A K ATP channel-dependent pathway within alpha cells regulates glucagon release from both rodent and human islets of Langerhans. (Q33284703)

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30 December 2019

title

A K ATP channel-dependent pathway within alpha cells regulates glucagon release from both rodent and human islets of Langerhans (English)

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Paul R V Johnson

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Reshma Ramracheya

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author name string

Yang Zhang De Marinis

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Xiaosong Ma

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English

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publication date

1 June 2007

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page(s)

e143

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Creative Commons Attribution 4.0 International

30 December 2019

start time

15 May 2007

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April 2022 Public Data File from Crossref

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cites work

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The prevalent Glu23Lys polymorphism in the potassium inward rectifier 6.2 (KIR6.2) gene is associated with impaired glucagon suppression in response to hyperglycemia

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Localized calcium influx in pancreatic beta-cells: its significance for Ca2+-dependent insulin secretion from the islets of Langerhans

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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Regulation of glucagon secretion at low glucose concentrations: evidence for adenosine triphosphate-sensitive potassium channel involvement

31 October 2018

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Glucose stimulates glucagon release in single rat alpha-cells by mechanisms that mirror the stimulus-secretion coupling in beta-cells

31 October 2018

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Impaired glucagon secretory responses in mice lacking the type 1 sulfonylurea receptor

31 October 2018

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Beta-cell secretory products activate alpha-cell ATP-dependent potassium channels to inhibit glucagon release

31 October 2018

1 reference

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Increased glucose tolerance in N-type Ca2+ channel alpha(1B)-subunit gene-deficient mice

31 October 2018

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Loss of the decrement in intraislet insulin plausibly explains loss of the glucagon response to hypoglycemia in insulin-deficient diabetes: documentation of the intraislet insulin hypothesis in humans

31 October 2018

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ATP-sensitive K+ channel-dependent regulation of glucagon release and electrical activity by glucose in wild-type and SUR1-/- mouse alpha-cells

31 October 2018

1 reference

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Hypothalamic ATP-sensitive K + channels play a key role in sensing hypoglycemia and triggering counterregulatory epinephrine and glucagon responses

31 October 2018

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Mechanism, temporal patterns, and magnitudes of the metabolic responses to the KATP channel agonist diazoxide

31 October 2018

1 reference

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Regulation of alpha-cell function by the beta-cell in isolated human and rat islets deprived of glucose: the "switch-off" hypothesis

31 October 2018

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A store-operated mechanism determines the activity of the electrically excitable glucagon-secreting pancreatic alpha-cell

31 October 2018

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Islet beta-cell secretion determines glucagon release from neighbouring alpha-cells.

31 October 2018

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Intraislet hyperinsulinemia prevents the glucagon response to hypoglycemia despite an intact autonomic response

31 October 2018

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ATP-sensitive K+ channels in the hypothalamus are essential for the maintenance of glucose homeostasis.

31 October 2018

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Regulation of glucagon release in mouse -cells by KATP channels and inactivation of TTX-sensitive Na+ channels

31 October 2018

1 reference

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Tight coupling between electrical activity and exocytosis in mouse glucagon-secreting alpha-cells

31 October 2018

1 reference

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Different effects of tolbutamide and diazoxide in alpha, beta-, and delta-cells within intact islets of Langerhans.

31 October 2018

1 reference

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The Berson memorial lecture. Insulin-glucagon relationships in the defense against hypoglycemia

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1868042

Immuno-localization of sulphonylurea receptor 1 in rat pancreas

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1868042

Sulfonylurea-binding sites and ATP-sensitive K+ channels in alpha-TC glucagonoma and beta-TC insulinoma cells

31 October 2018

1 reference

12 December 2020

Effect of physiological hyperinsulinemia on counterregulatory hormone responses during hypoglycemia in humans

1 reference

12 December 2020

The role of calcium in glucagon release. Interactions between arginine and calcium

1 reference

12 December 2020

Localization of the ATP-Sensitive K+ Channel Subunit Kir6.2 in Mouse Pancreas

1 reference

12 December 2020

Characterisation of sulphonylurea and ATP-regulated K+ channels in rat pancreatic A-cells

1 reference

12 December 2020

A High Concentration of Circulating Insulin Suppresses the Glucagon Response to Hypoglycemia in Normal Man*

1 reference

12 December 2020

10.1371/JOURNAL.PBIO.0050143

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17503968%20AND%20SRC:MED&resulttype=core&format=json

30 December 2019

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30 December 2019

PubMed publication ID

17503968

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