Assessing the Impact of Tissue Target Concentration Data on Uncertainty in In Vivo Target Coverage Predictions (Q31138430)

4 October 2017

Assessing the Impact of Tissue Target Concentration Data on Uncertainty in In Vivo Target Coverage Predictions (English)

1 reference

4 October 2017

A Tiwari

1 reference

4 October 2017

H Luo

1 reference

4 October 2017

X Chen

1 reference

4 October 2017

P Singh

1 reference

4 October 2017

I Bhattacharya

1 reference

4 October 2017

P Jasper

1 reference

4 October 2017

J E Tolsma

1 reference

4 October 2017

H M Jones

1 reference

4 October 2017

A Zutshi

1 reference

4 October 2017

A K Abraham

1 reference

4 October 2017

language of work or name

1 reference

22 October 2016

1 reference

CPT: pharmacometrics & systems pharmacology

4 October 2017

1 reference

4 October 2017

1 reference

4 October 2017

1 reference

4 October 2017

565-574

1 reference

A mechanistic PK/PD model for two anti-IL13 antibodies explains the difference in total IL-13 accumulation observed in clinical studies

4 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5080652

New horizons in therapeutic antibody discovery: opportunities and challenges versus small-molecule therapeutics

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5080652

Incorporating Target Shedding Into a Minimal PBPK-TMDD Model for Monoclonal Antibodies

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5080652

Second-generation minimal physiologically-based pharmacokinetic model for monoclonal antibodies

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5080652

Basic concepts in physiologically based pharmacokinetic modeling in drug discovery and development

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5080652

Dose selection based on physiologically based pharmacokinetic (PBPK) approaches

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5080652

Tissue bioanalysis of biotherapeutics and drug targets to support PK/PD.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5080652

Targeted drug delivery by gemtuzumab ozogamicin: mechanism-based mathematical model for treatment strategy improvement and therapy individualization

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5080652

Population Pharmacokinetics of Therapeutic Monoclonal Antibodies

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5080652

Systematic calibration of a cell signaling network model

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5080652

Target-mediated drug disposition model: approximations, identifiability of model parameters and applications to the population pharmacokinetic-pharmacodynamic modeling of biologics

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5080652

In vivo regulation of interleukin 1beta in patients with cryopyrin-associated periodic syndromes

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5080652

A methodology for performing global uncertainty and sensitivity analysis in systems biology.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5080652

Protein therapeutics: a summary and pharmacological classification

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5080652

Universally sloppy parameter sensitivities in systems biology models

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5080652

Cytokines in the pathogenesis of rheumatoid arthritis

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5080652

How modeling and simulation have enhanced decision making in new drug development

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5080652

Adalimumab, a fully human anti-tumor necrosis factor alpha monoclonal antibody, for the treatment of rheumatoid arthritis in patients taking concomitant methotrexate: the ARMADA trial

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5080652

Breaking the affinity ceiling for antibodies and T cell receptors

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5080652

Role of cytokines in the pathogenesis of inflammatory bowel disease

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5080652

Infliximab (chimeric anti-tumour necrosis factor alpha monoclonal antibody) versus placebo in rheumatoid arthritis patients receiving concomitant methotrexate: a randomised phase III trial. ATTRACT Study Group

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5080652

Measurement of tissue protein synthesis rates in vivo: a critical analysis of contrasting methods

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5080652

Biodistribution of monoclonal antibodies: scale-up from mouse to human using a physiologically based pharmacokinetic model

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5080652

Pharmacokinetics, single-dose tolerance, and biological activity of recombinant gamma-interferon in cancer patients

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5080652

Recombinant human TNF-alpha: preclinical studies and results from early clinical trials

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5080652

Secukinumab distributes into dermal interstitial fluid of psoriasis patients as demonstrated by open flow microperfusion.

21 June 2018

1 reference

https://api.crossref.org/works/10.1002%2FPSP4.12126

General pharmacokinetic model for drugs exhibiting target-mediated drug disposition

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPSP4.12126

Quasi-equilibrium pharmacokinetic model for drugs exhibiting target-mediated drug disposition.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPSP4.12126

Approximations of the target-mediated drug disposition model and identifiability of model parameters.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPSP4.12126

Towards a platform PBPK model to characterize the plasma and tissue disposition of monoclonal antibodies in preclinical species and human

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPSP4.12126

Local versus systemic anti-tumour necrosis factor-α effects of adalimumab in rheumatoid arthritis: pharmacokinetic modelling analysis of interaction between a soluble target and a drug

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPSP4.12126

Highly specific and sensitive measurements of human and monkey interleukin 21 using sequential protein and tryptic peptide immunoaffinity LC-MS/MS.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPSP4.12126

Cytokines: Principles and prospects

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPSP4.12126

Comparative pharmacokinetics of single-dose administration of mammalian and bacterially-derived recombinant human granulocyte-macrophage colony-stimulating factor.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5080652

Cytokines in skin lesions of psoriasis

25 November 2018

1 reference

12 December 2020

Highly increased levels of tumor necrosis factor-alpha and other proinflammatory cytokines in psoriatic arthritis synovial fluid

1 reference

12 December 2020

Quantitative analysis of target coverage and germinal center response by a CXCL13 neutralizing antibody in a T-dependent mouse immunization model

1 reference

12 December 2020

Simulations of site-specific target-mediated pharmacokinetic models for guiding the development of bispecific antibodies

1 reference

12 December 2020

Identifiers

DOI

10.1002/PSP4.12126

1 reference

4 October 2017

1 reference

4 October 2017

PubMed publication ID

27770597

1 reference