Smoothened adopts multiple active and inactive conformations capable of trafficking to the primary cilium (Q33429986)

26 July 2017

title

Smoothened adopts multiple active and inactive conformations capable of trafficking to the primary cilium (English)

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26 July 2017

Miao-Hsueh Chen

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Christopher W Wilson

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26 July 2017

Pao-Tien Chuang

series ordinal

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26 July 2017

language of work or name

English

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publication date

13 April 2009

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26 July 2017

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26 July 2017

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26 July 2017

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26 July 2017

page(s)

e5182

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Creative Commons Attribution 4.0 International

26 July 2017

start time

13 April 2009

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April 2022 Public Data File from Crossref

copyrighted

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cites work

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Phosphorylation of Gli2 by protein kinase A is required for Gli2 processing and degradation and the Sonic Hedgehog-regulated mouse development

14 July 2018

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G protein Galphai functions immediately downstream of Smoothened in Hedgehog signalling

14 July 2018

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The decoupling of Smoothened from Galphai proteins has little effect on Gli3 protein processing and Hedgehog-regulated chick neural tube patterning

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Beta-arrestin-mediated localization of smoothened to the primary cilium

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Intraflagellar transport, cilia, and mammalian Hedgehog signaling: analysis in mouse embryonic fibroblasts

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Hedgehog regulates smoothened activity by inducing a conformational switch

14 July 2018

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Patched1 regulates hedgehog signaling at the primary cilium

14 July 2018

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Cilia and developmental signaling

14 July 2018

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The hedgehog regulated oncogenes Gli1 and Gli2 block myoblast differentiation by inhibiting MyoD-mediated transcriptional activation

14 July 2018

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Repression of smoothened by patched-dependent (pro-)vitamin D3 secretion

14 July 2018

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Activation of heterotrimeric G proteins by Smoothened

14 July 2018

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Oxysterols stimulate Sonic hedgehog signal transduction and proliferation of medulloblastoma cells

14 July 2018

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Divergence of hedgehog signal transduction mechanism between Drosophila and mammals

14 July 2018

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Purmorphamine activates the Hedgehog pathway by targeting Smoothened.

14 July 2018

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Signaling from Smo to Ci/Gli: conservation and divergence of Hedgehog pathways from Drosophila to vertebrates

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An incredible decade for the primary cilium: a look at a once-forgotten organelle

14 July 2018

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Gli2 and Gli3 localize to cilia and require the intraflagellar transport protein polaris for processing and function

14 July 2018

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Vertebrate Smoothened functions at the primary cilium

14 July 2018

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Cilia and Hedgehog responsiveness in the mouse

14 July 2018

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Mouse intraflagellar transport proteins regulate both the activator and repressor functions of Gli transcription factors

14 July 2018

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Palmitoylation is required for the production of a soluble multimeric Hedgehog protein complex and long-range signaling in vertebrates

14 July 2018

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Hedgehog signalling in the mouse requires intraflagellar transport proteins

14 July 2018

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Altered localization of Drosophila Smoothened protein activates Hedgehog signal transduction

14 July 2018

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Developmental roles and clinical significance of hedgehog signaling

14 July 2018

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14 July 2018

Intraflagellar transport

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2664476

Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened

14 July 2018

1 reference

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Small molecule modulation of Smoothened activity

14 July 2018

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Patched acts catalytically to suppress the activity of Smoothened

14 July 2018

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Hedgehog-regulated processing of Gli3 produces an anterior/posterior repressor gradient in the developing vertebrate limb

14 July 2018

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A binding site for Gli proteins is essential for HNF-3beta floor plate enhancer activity in transgenics and can respond to Shh in vitro

14 July 2018

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Pertussis toxin substrate, the putative Ni component of adenylyl cyclases, is an alpha beta heterodimer regulated by guanine nucleotide and magnesium

14 July 2018

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14 July 2018

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A recombinant murine retrovirus for simian virus 40 large T cDNA transforms mouse fibroblasts to anchorage-independent growth

14 July 2018

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14 July 2018

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Negative regulation of Hedgehog signaling by the cholesterogenic enzyme 7-dehydrocholesterol reductase

14 July 2018

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https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0005182

Localization of Inv in a distinctive intraciliary compartment requires the C-terminal ninein-homolog-containing region.

21 January 2018

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Protein kinase A is a common negative regulator of Hedgehog signaling in the vertebrate embryo

21 January 2018

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https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0005182

Long-range sclerotome induction by sonic hedgehog: direct role of the amino-terminal cleavage product and modulation by the cyclic AMP signaling pathway

21 January 2018

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https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0005182

Antagonizing cAMP-dependent protein kinase A in the dorsal CNS activates a conserved Sonic hedgehog signaling pathway.

21 January 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2664476

10.1371/JOURNAL.PONE.0005182

31 October 2018

Identifiers

DOI

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26 July 2017

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26 July 2017

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