Aggresome-forming TTRAP mediates pro-apoptotic properties of Parkinson's disease-associated DJ-1 missense mutations. (Q33385971)

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17 January 2020

title

Aggresome-forming TTRAP mediates pro-apoptotic properties of Parkinson's disease-associated DJ-1 missense mutations (English)

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17 January 2020

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17 January 2020

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17 January 2020

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17 January 2020

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17 January 2020

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17 January 2020

S Vilotti

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17 January 2020

R Calligaris

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17 January 2020

Z S Lavina

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17 January 2020

R Foti

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17 January 2020

L De Maso

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17 January 2020

M Pinto

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17 January 2020

M Gorza

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17 January 2020

C Casseler

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17 January 2020

S Gustincich

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17 January 2020

publication date

21 November 2008

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Cell Death & Differentiation

17 January 2020

published in

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volume

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issue

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17 January 2020

page(s)

428-438

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17 January 2020

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https://api.crossref.org/works/10.1038%2FCDD.2008.169

Ubiquitin-proteasome system and Parkinson's diseases

21 January 2018

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Altered proteasomal function in sporadic Parkinson's disease

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Parkin protects against the toxicity associated with mutant alpha-synuclein: proteasome dysfunction selectively affects catecholaminergic neurons

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Dopaminergic neurons in rat ventral midbrain cultures undergo selective apoptosis and form inclusions, but do not up-regulate iHSP70, following proteasomal inhibition

21 January 2018

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Parkin is recruited into aggresomes in a stress-specific manner: over-expression of parkin reduces aggresome formation but can be dissociated from parkin's effect on neuronal survival

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UCH-L1 aggresome formation in response to proteasome impairment indicates a role in inclusion formation in Parkinson's disease

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Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism

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DJ-1 gene deletion reveals that DJ-1 is an atypical peroxiredoxin-like peroxidase

21 January 2018

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The 1.1-A resolution crystal structure of DJ-1, the protein mutated in autosomal recessive early onset Parkinson's disease

21 January 2018

1 reference

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The Parkinson's disease-associated DJ-1 protein is a transcriptional co-activator that protects against neuronal apoptosis

21 January 2018

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DJ-1 is a redox-dependent molecular chaperone that inhibits alpha-synuclein aggregate formation

21 January 2018

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Down regulation of DJ-1 enhances cell death by oxidative stress, ER stress, and proteasome inhibition

21 January 2018

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Linking DJ-1 to neurodegeneration offers novel insights for understanding the pathogenesis of Parkinson's disease

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Nigrostriatal dopaminergic deficits and hypokinesia caused by inactivation of the familial Parkinsonism-linked gene DJ-1

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Hypersensitivity of DJ-1-deficient mice to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrindine (MPTP) and oxidative stress.

21 January 2018

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Drosophila DJ-1 mutants are selectively sensitive to environmental toxins associated with Parkinson's disease

21 January 2018

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On the oligomeric state of DJ-1 protein and its mutants associated with Parkinson Disease. A combined computational and in vitro study.

21 January 2018

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Structural Impact of Three Parkinsonism-Associated Missense Mutations on Human DJ-1 † , ‡

21 January 2018

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The DJ-1L166P mutant protein associated with early onset Parkinson's disease is unstable and forms higher-order protein complexes

21 January 2018

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Dimerization of Parkinson's disease-causing DJ-1 and formation of high molecular weight complexes in human brain

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Association of DJ-1 and parkin mediated by pathogenic DJ-1 mutations and oxidative stress

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TTRAP, a novel protein that associates with CD40, tumor necrosis factor (TNF) receptor-75 and TNF receptor-associated factors (TRAFs), and that inhibits nuclear factor-kappa B activation

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EAPII interacts with ETS1 and modulates its transcriptional function

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The conserved protein DCN-1/Dcn1p is required for cullin neddylation in C. elegans and S. cerevisiae

21 January 2018

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Sequence analysis identifies TTRAP, a protein that associates with CD40 and TNF receptor-associated factors, as a member of a superfamily of divalent cation-dependent phosphodiesterases

21 January 2018

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Aggresomes formed by alpha-synuclein and synphilin-1 are cytoprotective

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Interaction of DJ-1 with Daxx inhibits apoptosis signal-regulating kinase 1 activity and cell death

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Expression profiles of genes in DJ-1-knockdown and L 166 P DJ-1 mutant cells

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Active, phosphorylation-dependent mitogen-activated protein kinase (MAPK/ERK), stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK), and p38 kinase expression in Parkinson's disease and Dementia with Lewy bodies.

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Stress-induced alterations in parkin solubility promote parkin aggregation and compromise parkin's protective function

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The deacetylase HDAC6 regulates aggresome formation and cell viability in response to misfolded protein stress

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Parkin-mediated K63-linked polyubiquitination targets misfolded DJ-1 to aggresomes via binding to HDAC6

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7 January 2021

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Non-activated p53 co-localizes with sites of transcription within both the nucleoplasm and the nucleolus

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