A possibility of nutriceuticals as an anti-aging intervention: activation of sirtuins by promoting mammalian NAD biosynthesis (Q33525208)

27 July 2017

1 reference

title

A possibility of nutriceuticals as an anti-aging intervention: activation of sirtuins by promoting mammalian NAD biosynthesis (English)

1 reference

27 July 2017

Shin-Ichiro Imai

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27 July 2017

publication date

18 January 2010

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27 July 2017

published in

Pharmacological Research

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27 July 2017

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27 July 2017

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27 July 2017

page(s)

42-47

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Nicotinamide phosphoribosyltransferase (NAMPT/PBEF/visfatin) is constitutively released from human hepatocytes

27 July 2017

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Assimilation of endogenous nicotinamide riboside is essential for calorie restriction-mediated life span extension in Saccharomyces cerevisiae

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Circadian clock feedback cycle through NAMPT-mediated NAD+ biosynthesis

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Circadian control of the NAD+ salvage pathway by CLOCK-SIRT1

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21 June 2018

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Glucose restriction inhibits skeletal myoblast differentiation by activating SIRT1 through AMPK-mediated regulation of Nampt

21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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Nampt/PBEF/Visfatin regulates insulin secretion in beta cells as a systemic NAD biosynthetic enzyme

21 June 2018

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A therapeutic role for sirtuins in diseases of aging?

21 June 2018

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Nutrient-sensitive mitochondrial NAD+ levels dictate cell survival

21 June 2018

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21 June 2018

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Nicotinamide riboside promotes Sir2 silencing and extends lifespan via Nrk and Urh1/Pnp1/Meu1 pathways to NAD+.

21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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Sirt1 regulates insulin secretion by repressing UCP2 in pancreatic beta cells

21 June 2018

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Poly(ADP-ribose) polymerase-1-dependent cardiac myocyte cell death during heart failure is mediated by NAD+ depletion and reduced Sir2alpha deacetylase activity

21 June 2018

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21 June 2018

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Mechanism of human SIRT1 activation by resveratrol

21 June 2018

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Substrate-specific activation of sirtuins by resveratrol

21 June 2018

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21 June 2018

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Sir2 mediates longevity in the fly through a pathway related to calorie restriction

21 June 2018

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The NAD biosynthesis pathway mediated by nicotinamide phosphoribosyltransferase regulates Sir2 activity in mammalian cells

21 June 2018

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Sirtuin activators mimic caloric restriction and delay ageing in metazoans

21 June 2018

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The Sir2 family of protein deacetylases

21 June 2018

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The action of extracellular NAD+ on Ca2+ efflux, hemodynamics and some metabolic parameters in the isolated perfused rat liver

21 June 2018

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Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan

21 June 2018

1 reference

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Complete genome sequence of the broad-host-range vibriophage KVP40: comparative genomics of a T4-related bacteriophage

21 June 2018

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Mechanisms of the age-associated deterioration in glucose tolerance: contribution of alterations in insulin secretion, action, and clearance

21 June 2018

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Reconstructing eukaryotic NAD metabolism

21 June 2018

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Nicotinamide and PNC1 govern lifespan extension by calorie restriction in Saccharomyces cerevisiae

21 June 2018

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The Drosophila melanogaster sir2+ gene is nonessential and has only minor effects on position-effect variegation.

21 June 2018

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Nicotinamide adenine dinucleotide, a metabolic regulator of transcription, longevity and disease

21 June 2018

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Linking chromatin function with metabolic networks: Sir2 family of NAD(+)-dependent deacetylases

21 June 2018

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Calorie restriction extends Saccharomyces cerevisiae lifespan by increasing respiration

21 June 2018

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Telomeric and rDNA silencing in Saccharomyces cerevisiae are dependent on a nuclear NAD(+) salvage pathway.

21 June 2018

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Manipulation of a nuclear NAD+ salvage pathway delays aging without altering steady-state NAD+ levels

21 June 2018

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21 June 2018

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Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans

21 June 2018

1 reference

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Identification of a plasmid-encoded gene from Haemophilus ducreyi which confers NAD independence

21 June 2018

1 reference

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Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae

21 June 2018

1 reference

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Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins

21 June 2018

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A phylogenetically conserved NAD+-dependent protein deacetylase activity in the Sir2 protein family.

21 June 2018

1 reference

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The silencing protein SIR2 and its homologs are NAD-dependent protein deacetylases

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2873125

Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2873125

The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2873125

Enzymology of NAD+ synthesis

21 June 2018

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Independent influence of age on basal insulin secretion in nondiabetic humans. European Group for the Study of Insulin Resistance

21 June 2018

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Understanding the cardiovascular actions of soy isoflavones: potential novel targets for antihypertensive drug development

21 June 2018

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Specific SIRT1 activation mimics low energy levels and protects against diet-induced metabolic disorders by enhancing fat oxidation

31 October 2018

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Pellagra: A clue as to why energy failure causes diseases?

31 October 2018

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Overlapping and distinct functions for a Caenorhabditis elegans SIR2 and DAF-16/FOXO.

31 October 2018

1 reference

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Increased dosage of mammalian Sir2 in pancreatic beta cells enhances glucose-stimulated insulin secretion in mice

31 October 2018

1 reference

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Decrease in glucose-stimulated insulin secretion with aging is independent of insulin action.

31 October 2018

1 reference

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Enzymatic synthesis of nicotinamide mononucleotide.

31 October 2018

1 reference

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SIRT1 markedly extends replicative lifespan if the NAD+ salvage pathway is enhanced

31 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20085812

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Extension of human cell lifespan by nicotinamide phosphoribosyltransferase

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20085812

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

'Anti-aging' medicine: does it exist? A critical discussion of 'anti-aging health products'

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20085812

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.PHRS.2010.01.006

1 reference

27 July 2017

1 reference

27 July 2017

1 reference