The SIRT1 activator SRT1720 extends lifespan and improves health of mice fed a standard diet (Q33566310)

28 July 2017

title

The SIRT1 activator SRT1720 extends lifespan and improves health of mice fed a standard diet (English)

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28 July 2017

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28 July 2017

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28 July 2017

Michel Bernier

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Rafael de Cabo

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Sarah J Mitchell

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28 July 2017

Alejandro Martin-Montalvo

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28 July 2017

Evi M Mercken

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28 July 2017

Hector H Palacios

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28 July 2017

Theresa M Ward

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28 July 2017

Gelareh Abulwerdi

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28 July 2017

Robin K Minor

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28 July 2017

George P Vlasuk

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28 July 2017

James L Ellis

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28 July 2017

John Dawson

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28 July 2017

Yongqing Zhang

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28 July 2017

Kevin G Becker

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28 July 2017

publication date

27 February 2014

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28 July 2017

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28 July 2017

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28 July 2017

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28 July 2017

page(s)

836-843

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Metformin improves healthspan and lifespan in mice

28 July 2017

cites work

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21 June 2018

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21 June 2018

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Sirtuin 1 activator SRT1720 suppresses inflammation in an ovalbumin-induced mouse model of asthma

21 June 2018

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Impaired SIRT1 nucleocytoplasmic shuttling in the senescent heart during ischemic stress

21 June 2018

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SIRT1 protects against emphysema via FOXO3-mediated reduction of premature senescence in mice

21 June 2018

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SRT1720, a SIRT1 activator, promotes tumor cell migration, and lung metastasis of breast cancer in mice

21 June 2018

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21 June 2018

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Evaluation of resveratrol, green tea extract, curcumin, oxaloacetic acid, and medium-chain triglyceride oil on life span of genetically heterogeneous mice

21 June 2018

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Activating transcription factor 4 confers a multidrug resistance phenotype to gastric cancer cells through transactivation of SIRT1 expression

21 June 2018

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SRT1720 improves survival and healthspan of obese mice

21 June 2018

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Fasting cycles retard growth of tumors and sensitize a range of cancer cell types to chemotherapy

21 June 2018

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Chronic mTOR inhibition by rapamycin induces muscle insulin resistance despite weight loss in rats

21 June 2018

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Anticancer effects of 15d-prostaglandin-J2 in wild-type and doxorubicin-resistant ovarian cancer cells: novel actions on SIRT1 and HDAC

21 June 2018

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Preclinical evaluation of a novel SIRT1 modulator SRT1720 in multiple myeloma cells

21 June 2018

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21 June 2018

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Life span extension via eIF4G inhibition is mediated by posttranscriptional remodeling of stress response gene expression in C. elegans

21 June 2018

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Structural basis of SETD6-mediated regulation of the NF-kB network via methyl-lysine signaling

21 June 2018

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Negative regulation of STAT3 protein-mediated cellular respiration by SIRT1 protein

21 June 2018

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Sirt1-Independent Mechanisms of the Putative Sirtuin Enzyme Activators SRT1720 and SRT2183

21 June 2018

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Regulation of hepatic cytochromes p450 by lipids and cholesterol.

21 June 2018

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Amurensin G, a potent natural SIRT1 inhibitor, rescues doxorubicin responsiveness via down-regulation of multidrug resistance 1

21 June 2018

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Chronic rapamycin treatment causes glucose intolerance and hyperlipidemia by upregulating hepatic gluconeogenesis and impairing lipid deposition in adipose tissue

21 June 2018

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The mitochondrial ribosomal protein of the large subunit, Afo1p, determines cellular longevity through mitochondrial back-signaling via TOR1.

21 June 2018

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SRT1720, SRT2183, SRT1460, and resveratrol are not direct activators of SIRT1

21 June 2018

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Treatment with SRT1720, a SIRT1 activator, ameliorates fatty liver with reduced expression of lipogenic enzymes in MSG mice.

21 June 2018

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Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

21 June 2018

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SirT1 gain of function increases energy efficiency and prevents diabetes in mice

21 June 2018

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Sirt1 protects against high-fat diet-induced metabolic damage

21 June 2018

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Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span

21 June 2018

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Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes

21 June 2018

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Resveratrol improves health and survival of mice on a high-calorie diet

21 June 2018

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PAGE: parametric analysis of gene set enrichment

21 June 2018

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Suppressors of cytokine signaling and immunity

21 June 2018

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Analysis of microarray data using Z score transformation

21 June 2018

1 reference

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Inflamm-aging. An evolutionary perspective on immunosenescence

21 June 2018

1 reference

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NF-kappaB activation by tumour necrosis factor requires the Akt serine-threonine kinase

21 June 2018

1 reference

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Positive and negative regulation of IkappaB kinase activity through IKKbeta subunit phosphorylation

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4010117

The SCFbeta-TRCP-ubiquitin ligase complex associates specifically with phosphorylated destruction motifs in IkappaBalpha and beta-catenin and stimulates IkappaBalpha ubiquitination in vitro

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4010117

Specific SIRT1 activation mimics low energy levels and protects against diet-induced metabolic disorders by enhancing fat oxidation

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4010117

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4010117

Glycogen synthase kinase-3 beta regulates NF-kappa B1/p105 stability

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4010117

In vivo measurement of the acetylation state of sirtuin substrates as a proxy for sirtuin activity

31 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24582957

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.CELREP.2014.01.031

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28 July 2017

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28 July 2017

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