Antitumor and antiangiogenic effect of the dual EGFR and HER-2 tyrosine kinase inhibitor lapatinib in a lung cancer model (Q33575434)

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2 February 2020

title

Antitumor and antiangiogenic effect of the dual EGFR and HER-2 tyrosine kinase inhibitor lapatinib in a lung cancer model (English)

1 reference

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2 February 2020

main subject

angiogenesis inhibitor

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2 February 2020

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2 February 2020

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2 February 2020

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2 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20459769%20AND%20SRC:MED&resulttype=core&format=json

2 February 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20459769%20AND%20SRC:MED&resulttype=core&format=json

2 February 2020

Ricardo Parrondo

1 reference

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2 February 2020

Carlos Perez-Stable

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2 February 2020

Irene Manrique

1 reference

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2 February 2020

Raul Catena

1 reference

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2 February 2020

Juan Antonio Díaz-González

1 reference

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2 February 2020

language of work or name

English

0 references

publication date

11 May 2010

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2 February 2020

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2 February 2020

volume

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2 February 2020

page(s)

188

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Synergistic proapoptotic effects of the two tyrosine kinase inhibitors pazopanib and lapatinib on multiple carcinoma cell lines

2 February 2020

cites work

1 reference

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Screening for epidermal growth factor receptor mutations in lung cancer

21 June 2018

1 reference

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21 June 2018

Cancer statistics, 2009

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The growth inhibitory effect of lapatinib, a dual inhibitor of EGFR and HER2 tyrosine kinase, in gastric cancer cell lines

21 June 2018

1 reference

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Combined targeting of EGFR-dependent and VEGF-dependent pathways: rationale, preclinical studies and clinical applications

21 June 2018

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Lapatinib resistance in HCT116 cells is mediated by elevated MCL-1 expression and decreased BAK activation and not by ERBB receptor kinase mutation

21 June 2018

1 reference

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Phase II trial of lapatinib for brain metastases in patients with human epidermal growth factor receptor 2-positive breast cancer

21 June 2018

1 reference

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The inhibitor of apoptosis proteins as therapeutic targets in cancer

21 June 2018

1 reference

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Assessment of epidermal growth factor receptor (EGFR, ErbB1) and HER2 (ErbB2) protein expression levels and response to lapatinib (Tykerb, GW572016) in an expanded panel of human normal and tumour cell lines

21 June 2018

1 reference

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Bcl-2-regulated apoptosis: mechanism and therapeutic potential

21 June 2018

1 reference

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EGFR targeting of solid tumors

21 June 2018

1 reference

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Erlotinib, an effective epidermal growth factor receptor tyrosine kinase inhibitor, induces p27KIP1 up-regulation and nuclear translocation in association with cell growth inhibition and G1/S phase arrest in human non-small-cell lung cancer cell lin

21 June 2018

1 reference

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Lapatinib plus capecitabine for HER2-positive advanced breast cancer

21 June 2018

1 reference

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The multifaceted circulating endothelial cell in cancer: towards marker and target identification.

21 June 2018

1 reference

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Cyclin A but not cyclin D1 is essential for c-myc-modulated cell-cycle progression

21 June 2018

1 reference

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Activity of the dual kinase inhibitor lapatinib (GW572016) against HER-2-overexpressing and trastuzumab-treated breast cancer cells

21 June 2018

1 reference

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Gefitinib plus best supportive care in previously treated patients with refractory advanced non-small-cell lung cancer: results from a randomised, placebo-controlled, multicentre study (Iressa Survival Evaluation in Lung Cancer)

21 June 2018

1 reference

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The epidermal growth factor receptor tyrosine kinase inhibitor ZD1839 selectively potentiates radiation response of human tumors in nude mice, with a marked improvement in therapeutic index.

21 June 2018

1 reference

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Epidermal growth factor receptor in non-small-cell lung carcinomas: correlation between gene copy number and protein expression and impact on prognosis.

21 June 2018

1 reference

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Epidermal growth factor family of receptors in preneoplasia and lung cancer: perspectives for targeted therapies

21 June 2018

1 reference

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Comparison of four chemotherapy regimens for advanced non-small-cell lung cancer

21 June 2018

1 reference

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EGFR and cancer prognosis

21 June 2018

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Randomized phase III trial of paclitaxel plus carboplatin versus vinorelbine plus cisplatin in the treatment of patients with advanced non--small-cell lung cancer: a Southwest Oncology Group trial

21 June 2018

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Molecular profiling of computed tomography screen-detected lung nodules shows multiple malignant features.

21 June 2018

1 reference

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Genome-wide DNA copy number predictors of lapatinib sensitivity in tumor-derived cell lines

21 January 2018

1 reference

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Phase I study of lapatinib in combination with chemoradiation in patients with locally advanced squamous cell carcinoma of the head and neck

21 January 2018

1 reference

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Bone marrow origin of cells with capacity for homing and differentiation to esophageal squamous epithelium

21 January 2018

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Efficacy and safety of lapatinib as first-line therapy for ErbB2-amplified locally advanced or metastatic breast cancer

21 January 2018

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Usefulness of FDG-PET for early prediction of the response to gefitinib in non-small cell lung cancer

21 January 2018

1 reference

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Dual inhibition of epidermal growth factor receptor and vascular endothelial growth factor receptor phosphorylation by AEE788 reduces growth and metastasis of human colon carcinoma in an orthotopic nude mouse model

21 January 2018

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Identification and clinical significance of circulating endothelial progenitor cells in human non-small cell lung cancer.

21 January 2018

1 reference

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Bone marrow from CD18-/- (MAC-1-/-) homozygous deletion recombinant negative mice demonstrates increased longevity in long-term bone marrow culture and decreased contribution to irradiation pulmonary damage

21 January 2018

1 reference

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Maximum tolerable dose and low-dose metronomic chemotherapy have opposite effects on the mobilization and viability of circulating endothelial progenitor cells.

31 October 2018

1 reference

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Blockade of the epidermal growth factor receptor signaling by a novel tyrosine kinase inhibitor leads to apoptosis of endothelial cells and therapy of human pancreatic carcinoma

31 October 2018

1 reference

12 December 2020

Effects of total body irradiation on the vascular endothelium

1 reference

12 December 2020

Circulating endothelial cells as a marker of endothelial damage in allogeneic hematopoietic stem cell transplantation

1 reference

12 December 2020

Overexpression of the epidermal growth factor receptor and its ligand transforming growth factor alpha is frequent in resectable non-small cell lung cancer but does not predict tumor progression

1 reference

12 December 2020

Identifiers

DOI

10.1186/1471-2407-10-188

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20459769%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

2 February 2020

0 references

1 reference

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2 February 2020

PubMed publication ID

20459769

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20459769%20AND%20SRC:MED&resulttype=core&format=json