Site-directed mutagenesis of K396R of the 65 kDa glutamic acid decarboxylase active site obliterates enzyme activity but not antibody binding. (Q31864279)

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English	Site-directed mutagenesis of K396R of the 65 kDa glutamic acid decarboxylase active site obliterates enzyme activity but not antibody binding.	scientific article

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3 November 2019

Site-directed mutagenesis of K396R of the 65 kDa glutamic acid decarboxylase active site obliterates enzyme activity but not antibody binding (English)

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3 November 2019

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Christiane S Hampe

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3 November 2019

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L P Hammerle

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3 November 2019

A Falorni

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J Robertson

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A Lernmark

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3 November 2019

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3 November 2019

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3 November 2019

Motifs and structural fold of the cofactor binding site of human glutamate decarboxylase

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21 January 2018

Structural characteristics of brain glutamate decarboxylase in relation to its interaction and activation

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Direct Brønsted analysis of the restoration of activity to a mutant enzyme by exogenous amines

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Lysine-69 plays a key role in catalysis by ornithine decarboxylase through acceleration of the Schiff base formation, decarboxylation, and product release steps

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Glutamate decarboxylase-, insulin-, and islet cell-antibodies and HLA typing to detect diabetes in a general population-based study of Swedish children

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Immune response to glutamic acid decarboxylase correlates with insulitis in non-obese diabetic mice.

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Spontaneous loss of T-cell tolerance to glutamic acid decarboxylase in murine insulin-dependent diabetes

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Baculovirus-mediated expression of human 65 kDa and 67 kDa glutamic acid decarboxylases in SF9 insect cells and their relevance in diagnosis of insulin-dependent diabetes mellitus

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Brain glutamate decarboxylase cloned in lambda gt-11: fusion protein produces gamma-aminobutyric acid

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21 January 2018

Two human glutamate decarboxylases, 65-kDa GAD and 67-kDa GAD, are each encoded by a single gene

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21 January 2018

Non-steady-state kinetics of brain glutamate decarboxylase resulting from interconversion of the apo- and holoenzyme

1 reference

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21 January 2018

Serum exchange and use of dilutions have improved precision of measurement of islet cell antibodies.

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GAD autoantibodies in IDDM, stiff-man syndrome, and autoimmune polyendocrine syndrome type I recognize different epitopes

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21 January 2018

Purification and some properties of L-glutamate decarboxylase from human brain

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Effect of substitution of a lysyl residue that binds pyridoxal phosphate in thermostable D-amino acid aminotransferase by arginine and alanine

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An anomalous side reaction of the Lys303 mutant aromatic L-amino acid decarboxylase unravels the role of the residue in catalysis

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64,000 Mr autoantibodies as predictors of insulin-dependent diabetes

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Antibodies to a Mr-64000 islet cell protein in Swedish children with newly diagnosed Type 1 (insulin-dependent) diabetes

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21 January 2018

Combined use of autoantibodies (IA-2 autoantibody, GAD autoantibody, insulin autoantibody, cytoplasmic islet cell antibodies) in type 1 diabetes: Combinatorial Islet Autoantibody Workshop

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Administering glutamic acid decarboxylase to NOD mice prevents diabetes

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Development of the methylotrophic yeast Pichia methanolica for the expression of the 65 kilodalton isoform of human glutamate decarboxylase

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A novel method for expression and large-scale production of human brain l-glutamate decarboxylase

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A novel radioligand binding assay to determine diagnostic accuracy of isoform-specific glutamic acid decarboxylase antibodies in childhood IDDM

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21 January 2018

Radioimmunoassays for glutamic acid decarboxylase (GAD65) and GAD65 autoantibodies using 35S or 3H recombinant human ligands

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21 January 2018

High level of concordance between assays for glutamic acid decarboxylase antibodies. The First International Glutamic Acid Decarboxylase Antibody Workshop

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Radioimmunoassay detects the frequent occurrence of autoantibodies to the Mr 65,000 isoform of glutamic acid decarboxylase in Japanese insulin-dependent diabetes

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21 January 2018

Differential detection of rat islet and brain glutamic acid decarboxylase (GAD) isoforms with sequence-specific peptide antibodies

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Glutamic acid decarboxylase cDNA: nucleotide sequence encoding an enzymatically active fusion protein

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