Mechanistic basis for inflammation and tumor promotion in lungs of 2,6-di-tert-butyl-4-methylphenol-treated mice: electrophilic metabolites alkylate and inactivate antioxidant enzymes (Q33274189)

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English	Mechanistic basis for inflammation and tumor promotion in lungs of 2,6-di-tert-butyl-4-methylphenol-treated mice: electrophilic metabolites alkylate and inactivate antioxidant enzymes	scientific article

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

25 July 2017

Mechanistic basis for inflammation and tumor promotion in lungs of 2,6-di-tert-butyl-4-methylphenol-treated mice: electrophilic metabolites alkylate and inactivate antioxidant enzymes (English)

1 reference

Europe PubMed Central

PubMed publication ID

25 July 2017

0 references

Tumor promotion

1 reference

based on heuristic

inferred from title

author name string

Brent W Meier

1

1 reference

Europe PubMed Central

PubMed publication ID

25 July 2017

Jose D Gomez

2

1 reference

Europe PubMed Central

PubMed publication ID

25 July 2017

Oleg V Kirichenko

3

1 reference

Europe PubMed Central

PubMed publication ID

25 July 2017

John A Thompson

4

1 reference

Europe PubMed Central

PubMed publication ID

25 July 2017

publication date

1 February 2007

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Europe PubMed Central

PubMed publication ID

25 July 2017

Chemical Research in Toxicology

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Europe PubMed Central

PubMed publication ID

25 July 2017

20

1 reference

Europe PubMed Central

PubMed publication ID

25 July 2017

2

1 reference

Europe PubMed Central

PubMed publication ID

25 July 2017

199-207

1 reference

Europe PubMed Central

PubMed publication ID

25 July 2017

Cell signaling. H2O2, a necessary evil for cell signaling

1 reference

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21 June 2018

Immunochemical and proteomic analysis of covalent adducts formed by quinone methide tumor promoters in mouse lung epithelial cell lines

1 reference

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The role of Keap1 in cellular protective responses

1 reference

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Characterization of a structurally intact in situ lung model and comparison of naphthalene protein adducts generated in this model vs lung microsomes.

1 reference

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21 June 2018

Peroxiredoxin 6, a 1-Cys peroxiredoxin, functions in antioxidant defense and lung phospholipid metabolism

1 reference

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21 June 2018

Inhibition of glutathione S-transferase P1-1 in mouse lung epithelial cells by the tumor promoter 2,6-di-tert-butyl-4-methylene-2,5-cyclohexadienone (BHT-quinone methide): protein adducts investigated by electrospray mass spectrometry.

1 reference

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21 June 2018

Protein profiling of mouse livers with peroxisome proliferator-activated receptor alpha activation

1 reference

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21 June 2018

Antioxidant enzymes and redox regulating thiol proteins in malignancies of human lung

1 reference

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21 June 2018

Oxidative stress and cell signalling

1 reference

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1 reference

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Activation of the antioxidant enzyme 1-CYS peroxiredoxin requires glutathionylation mediated by heterodimerization with pi GST.

1 reference

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21 June 2018

Reduced selenium-binding protein 1 expression is associated with poor outcome in lung adenocarcinomas

1 reference

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21 June 2018

Structure, mechanism and regulation of peroxiredoxins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2570584

21 June 2018

Carbonyl reductase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2570584

21 June 2018

Phospholipid hydroperoxides are substrates for non-selenium glutathione peroxidase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2570584

21 June 2018

Investigation of some covalent and noncovalent complexes by matrix-assisted laser desorption/ionization time-of-flight and electrospray mass spectrometry

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2570584

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Crystallographic structures of bovine copper-zinc superoxide dismutase reveal asymmetry in two subunits: functionally important three and five coordinate copper sites captured in the same crystal

1 reference

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Identification of the hepatic protein targets of reactive metabolites of acetaminophen in vivo in mice using two-dimensional gel electrophoresis and mass spectrometry

1 reference

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21 June 2018

Crystal structure of a novel human peroxidase enzyme at 2.0 A resolution

1 reference

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21 June 2018

Butylated hydroxytoluene exposure is necessary to induce lung tumors in BALB mice treated with 3-methylcholanthrene.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2570584

21 June 2018

Quantitative profiling of tissue- and gender-related expression of glutathione S-transferase isoenzymes in the mouse.

1 reference

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21 June 2018

Crystal structure of the ternary complex of mouse lung carbonyl reductase at 1.8 A resolution: the structural origin of coenzyme specificity in the short-chain dehydrogenase/reductase family

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2570584

21 June 2018

Contributions of mass spectrometry to peptide and protein structure

1 reference

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Inhibition by pentachlorophenol of the initiating and promoting activities of 1'-hydroxysafrole for the formation of enzyme-altered foci and tumors in rat liver.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2570584

21 June 2018

Metabolism and pulmonary toxicity of butylated hydroxytoluene (BHT).

1 reference

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21 June 2018

Free radical-derived quinone methide mediates skin tumor promotion by butylated hydroxytoluene hydroperoxide: expanded role for electrophiles in multistage carcinogenesis

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A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

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21 June 2018

Loss of PKC-delta alters cardiac metabolism

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2570584

31 October 2018

Peroxiredoxins, a novel protein family in lung cancer

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2570584

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The Drosophila carbonyl reductase sniffer prevents oxidative stress-induced neurodegeneration.

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31 October 2018

Responses of tumorigenic and non-tumorigenic mouse lung epithelial cell lines to electrophilic metabolites of the tumor promoter butylated hydroxytoluene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2570584

31 October 2018

Lung toxicity and tumor promotion by hydroxylated derivatives of 2,6-di-tert-butyl-4-methylphenol (BHT) and 2-tert-butyl-4-methyl-6-iso-propylphenol: correlation with quinone methide reactivity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2570584

31 October 2018

Extensive investigations on oxidized amino acid residues in H(2)O(2)-treated Cu,Zn-SOd protein with LC-ESI-Q-TOF-MS, MS/MS for the determination of the copper-binding site

1 reference

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31 October 2018

Butylated hydroxytoluene (BHT) induction of pulmonary inflammation: a role in tumor promotion

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2570584

31 October 2018

Studies using structural analogs and inbred strain differences to support a role for quinone methide metabolites of butylated hydroxytoluene (BHT) in mouse lung tumor promotion

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31 October 2018

Spectrophotometric assay of superoxide dismutase activity based on the activated autoxidation of a tetracyclic catechol.

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Glutathione S-transferase and glutathione peroxidase expression in normal and tumour human tissues

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31 October 2018

Carbonyl reductase and NADPH cytochrome P450 reductase activities in human tumoral versus normal tissues

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12 December 2020

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The small G-protein Rac mediates depolarization-induced superoxide formation in human endothelial cells

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https://pubmed.ncbi.nlm.nih.gov/17305404

12 December 2020

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Mouse liver selenium-binding protein decreased in abundance by peroxisome proliferators

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https://pubmed.ncbi.nlm.nih.gov/17305404

12 December 2020

based on heuristic

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Oxidation of butylated hydroxytoluene to toxic metabolites. Factors influencing hydroxylation and quinone methide formation by hepatic and pulmonary microsomes

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https://pubmed.ncbi.nlm.nih.gov/17305404

12 December 2020

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Influence of quinone methide reactivity on the alkylation of thiol and amino groups in proteins: studies utilizing amino acid and peptide models

1 reference

https://pubmed.ncbi.nlm.nih.gov/17305404

12 December 2020

based on heuristic

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Identifiers

10.1021/TX060214F

1 reference

Europe PubMed Central

PubMed publication ID

25 July 2017

PMC publication ID

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Europe PubMed Central

PubMed publication ID

25 July 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

25 July 2017

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