Finding new tricks for old drugs: an efficient route for public-sector drug discovery (Q33229063)

24 July 2017

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title

Finding new tricks for old drugs: an efficient route for public-sector drug discovery (English)

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24 July 2017

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Kerry A O'Connor

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24 July 2017

Bryan L Roth

series ordinal

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24 July 2017

publication date

1 December 2005

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Nature Reviews Drug Discovery

24 July 2017

published in

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24 July 2017

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24 July 2017

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24 July 2017

page(s)

1005-1014

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Finishing the euchromatic sequence of the human genome

24 July 2017

cites work

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Chemical genomic profiling of biological networks using graph theory and combinations of small molecule perturbations

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Mining the receptorome

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Magic shotguns versus magic bullets: selectively non-selective drugs for mood disorders and schizophrenia

21 January 2018

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High-throughput screening of the yeast kinome: identification of human serine/threonine protein kinases that phosphorylate the hepatitis C virus NS5A protein

21 January 2018

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Kinomics: methods for deciphering the kinome

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The protein kinase complement of the human genome

21 January 2018

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21 January 2018

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Drug repositioning: identifying and developing new uses for existing drugs

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Multicomponent therapeutics for networked systems

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Antimicrobial-Drug Prescription in Ambulatory Care Settings, United States, 1992–2000

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Beta-lactam antibiotics offer neuroprotection by increasing glutamate transporter expression.

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Knockout of glutamate transporters reveals a major role for astroglial transport in excitotoxicity and clearance of glutamate

21 January 2018

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Altered expression of the glutamate transporter EAAT2b in neurological disease

21 January 2018

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Merits of a new drug trial for ALS?

21 January 2018

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New insights into progressive multifocal leukoencephalopathy

21 January 2018

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The human polyomavirus, JCV, uses serotonin receptors to infect cells

21 January 2018

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The dynamin-dependent, arrestin-independent internalization of 5-hydroxytryptamine 2A (5-HT2A) serotonin receptors reveals differential sorting of arrestins and 5-HT2A receptors during endocytosis

21 January 2018

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Drug safety. Withdrawal of Vioxx casts a shadow over COX-2 inhibitors

21 January 2018

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Valvular heart disease associated with fenfluramine-phentermine

21 January 2018

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Appetite Suppressants and Valvular Heart Disease

21 January 2018

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Evidence for possible involvement of 5-HT(2B) receptors in the cardiac valvulopathy associated with fenfluramine and other serotonergic medications

21 January 2018

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3,4-methylenedioxymethamphetamine (MDMA, "Ecstasy") induces fenfluramine-like proliferative actions on human cardiac valvular interstitial cells in vitro

21 January 2018

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Function of the serotonin 5-hydroxytryptamine 2B receptor in pulmonary hypertension

21 January 2018

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Differential actions of antiparkinson agents at multiple classes of monoaminergic receptor. III. Agonist and antagonist properties at serotonin, 5-HT(1) and 5-HT(2), receptor subtypes

21 January 2018

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The US Food and Drug Administration's registry of patients with pergolide-associated valvular heart disease

21 January 2018

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Treatment of Parkinson's disease with pergolide and relation to restrictive valvular heart disease

21 January 2018

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Severe multivalvular heart disease: a new complication of the ergot derivative dopamine agonists

21 January 2018

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Anorexigenic and ancillary actions of MK-212 (6-chloro-2-[1-piperazinyl]-pyrazine; CPP)

21 January 2018

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Multiple serotonin receptors: opportunities for new treatments for obesity?

21 January 2018

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Insights into the structure and function of 5-HT(2) family serotonin receptors reveal novel strategies for therapeutic target development

21 January 2018

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Regulation of beta-amyloid stimulated proinflammatory responses by peroxisome proliferator-activated receptor alpha

21 January 2018

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Diverse compounds mimic Alzheimer disease-causing mutations by augmenting Abeta42 production

21 January 2018

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The highly efficacious actions of N-desmethylclozapine at muscarinic receptors are unique and not a common property of either typical or atypical antipsychotic drugs: is M1 agonism a pre-requisite for mimicking clozapine's actions?

21 January 2018

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Differential distribution of the JC virus receptor-type sialic acid in normal human tissues

21 January 2018

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Ceftriaxone is ineffective in ALS

21 January 2018

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Attrition and Translation

21 January 2018

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Molecular medicine. NIH dives into drug discovery

31 March 2020

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[Blocking adhesion molecules with natalizumab in multiple sclerosis].

31 March 2020

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Megestrol acetate vs cyproheptadine in the treatment of weight loss associated with HIV infection

31 March 2020

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Reduced satiating effect of d -fenfluramine in serotonin 5-HT 2C receptor mutant mice

31 March 2020

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Anti-inflammatory drug therapy alters beta-amyloid processing and deposition in an animal model of Alzheimer's disease.

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRD1900

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release_3eaq44pk5bhbpiidolmahyrcl4

24 July 2017

Fatcat ID

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Fatcat

https://api.fatcat.wiki/v0/release/3eaq44pk5bhbpiidolmahyrcl4

mapped directly with Wikidata item

24 November 2022

based on heuristic

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