A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity (Q33333429)

25 July 2017

title

A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity (English)

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25 July 2017

Corrado Santocanale

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Alessia Montagnoli

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25 July 2017

Barbara Valsasina

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25 July 2017

Valter Croci

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25 July 2017

Maria Menichincheri

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25 July 2017

Sonia Rainoldi

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25 July 2017

Vanessa Marchesi

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25 July 2017

Marcello Tibolla

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25 July 2017

Pierluigi Tenca

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25 July 2017

Deborah Brotherton

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25 July 2017

Clara Albanese

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25 July 2017

Veronica Patton

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25 July 2017

Rachele Alzani

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25 July 2017

Antonella Ciavolella

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25 July 2017

Francesco Sola

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25 July 2017

Antonio Molinari

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25 July 2017

Daniele Volpi

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25 July 2017

Nilla Avanzi

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25 July 2017

Francesco Fiorentini

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25 July 2017

Marina Cattoni

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25 July 2017

Sandra Healy

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25 July 2017

Dario Ballinari

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25 July 2017

Enrico Pesenti

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25 July 2017

Antonella Isacchi

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25 July 2017

Jurgen Moll

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25 July 2017

Aaron Bensimon

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25 July 2017

Ermes Vanotti

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25 July 2017

publication date

11 May 2008

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25 July 2017

published in

Nature Chemical Biology

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25 July 2017

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25 July 2017

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25 July 2017

page(s)

357-365

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A novel growth- and cell cycle-regulated protein, ASK, activates human Cdc7-related kinase and is essential for G1/S transition in mammalian cells

25 July 2017

cites work

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DNA replication in eukaryotic cells

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7 January 2021

Checking on DNA damage in S phase

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7 January 2021

The DNA damage response during DNA replication

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7 January 2021

Determinants of resistance to 2',2'-difluorodeoxycytidine (gemcitabine).

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Molecular mechanisms of drug resistance

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7 January 2021

Genetic control of the cell division cycle in yeast

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7 January 2021

Human and Xenopus cDNAs encoding budding yeast Cdc7-related kinases: invitro phosphorylation of MCM subunits by a putative human homologue of Cdc7

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7 January 2021

Identification and characterization of a human protein kinase related to budding yeast Cdc7p

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7 January 2021

A human homolog of the yeast CDC7 gene is overexpressed in some tumors and transformed cell lines

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7 January 2021

Mammalian Cdc7-Dbf4 protein kinase complex is essential for initiation of DNA replication

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7 January 2021

Inactivation of Cdc7 kinase in mouse ES cells results in S-phase arrest and p53-dependent cell death

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7 January 2021

Cdc7 inhibition reveals a p53-dependent replication checkpoint that is defective in cancer cells

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7 January 2021

Drf1, a novel regulatory subunit for human Cdc7 kinase

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7 January 2021

Identification of Mcm2 phosphorylation sites by S-phase-regulating kinases

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7 January 2021

Eukaryotic MCM proteins: beyond replication initiation

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7 January 2021

1 reference

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7 January 2021

Cdc7 is an active kinase in human cancer cells undergoing replication stress.

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.90

7 January 2021

Control of DNA replication and its potential clinical exploitation.

1 reference

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7 January 2021

Cell type-specific responses of human cells to inhibition of replication licensing

1 reference

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7 January 2021

Cdc7 kinase inhibitors: pyrrolopyridinones as potential antitumor agents. 1. Synthesis and structure-activity relationships

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.90

7 January 2021

Pyrrolopyridine inhibitors of mitogen-activated protein kinase-activated protein kinase 2 (MK-2)

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.90

7 January 2021

3-Aminopyrazole inhibitors of CDK2/cyclin A as antitumor agents. 1. Lead finding

1 reference

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7 January 2021

PHA-680632, a novel Aurora kinase inhibitor with potent antitumoral activity.

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7 January 2021

Features of selective kinase inhibitors

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7 January 2021

Cyclin-dependent kinase pathways as targets for cancer treatment

1 reference

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7 January 2021

Investigating RNA polymerase II carboxyl-terminal domain (CTD) phosphorylation.

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.90

7 January 2021

Cdc7 kinase mediates Claspin phosphorylation in DNA replication checkpoint

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.90

7 January 2021

Combined depletion of cell cycle and transcriptional cyclin-dependent kinase activities induces apoptosis in cancer cells

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.90

7 January 2021

Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.90

7 January 2021

Combined application of parallel artificial membrane permeability assay and Caco-2 permeability assays in drug discovery

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.90

7 January 2021

Single molecule analysis of DNA replication

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.90

7 January 2021

Kinetic model of DNA replication in eukaryotic organisms

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.90

7 January 2021

Replication fork velocities at adjacent replication origins are coordinately modified during DNA replication in human cells

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.90

7 January 2021

Issues and progress with protein kinase inhibitors for cancer treatment

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7 January 2021

Mechanisms of drug inhibition of signalling molecules

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.90

7 January 2021

Functional profiling of the Saccharomyces cerevisiae genome

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.90

7 January 2021

Cdk9 is an essential kinase in Drosophila that is required for heat shock gene expression, histone methylation and elongation factor recruitment.

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.90

7 January 2021

Direct inhibition of CDK9 blocks HIV-1 replication without preventing T-cell activation in primary human peripheral blood lymphocytes

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.90

7 January 2021

Inhibition of human immunodeficiency virus type 1 replication by RNA interference directed against human transcription elongation factor P-TEFb (CDK9/CyclinT1).

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.90

7 January 2021

Profiling essential genes in human mammary cells by multiplex RNAi screening

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.90

7 January 2021

AZ703, an imidazo[1,2-a]pyridine inhibitor of cyclin-dependent kinases 1 and 2, induces E2F-1-dependent apoptosis enhanced by depletion of cyclin-dependent kinase 9.

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.90

7 January 2021

Natural and synthetic progestins accelerate 7,12-dimethylbenz[a]anthracene-initiated mammary tumors and increase angiogenesis in Sprague-Dawley rats

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.90

7 January 2021

DNA replication origin plasticity and perturbed fork progression in human inverted repeats

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.90

7 January 2021

Predictive pharmacokinetic-pharmacodynamic modeling of tumor growth kinetics in xenograft models after administration of anticancer agents

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.90

7 January 2021

Identifiers

DOI

10.1038/NCHEMBIO.90

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25 July 2017

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