus roller pump with and without aprotinin

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12 December 2020

Low-dose and high-dose aprotinin improve hemostasis in coronary operations

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12 December 2020

Aprotinin. A review of its pharmacology and therapeutic efficacy in reducing blood loss associated with cardiac surgery

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12 December 2020

Aprotinin use in patients with dialysis-dependent renal failure undergoing cardiac operations

1 reference

12 December 2020

Apoptosis of cardiac myocytes during cardiac allograft rejection. Relation to induction of nitric oxide synthase

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12 December 2020

[Anaphylactic shock during the use of high doses of aprotinin in cardiac surgery]

1 reference

12 December 2020

Reduction of the infectivity of scrapie agent as a model for BSE in the manufacturing process of Trasylol

1 reference

12 December 2020

Aprotinin for coronary bypass operations: efficacy, safety, and influence on early saphenous vein graft patency. A multicenter, randomized, double-blind, placebo-controlled study

1 reference

12 December 2020

Tranexamic acid and aprotinin reduce postoperative bleeding and transfusions during primary coronary revascularization

1 reference

12 December 2020

Differing effects of aprotinin and epsilon-aminocaproic acid on cytokine-induced inducible nitric oxide synthase expression

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12 December 2020

1 reference

12 December 2020

Aprotinin modulation of platelet activation in patients undergoing cardiopulmonary bypass operations

1 reference

12 December 2020

Aprotinin reduces blood loss after cardiopulmonary bypass by direct inhibition of plasmin

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12 December 2020

Anaphylactic reaction to aprotinin during cardiac surgery.

1 reference

12 December 2020

Aprotinin therapy in cardiac operations: a report on use in 41 cardiac centers in the United Kingdom

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12 December 2020

Metaanalysis of prophylactic drug treatment in the prevention of postoperative bleeding

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12 December 2020

Aprotinin reduces interleukin-8 production and lung neutrophil accumulation after cardiopulmonary bypass

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12 December 2020

Influence of low-dose aprotinin on the inflammatory reaction due to cardiopulmonary bypass in children

1 reference

12 December 2020

Influence of High- and Low-Dose Aprotinin on Activation of Hemostasis in Open Heart Operations

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12 December 2020

Coagulation in cardiac surgery

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12 December 2020

Comparison of the effects of aprotinin and tranexamic acid on blood loss and related variables after cardiopulmonary bypass

1 reference

12 December 2020

10.2165/00003495-199957020-00015

Identifiers

DOI

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Dimensions Publication ID

28 July 2017

1040474159

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