Detection of ligand binding hot spots on protein surfaces via fragment-based methods: application to DJ-1 and glucocerebrosidase (Q33466833)

27 July 2017

title

Detection of ligand binding hot spots on protein surfaces via fragment-based methods: application to DJ-1 and glucocerebrosidase (English)

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27 July 2017

1 reference

Jose M M Caaveiro

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27 July 2017

Dima Kozakov

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Gregory A Petsko

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27 July 2017

Dagmar Ringe

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27 July 2017

Raquel L Lieberman

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27 July 2017

Melissa R Landon

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27 July 2017

Quyen Q Hoang

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27 July 2017

Shulin Ju

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27 July 2017

Susan D Orwig

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27 July 2017

Ryan Brenke

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27 July 2017

Gwo-Yu Chuang

1 reference

27 July 2017

Dmitry Beglov

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27 July 2017

Sandor Vajda

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27 July 2017

language of work or name

1 reference

12 June 2009

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Journal of Computer - Aided Molecular Design

27 July 2017

published in

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27 July 2017

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27 July 2017

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27 July 2017

page(s)

491-500

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Ligand efficiency and fragment-based drug discovery

27 July 2017

cites work

1 reference

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Genes associated with Parkinson syndrome

21 June 2018

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Acid beta-glucosidase: insights from structural analysis and relevance to Gaucher disease therapy

21 June 2018

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21 June 2018

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Novel druggable hot spots in avian influenza neuraminidase H5N1 revealed by computational solvent mapping of a reduced and representative receptor ensemble.

21 June 2018

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21 June 2018

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DJ-1: a newcomer in Parkinson's disease pathology

21 June 2018

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LIMP-2 is a receptor for lysosomal mannose-6-phosphate-independent targeting of beta-glucocerebrosidase

21 June 2018

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21 June 2018

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Structure of acid beta-glucosidase with pharmacological chaperone provides insight into Gaucher disease

21 June 2018

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The iminosugar isofagomine increases the activity of N370S mutant acid beta-glucosidase in Gaucher fibroblasts by several mechanisms

21 June 2018

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Probing hot spots at protein-ligand binding sites: a fragment-based approach using biophysical methods

21 June 2018

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Therapeutic strategies to ameliorate lysosomal storage disorders--a focus on Gaucher disease

21 June 2018

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Impaired trafficking of mutants of lysosomal glucocerebrosidase in Gaucher's disease.

21 June 2018

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The N370S (Asn370-->Ser) mutation affects the capacity of glucosylceramidase to interact with anionic phospholipid-containing membranes and saposin C

21 June 2018

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Solution structure of human saposin C in a detergent environment

21 June 2018

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21 June 2018

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Refinement of macromolecular structures by the maximum-likelihood method

21 June 2018

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The CCP4 suite: programs for protein crystallography

21 June 2018

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A missense mutation (L166P) in DJ-1, linked to familial Parkinson's disease, confers reduced protein stability and impairs homo-oligomerization.

21 June 2018

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Solution structure of human saposin C: pH-dependent interaction with phospholipid vesicles

21 June 2018

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The 1.1-A resolution crystal structure of DJ-1, the protein mutated in autosomal recessive early onset Parkinson's disease

21 June 2018

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L166P mutant DJ-1, causative for recessive Parkinson's disease, is degraded through the ubiquitin-proteasome system

21 June 2018

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Chemical chaperones increase the cellular activity of N370S beta -glucosidase: a therapeutic strategy for Gaucher disease

21 June 2018

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Computational mapping identifies the binding sites of organic solvents on proteins

21 June 2018

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Locating and characterizing binding sites on proteins

21 June 2018

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Analysis of human acid beta-glucosidase by site-directed mutagenesis and heterologous expression.

21 June 2018

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Processing of X-ray diffraction data collected in oscillation mode

21 June 2018

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Identification of hot spots within druggable binding regions by computational solvent mapping of proteins

21 January 2018

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Chemical chaperones and permissive temperatures alter localization of Gaucher disease associated glucocerebrosidase variants

31 October 2018

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31 October 2018

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Multiple solvent crystal structures: probing binding sites, plasticity and hydration

31 October 2018

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Gaucher disease-associated glucocerebrosidases show mutation-dependent chemical chaperoning profiles

31 October 2018

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Analyses of variant acid beta-glucosidases: effects of Gaucher disease mutations

31 October 2018

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31 October 2018

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31 October 2018

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Structural comparison of differently glycosylated forms of acid-β-glucosidase, the defective enzyme in Gaucher disease

31 October 2018

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Novel statistical-thermodynamic methods to predict protein-ligand binding positions using probability distribution functions

31 October 2018

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12 December 2020

Characterization of human saposins by NMR spectroscopy

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12 December 2020

Design and synthesis of highly potent and selective pharmacological chaperones for the treatment of Gaucher's disease

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Genetics of parkinsonism

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Identifiers

DOI

1 reference

journals/jcamd/LandonLHJCOKBCBVPR09

27 July 2017

DBLP publication ID

1 reference

DBLP Dataset 2021-01-02

28 January 2021

1 reference

27 July 2017

1 reference