Advances in megakaryocytopoiesis and thrombopoiesis: from bench to bedside. (Q33407110)

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28 February 2020

title

Advances in megakaryocytopoiesis and thrombopoiesis: from bench to bedside (English)

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28 February 2020

Varda R Deutsch

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28 February 2020

language of work or name

English

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publication date

18 April 2013

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British Journal of Haematology

28 February 2020

published in

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volume

161

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28 February 2020

issue

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page(s)

778-793

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Eltrombopag before procedures in patients with cirrhosis and thrombocytopenia

28 February 2020

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Blood platelets are assembled principally at the ends of proplatelet processes produced by differentiated megakaryocytes

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Megakaryocytes possess a functional intrinsic apoptosis pathway that must be restrained to survive and produce platelets

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Tensin2 is a novel mediator in thrombopoietin (TPO)-induced cellular proliferation by promoting Akt signaling

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Safety and efficacy of romiplostim in patients with lower-risk myelodysplastic syndrome and thrombocytopenia

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Phase 2 study of romiplostim in patients with low- or intermediate-risk myelodysplastic syndrome receiving azacitidine therapy

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Native thrombopoietin: structure and function.

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The molecular mechanisms that control thrombopoiesis

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Thrombopoietin and the hematopoietic stem cell

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Lineage-specific hematopoietic growth factors

21 January 2018

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NMR structural studies of interactions of a small, nonpeptidyl Tpo mimic with the thrombopoietin receptor extracellular juxtamembrane and transmembrane domains.

21 January 2018

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Calcium- and integrin-binding protein 1 regulates megakaryocyte ploidy, adhesion, and migration

21 January 2018

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Hierarchical differentiation of myeloid progenitors is encoded in the transcription factor network

21 January 2018

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Coordinate loss of a microRNA and protein-coding gene cooperate in the pathogenesis of 5q− syndrome

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Thrombopoietic factors in chronic bone marrow failure states: the platelet problem revisited

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Thrombopoietin therapy increases platelet yields in healthy platelet donors

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Efficacy of romiplostim in patients with chronic immune thrombocytopenic purpura: a double-blind randomised controlled trial

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Evaluation of bone marrow reticulin formation in chronic immune thrombocytopenia patients treated with romiplostim

21 January 2018

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Romiplostim or Standard of Care in Patients with Immune Thrombocytopenia

21 January 2018

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Contemporary management of primary immune thrombocytopenia in adults

21 January 2018

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Cloning and expression of murine thrombopoietin cDNA and stimulation of platelet production in vivo

21 January 2018

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RUNX1-induced silencing of non-muscle myosin heavy chain IIB contributes to megakaryocyte polyploidization

21 January 2018

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MicroRNA-mediated control of cell fate in megakaryocyte-erythrocyte progenitors

21 January 2018

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Biology and clinical management of myeloproliferative neoplasms and development of the JAK inhibitor ruxolitinib

21 January 2018

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A preliminary investigation into the action of anagrelide: thrombopoietin-c-Mpl receptor interactions

21 January 2018

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Eltrombopag for thrombocytopenia in patients with cirrhosis associated with hepatitis C.

21 January 2018

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Suppression of in vitro megakaryocyte production by antiplatelet autoantibodies from adult patients with chronic ITP

21 January 2018

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Embryonic origin of the adult hematopoietic system: advances and questions.

21 January 2018

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Anomalous megakaryocytopoiesis in mice with mutations in the c-Myb gene

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Mpl Baltimore: a thrombopoietin receptor polymorphism associated with thrombocytosis

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Heterogeneity and hierarchy within the most primitive hematopoietic stem cell compartment.

21 January 2018

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Preoperative use of romiplostim in thrombocytopenic patients with chronic hepatitis C and liver cirrhosis

21 January 2018

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21 January 2018

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21 January 2018

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Dynamic regulation of PU.1 expression in multipotent hematopoietic progenitors

21 January 2018

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Eltrombopag and improved hematopoiesis in refractory aplastic anemia

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TPO, but not soluble-IL-6 receptor, levels increase after anagrelide treatment of thrombocythemia in chronic myeloproliferative disorders

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Thrombopoietin/MPL participates in initiating and maintaining RUNX1-ETO acute myeloid leukemia via PI3K/AKT signaling

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Megakaryocyte and platelet production from human cord blood stem cells

21 January 2018

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Safety and efficacy of eltrombopag for treatment of chronic immune thrombocytopenia: results of the long-term, open-label EXTEND study

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21 January 2018

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21 January 2018

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Human plasma thrombopoietin levels are regulated by binding to platelet thrombopoietin receptors in vivo

21 January 2018

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21 January 2018

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Infectious causes of chronic immune thrombocytopenia

21 January 2018

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21 January 2018

Thrombopoietic agents

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Congenital amegakaryocytic thrombocytopenia-3 novel c-MPL mutations and their phenotypic correlations

21 January 2018

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Genetic analysis of hierarchical regulation for Gata1 and NF-E2 p45 gene expression in megakaryopoiesis

21 January 2018

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21 January 2018

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21 January 2018

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Hereditary thrombocytosis caused by MPLSer505Asn is associated with a high thrombotic risk, splenomegaly and progression to bone marrow fibrosis

21 January 2018

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Effects of anagrelide on in vivo megakaryocyte proliferation and maturation in essential thrombocythemia.

21 January 2018

1 reference

Human marrow megakaryocyte differentiation: multiparameter correlative analysis identifies von Willebrand factor as a sensitive and distinctive marker for early (2N and 4N) megakaryocytes.

21 January 2018

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Measurements of in vivo megakaryocytopoiesis: studies in nonhuman primates and patients

21 January 2018

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Management of chemotherapy-induced thrombocytopenia: current status of thrombopoietic agents

21 January 2018

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Exome sequencing identifies MPL as a causative gene in familial aplastic anemia

21 January 2018

1 reference

Apoptotic processes in megakaryocytes and platelets

21 January 2018

1 reference

Caspase-9 mediates the apoptotic death of megakaryocytes and platelets, but is dispensable for their generation and function

21 January 2018

1 reference

An activating splice donor mutation in the thrombopoietin gene causes hereditary thrombocythaemia

21 January 2018

1 reference

Effect of the nonpeptide thrombopoietin receptor agonist Eltrombopag on bone marrow cells from patients with acute myeloid leukemia and myelodysplastic syndrome

21 January 2018

1 reference

Thrombopoietin/MPL signaling regulates hematopoietic stem cell quiescence and interaction with the osteoblastic niche.

21 January 2018

1 reference

Risk of pulmonary embolism in patients with autoimmune disorders: a nationwide follow-up study from Sweden

21 January 2018

1 reference

Dynamic Visualization of Thrombopoiesis Within Bone Marrow

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.1111/BJH.12328

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23594368%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23594368%20AND%20SRC:MED&resulttype=core&format=json