Targeting PTPs with small molecule inhibitors in cancer treatment (Q33554884)

28 July 2017

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title

Targeting PTPs with small molecule inhibitors in cancer treatment (English)

1 reference

28 July 2017

Zhong-Xing Jiang

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28 July 2017

Zhong-Yin Zhang

series ordinal

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28 July 2017

publication date

1 June 2008

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Cancer and Metastasis Reviews

28 July 2017

published in

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28 July 2017

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28 July 2017

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28 July 2017

page(s)

263-272

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PTP1B contributes to the oncogenic properties of colon cancer cells through Src activation

28 July 2017

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21 June 2018

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PRL-1 tyrosine phosphatase regulates c-Src levels, adherence, and invasion in human lung cancer cells

21 June 2018

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The role of Shp2 (PTPN11) in cancer.

21 June 2018

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PRL3 promotes cell invasion and proliferation by down-regulation of Csk leading to Src activation

21 June 2018

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21 June 2018

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Increased hypothalamic protein tyrosine phosphatase 1B contributes to leptin resistance with age

21 June 2018

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Potent benzimidazole sulfonamide protein tyrosine phosphatase 1B inhibitors containing the heterocyclic (S)-isothiazolidinone phosphotyrosine mimetic

21 June 2018

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Discovery of a novel shp2 protein tyrosine phosphatase inhibitor

21 June 2018

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Protein kinases and phosphatases as therapeutic targets in cancer.

21 June 2018

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Protein-tyrosine phosphatases and cancer

21 June 2018

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PRL tyrosine phosphatases regulate rho family GTPases to promote invasion and motility

21 June 2018

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Synthesis and biological evaluation of rhodanine derivatives as PRL-3 inhibitors

21 June 2018

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Protein tyrosine phosphatase PRL-3 in malignant cells and endothelial cells: expression and function

21 June 2018

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PRL phosphatases as potential molecular targets in cancer

21 June 2018

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Structure and biochemical properties of PRL-1, a phosphatase implicated in cell growth, differentiation, and tumor invasion

21 June 2018

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Genetic analysis of the kinome and phosphatome in cancer

21 June 2018

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The role of protein-tyrosine phosphatase 1B in integrin signaling

21 June 2018

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ERBB receptors and cancer: the complexity of targeted inhibitors

21 June 2018

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Dual specificity protein phosphatases: therapeutic targets for cancer and Alzheimer's disease

21 June 2018

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Activating mutations of the noonan syndrome-associated SHP2/PTPN11 gene in human solid tumors and adult acute myelogenous leukemia

21 June 2018

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Trimeric structure of PRL-1 phosphatase reveals an active enzyme conformation and regulation mechanisms

21 June 2018

1 reference

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High expression of PRL-3 promotes cancer cell motility and liver metastasis in human colorectal cancer: a predictive molecular marker of metachronous liver and lung metastases

21 June 2018

1 reference

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Oncogenic mechanisms of the Helicobacter pylori CagA protein

21 June 2018

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Imatinib as a paradigm of targeted therapies

21 June 2018

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Protein tyrosine phosphatases in the human genome

21 June 2018

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Mutational analysis of the tyrosine phosphatome in colorectal cancers

21 June 2018

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Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib

21 June 2018

1 reference

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The role of protein tyrosine phosphatase 1B in Ras signaling

21 June 2018

1 reference

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PRL-3 expression in metastatic cancers

21 June 2018

1 reference

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Enhanced cell cycle progression and down regulation of p21(Cip1/Waf1) by PRL tyrosine phosphatases

21 June 2018

1 reference

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Cellular effects of small molecule PTP1B inhibitors on insulin signaling

21 June 2018

1 reference

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Inhibition of Cdc25 phosphatases by indolyldihydroxyquinones

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797549

PRL-3 and PRL-1 promote cell migration, invasion, and metastasis

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797549

Crystal structure of PTP1B complexed with a potent and selective bidentate inhibitor

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797549

Pentamidine is an inhibitor of PRL phosphatases with anticancer activity

21 June 2018

1 reference

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Dual-specificity phosphatases as targets for antineoplastic agents

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797549

The tyrosine phosphatase PRL-1 localizes to the endoplasmic reticulum and the mitotic spindle and is required for normal mitosis

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797549

PTP1B antisense oligonucleotide lowers PTP1B protein, normalizes blood glucose, and improves insulin sensitivity in diabetic mice

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797549

Mutations in PTPN11, encoding the protein tyrosine phosphatase SHP-2, cause Noonan syndrome

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797549

Biology of HER2 and its importance in breast cancer

21 June 2018

1 reference

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A phosphatase associated with metastasis of colorectal cancer

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797549

Coscinosulfate, a CDC25 phosphatase inhibitor from the sponge Coscinoderma mathewsi

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797549

Acquisition of a specific and potent PTP1B inhibitor from a novel combinatorial library and screening procedure

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797549

Protein tyrosine phosphatases: prospects for therapeutics

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797549

Oncogenic kinase signalling

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797549

Role of PRL-3, a human muscle-specific tyrosine phosphatase, in angiotensin-II signaling

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797549

Attenuation of adhesion-dependent signaling and cell spreading in transformed fibroblasts lacking protein tyrosine phosphatase-1B.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797549

Identification of protein-tyrosine phosphatase 1B as the major tyrosine phosphatase activity capable of dephosphorylating and activating c-Src in several human breast cancer cell lines

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797549

Role of the Cdc25A phosphatase in human breast cancer

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797549

Increased energy expenditure, decreased adiposity, and tissue-specific insulin sensitivity in protein-tyrosine phosphatase 1B-deficient mice

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797549

Cell cycle regulation by the Cdc25 phosphatase family

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797549

Molecular mechanism for the Shp-2 tyrosine phosphatase function in promoting growth factor stimulation of Erk activity

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797549

Signaling--2000 and beyond

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797549

Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797549

The Croonian Lecture 1997. The phosphorylation of proteins on tyrosine: its role in cell growth and disease

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797549

Crystal structure of the tyrosine phosphatase SHP-2

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797549

Protein tyrosine phosphatase 1B interacts with and is tyrosine phosphorylated by the epidermal growth factor receptor

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797549

Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797549

PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797549

Development of "substrate-trapping" mutants to identify physiological substrates of protein tyrosine phosphatases

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797549

Prenylation of oncogenic human PTP(CAAX) protein tyrosine phosphatases

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797549

Multiple requirements for SHPTP2 in epidermal growth factor-mediated cell cycle progression

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797549

PRL-1, a unique nuclear protein tyrosine phosphatase, affects cell growth

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797549

Increased expression of specific protein tyrosine phosphatases in human breast epithelial cells neoplastically transformed by the neu oncogene.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797549

Role of SH-PTP2, a protein-tyrosine phosphatase with Src homology 2 domains, in insulin-stimulated Ras activation

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797549

The role of cdc25 in checkpoints and feedback controls in the eukaryotic cell cycle.

21 June 2018

1 reference

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21 June 2018

Cdc2 regulatory factors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797549

CDC25 phosphatases as potential human oncogenes

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797549

Cell transformation and activation of pp60c-src by overexpression of a protein tyrosine phosphatase

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797549

Structure-based design and discovery of protein tyrosine phosphatase inhibitors incorporating novel isothiazolidinone heterocyclic phosphotyrosine mimetics

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797549

Design, construction, and intracellular activation of an intramolecularly self-silenced signal transduction inhibitor

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797549

Structure-based design of protein tyrosine phosphatase-1B inhibitors.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797549

Somatic mutations in PTPN11 in juvenile myelomonocytic leukemia, myelodysplastic syndromes and acute myeloid leukemia

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797549

Identification of a potent and selective pharmacophore for Cdc25 dual specificity phosphatase inhibitors

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797549

Induction of mammary gland hyperplasia in transgenic mice over-expressing human Cdc25B.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797549

Targeted disruption of the tyrosine phosphatase PTPalpha leads to constitutive downregulation of the kinases Src and Fyn.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797549

Overexpression of the protein tyrosine phosphatase PTP1B in human breast cancer: association with p185c-erbB-2 protein expression

31 October 2018

1 reference

12 December 2020

Dnacin A1 and dnacin B1 are antitumor antibiotics that inhibit cdc25B phosphatase activity

1 reference

12 December 2020

The SH2-containing protein-tyrosine phosphatase SH-PTP2 is required upstream of MAP kinase for early Xenopus development

1 reference

12 December 2020

Increased susceptibility to carcinogen-induced mammary tumors in MMTV-Cdc25B transgenic mice

1 reference

12 December 2020

Tyrosine kinases as targets for cancer therapy

1 reference

12 December 2020

Biflavonoids inhibited phosphatase of regenerating liver-3 (PRL-3)

1 reference

12 December 2020

Isothiazolidinone heterocycles as inhibitors of protein tyrosine phosphatases: synthesis and structure-activity relationships of a peptide scaffold

1 reference

12 December 2020

Receptor protein tyrosine phosphatase alpha activates Src-family kinases and controls integrin-mediated responses in fibroblasts

1 reference

12 December 2020

Synthesis of a novel class of cdc25A inhibitors from vitamin D3

1 reference

12 December 2020

10.1007/S10555-008-9113-3

Identifiers

DOI

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28 July 2017

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28 July 2017

1 reference