Phase I dosage finding and pharmacokinetic study of intravenous topotecan and oral erlotinib in adults with refractory solid tumors (Q33412801)

26 July 2017

title

Phase I dosage finding and pharmacokinetic study of intravenous topotecan and oral erlotinib in adults with refractory solid tumors (English)

1 reference

26 July 2017

1 reference

1 reference

Clinton F Stewart

1 reference

26 July 2017

Michael Tagen

1 reference

26 July 2017

Lee S Schwartzberg

1 reference

26 July 2017

L Johnetta Blakely

1 reference

26 July 2017

Kurt W Tauer

1 reference

26 July 2017

Linda M Smiley

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26 July 2017

publication date

22 January 2014

1 reference

Cancer Chemotherapy and Pharmacology

26 July 2017

published in

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26 July 2017

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26 July 2017

1 reference

26 July 2017

page(s)

561-568

1 reference

Expected benefits of topotecan combined with lapatinib in recurrent ovarian cancer according to biological profile: a phase 2 trial

26 July 2017

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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Erlotinib (Tarceva, OSI-774) antagonizes ATP-binding cassette subfamily B member 1 and ATP-binding cassette subfamily G member 2-mediated drug resistance

21 June 2018

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Involvement of rat and human organic anion transporter 3 in the renal tubular secretion of topotecan [(S)-9-dimethylaminomethyl-10-hydroxy-camptothecin hydrochloride].

21 June 2018

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21 June 2018

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21 June 2018

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Topotecan is a substrate for multidrug resistance associated protein 4.

21 June 2018

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21 June 2018

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Functionally defective or altered CYP3A4 and CYP3A5 single nucleotide polymorphisms and their detection with genotyping tests

21 June 2018

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Multicenter phase II study of erlotinib, an oral epidermal growth factor receptor tyrosine kinase inhibitor, in patients with recurrent or metastatic squamous cell cancer of the head and neck

21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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An overview of the clinical pharmacology of topotecan

21 June 2018

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21 June 2018

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Increased oral bioavailability of topotecan in combination with the breast cancer resistance protein and P-glycoprotein inhibitor GF120918.

21 June 2018

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Efficacy and safety of erlotinib HCl, an epidermal growth factor receptor (HER1/EGFR) tyrosine kinase inhibitor, in patients with advanced ovarian carcinoma: results from a phase II multicenter study

21 January 2018

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Efficacy and safety of erlotinib in patients with locally advanced or metastatic breast cancer

21 January 2018

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The MDR1 polymorphisms at exons 21 and 26 predict steroid weaning in pediatric heart transplant patients

21 January 2018

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21 January 2018

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21 January 2018

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Development and validation of limited sampling models for topotecan lactone pharmacokinetic studies in children

21 January 2018

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Population pharmacokinetic and adverse event analysis of topotecan in patients with solid tumors.

21 January 2018

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The CYP3A4*1B variant is related to the onset of puberty, a known risk factor for the development of breast cancer

21 January 2018

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Clinical pharmacodynamics of continuous infusion topotecan in children: systemic exposure predicts hematologic toxicity

31 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24448640

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Epidermal growth factor receptor-targeted therapy for pancreatic cancer

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24448640

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1007/S00280-014-2385-0

1 reference

Dimensions Publication ID

26 July 2017

0 references

1 reference

26 July 2017

1 reference