A role for polyploidy in the tumorigenicity of Pim-1-expressing human prostate and mammary epithelial cells (Q33348538)

26 July 2017

title

A role for polyploidy in the tumorigenicity of Pim-1-expressing human prostate and mammary epithelial cells (English)

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26 July 2017

1 reference

Simon W Hayward

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Meejeon Roh

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26 July 2017

Omar E Franco

series ordinal

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26 July 2017

Riet van der Meer

series ordinal

1 reference

26 July 2017

Sarki A Abdulkadir

series ordinal

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26 July 2017

language of work or name

English

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publication date

2 July 2008

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26 July 2017

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26 July 2017

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26 July 2017

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26 July 2017

page(s)

e2572

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Creative Commons Attribution 4.0 International

26 July 2017

start time

2 July 2008

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April 2022 Public Data File from Crossref

copyrighted

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cites work

Limiting the proliferation of polyploid cells

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28 July 2018

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Cytokinesis failure generating tetraploids promotes tumorigenesis in p53-null cells

28 July 2018

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Chromosomal instability induced by Pim-1 is passage-dependent and associated with dysregulation of cyclin B1.

28 July 2018

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Cell cycle progression after cleavage failure: mammalian somatic cells do not possess a "tetraploidy checkpoint".

28 July 2018

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Overexpression of the oncogenic kinase Pim-1 leads to genomic instability.

28 July 2018

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Centrosomes, genomic instability, and cervical carcinogenesis

28 July 2018

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Delineation of prognostic biomarkers in prostate cancer

28 July 2018

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Human breast cancer cells generated by oncogenic transformation of primary mammary epithelial cells.

28 July 2018

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28 July 2018

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28 July 2018

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28 July 2018

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The PIM-1 serine kinase prolongs survival and inhibits apoptosis-related mitochondrial dysfunction in part through a bcl-2-dependent pathway

28 July 2018

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28 July 2018

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Expression of Bcl-xL and loss of p53 can cooperate to overcome a cell cycle checkpoint induced by mitotic spindle damage

28 July 2018

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28 July 2018

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28 July 2018

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Ploidy level determinations in high-grade and low-grade malignant variants of prostatic carcinoma

28 July 2018

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28 July 2018

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Tetraploidy and chromosomal instability are early events during cervical carcinogenesis

21 January 2018

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Chromosomal aneuploidy precedes morphological changes and supports multifocality in head and neck lesions.

21 January 2018

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21 January 2018

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Aneuploidy acts both oncogenically and as a tumor suppressor

21 January 2018

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Pim-1 expression in prostatic intraepithelial neoplasia and human prostate cancer

21 January 2018

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The serine/threonine kinase Pim-1

21 January 2018

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Significance of abnormal diploid DNA histograms in localized prostate cancer and adjacent benign prostatic tissue

21 January 2018

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c-Myc overexpression uncouples DNA replication from mitosis

21 January 2018

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Loss of APC induces polyploidy as a result of a combination of defects in mitosis and apoptosis

21 January 2018

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APC mutations lead to cytokinetic failures in vitro and tetraploid genotypes in Min mice

21 January 2018

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Suppression of polyploidy by the BRCA2 protein.

21 January 2018

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Overexpression of aurora kinase A in mouse mammary epithelium induces genetic instability preceding mammary tumor formation.

21 January 2018

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Tetraploid state induces p53-dependent arrest of nontransformed mammalian cells in G1.

21 January 2018

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Apoptosis regulation in tetraploid cancer cells

21 January 2018

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https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0002572

Pim-1 kinase promotes inactivation of the pro-apoptotic Bad protein by phosphorylating it on the Ser112 gatekeeper site

21 January 2018

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https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0002572

Haploinsufficient prostate tumor suppression by Nkx3.1: a role for chromatin accessibility in dosage-sensitive gene regulation.

21 January 2018

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https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0002572

Genetic disruption of cytosine DNA methyltransferase enzymes induces chromosomal instability in human cancer cells

21 January 2018

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https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0002572

Pim-1 induced polyploidy but did not affect megakaryocytic differentiation of K562 cells and CD34+ cells from cord blood

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2440349

Activated oncogenes promote and cooperate with chromosomal instability for neoplastic transformation

31 October 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2440349

Multistep carcinogenesis: a chain reaction of aneuploidizations

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2440349

C-myc overexpression and p53 loss cooperate to promote genomic instability

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2440349

HPV-18 E6 inhibits p53 DNA binding activity regardless of the oligomeric state of p53 or the exact p53 recognition sequence.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2440349

Debate surges over the origins of genomic defects in cancer

31 October 2018

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12 December 2020

Does aneuploidy or mutation start cancer?

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12 December 2020

Centrosome abnormalities and chromosome instability occur together in pre-invasive carcinomas

1 reference

12 December 2020

Analysis of chromosome aneuploidy in breast carcinoma progression by using fluorescence in situ hybridization

1 reference

12 December 2020

10.1371/JOURNAL.PONE.0002572

Identifiers

DOI

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26 July 2017

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26 July 2017

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