Tipin-replication protein A interaction mediates Chk1 phosphorylation by ATR in response to genotoxic stress (Q33541382)

27 July 2017

title

Tipin-replication protein A interaction mediates Chk1 phosphorylation by ATR in response to genotoxic stress (English)

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27 July 2017

1 reference

1 reference

Aziz Sancar

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27 July 2017

Zafer Akan

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Michael G Kemp

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27 July 2017

Seçil Yilmaz

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27 July 2017

Mary Grillo

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27 July 2017

Stephanie L Smith-Roe

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27 July 2017

Tae-Hong Kang

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27 July 2017

Marila Cordeiro-Stone

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27 July 2017

William K Kaufmann

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27 July 2017

Robert T Abraham

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27 July 2017

Keziban Unsal-Kaçmaz

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27 July 2017

language of work or name

English

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publication date

15 March 2010

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Journal of Biological Chemistry

27 July 2017

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inferred from page(s)

published in

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27 July 2017

volume

285

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27 July 2017

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27 July 2017

page(s)

16562-16571

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Interactions of human mismatch repair proteins MutSalpha and MutLalpha with proteins of the ATR-Chk1 pathway

27 July 2017

cites work

1 reference

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An alternative form of replication protein a expressed in normal human tissues supports DNA repair

21 June 2018

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A naturally occurring human RPA subunit homolog does not support DNA replication or cell-cycle progression

21 June 2018

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Human RPA phosphorylation by ATR stimulates DNA synthesis and prevents ssDNA accumulation during DNA-replication stress

21 June 2018

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Reconstitution of human claspin-mediated phosphorylation of Chk1 by the ATR (ataxia telangiectasia-mutated and rad3-related) checkpoint kinase

21 June 2018

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Tim-Tipin dysfunction creates an indispensible reliance on the ATR-Chk1 pathway for continued DNA synthesis

21 June 2018

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The F box protein Fbx6 regulates Chk1 stability and cellular sensitivity to replication stress

21 June 2018

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Taking the time to make important decisions: the checkpoint effector kinases Chk1 and Chk2 and the DNA damage response

21 June 2018

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Human DNA damage response and repair deficiency syndromes: linking genomic instability and cell cycle checkpoint proficiency

21 June 2018

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Cooperative activation of the ATR checkpoint kinase by TopBP1 and damaged DNA.

21 June 2018

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An alternative form of replication protein a prevents viral replication in vitro

21 June 2018

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How shelterin protects mammalian telomeres

21 June 2018

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ATR: an essential regulator of genome integrity

21 June 2018

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G2 checkpoint abrogation and checkpoint kinase-1 targeting in the treatment of cancer

21 June 2018

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Profiling of UV-induced ATM/ATR signaling pathways.

21 June 2018

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Activation and regulation of ATM kinase activity in response to DNA double-strand breaks

21 June 2018

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Tipin is required for stalled replication forks to resume DNA replication after removal of aphidicolin in Xenopus egg extracts

21 June 2018

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Reconstitution of a human ATR-mediated checkpoint response to damaged DNA.

21 June 2018

1 reference

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The Rad9-Hus1-Rad1 (9-1-1) clamp activates checkpoint signaling via TopBP1.

21 June 2018

1 reference

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ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage

21 June 2018

1 reference

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Function of a conserved checkpoint recruitment domain in ATRIP proteins

21 June 2018

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The human Tim/Tipin complex coordinates an Intra-S checkpoint response to UV that slows replication fork displacement

21 June 2018

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Mammalian TIMELESS and Tipin are evolutionarily conserved replication fork-associated factors

21 June 2018

1 reference

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Tipin and Timeless form a mutually protective complex required for genotoxic stress resistance and checkpoint function

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2878033

Human Tim/Timeless-interacting protein, Tipin, is required for efficient progression of S phase and DNA replication checkpoint

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2878033

RPA2 is a direct downstream target for ATR to regulate the S-phase checkpoint

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2878033

A dynamic model for replication protein A (RPA) function in DNA processing pathways

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2878033

Claspin operates downstream of TopBP1 to direct ATR signaling towards Chk1 activation

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2878033

ATR kinase activation mediated by MutSalpha and MutLalpha in response to cytotoxic O6-methylguanine adducts

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2878033

Spatial organization of the mammalian genome surveillance machinery in response to DNA strand breaks

21 June 2018

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Site-specific phosphorylation of a checkpoint mediator protein controls its responses to different DNA structures

21 June 2018

1 reference

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TopBP1 activates the ATR-ATRIP complex

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2878033

Chk1 is required to maintain claspin stability

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2878033

Phosphorylation of Xenopus Rad1 and Hus1 defines a readout for ATR activation that is independent of Claspin and the Rad9 carboxy terminus

21 June 2018

1 reference

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Rapid PIKK-dependent release of Chk1 from chromatin promotes the DNA-damage checkpoint response.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2878033

Recruitment of DNA damage checkpoint proteins to damage in transcribed and nontranscribed sequences

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2878033

Genotoxic stress targets human Chk1 for degradation by the ubiquitin-proteasome pathway.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2878033

Coupling of human circadian and cell cycles by the timeless protein

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2878033

ATRIP binding to replication protein A-single-stranded DNA promotes ATR-ATRIP localization but is dispensable for Chk1 phosphorylation

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2878033

Interaction between human MCM7 and Rad17 proteins is required for replication checkpoint signaling

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2878033

Mcm2 is a direct substrate of ATM and ATR during DNA damage and DNA replication checkpoint responses

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2878033

Human claspin is a ring-shaped DNA-binding protein with high affinity to branched DNA structures

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2878033

Minichromosome maintenance proteins are direct targets of the ATM and ATR checkpoint kinases

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2878033

Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2878033

Human Claspin works with BRCA1 to both positively and negatively regulate cell proliferation

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2878033

Quaternary structure of ATR and effects of ATRIP and replication protein A on its DNA binding and kinase activities

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2878033

MSH2 and ATR form a signaling module and regulate two branches of the damage response to DNA methylation

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2878033

Tipin, a novel timeless-interacting protein, is developmentally co-expressed with timeless and disrupts its self-association

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2878033

Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2878033

Human claspin is required for replication checkpoint control

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2878033

Claspin, a Chk1-regulatory protein, monitors DNA replication on chromatin independently of RPA, ATR, and Rad17.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2878033

Preferential binding of ATR protein to UV-damaged DNA.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2878033

ATR and ATRIP: partners in checkpoint signaling

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2878033

ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2878033

Claspin, a novel protein required for the activation of Chk1 during a DNA replication checkpoint response in Xenopus egg extracts

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2878033

Structural basis for the recognition of DNA repair proteins UNG2, XPA, and RAD52 by replication factor RPA

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2878033

Chromatin association of human origin recognition complex, cdc6, and minichromosome maintenance proteins during the cell cycle: assembly of prereplication complexes in late mitosis

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2878033

Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2878033

REPLICATION PROTEIN A: A Heterotrimeric, Single-Stranded DNA-Binding Protein Required for Eukaryotic DNA Metabolism

21 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2878033

Recombinant replication protein A: expression, complex formation, and functional characterization

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2878033

Rpa4, a homolog of the 34-kilodalton subunit of the replication protein A complex

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2878033

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

21 June 2018

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Cellular factors required for multiple stages of SV40 DNA replication in vitro

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2878033

The role of single-stranded DNA and polymerase alpha in establishing the ATR, Hus1 DNA replication checkpoint

21 June 2018

1 reference

Crossref

https://api.crossref.org/works/10.1074%2FJBC.M110.110304

Essential role of BETA2/NeuroD1 in development of the vestibular and auditory systems

21 January 2018

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Crossref

https://api.crossref.org/works/10.1074%2FJBC.M110.110304

Replisome progression complex links DNA replication to sister chromatid cohesion in Xenopus egg extracts.

21 January 2018

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Crossref

https://api.crossref.org/works/10.1074%2FJBC.M110.110304

21 January 2018

Identifiers

DOI

10.1074/JBC.M110.110304

1 reference

27 July 2017

1 reference

27 July 2017

1 reference