Treatment with the PI3K inhibitor buparlisib (NVP-BKM120) suppresses the growth of established patient-derived GBM xenografts and prolongs survival in nude rats. (Q31106994)

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English	Treatment with the PI3K inhibitor buparlisib (NVP-BKM120) suppresses the growth of established patient-derived GBM xenografts and prolongs survival in nude rats.	scientific article

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13 March 2020

Treatment with the PI3K inhibitor buparlisib (NVP-BKM120) suppresses the growth of established patient-derived GBM xenografts and prolongs survival in nude rats (English)

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13 March 2020

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Mohummad Aminur Rahman

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13 March 2020

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I A Netland

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13 March 2020

H E Førde

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L Sleire

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13 March 2020

L Leiss

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13 March 2020

B S Skeie

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H Miletic

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P Ø Enger

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D Goplen

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9 June 2016

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13 March 2020

Journal of Neuro-Oncology

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13 March 2020

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13 March 2020

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13 March 2020

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9 June 2016

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Inhibition of phosphatidylinositol 3-kinase/AKT signaling by NVP-BKM120 promotes ABT-737-induced toxicity in a caspase-dependent manner through mitochondrial dysfunction and DNA damage response in established and primary cultured glioblastoma cells

1 reference

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14 July 2018

Phase I dose-escalation and -expansion study of buparlisib (BKM120), an oral pan-Class I PI3K inhibitor, in patients with advanced solid tumors

1 reference

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PI3K and cancer: lessons, challenges and opportunities

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14 July 2018

Phase I dose-escalation study of buparlisib (BKM120), an oral pan-class I PI3K inhibitor, in Japanese patients with advanced solid tumors

1 reference

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Phosphatidylinositol 3-kinase (PI3K) inhibitors as cancer therapeutics.

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The somatic genomic landscape of glioblastoma

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Overcoming acquired resistance to anticancer therapy: focus on the PI3K/AKT/mTOR pathway

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Current clinical development of PI3K pathway inhibitors in glioblastoma

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14 July 2018

Phase I, dose-escalation study of BKM120, an oral pan-Class I PI3K inhibitor, in patients with advanced solid tumors

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Antitumor activity of NVP-BKM120--a selective pan class I PI3 kinase inhibitor showed differential forms of cell death based on p53 status of glioma cells

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Current Review of in Vivo GBM Rodent Models: Emphasis on the CNS-1 Tumour Model

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Preclinical modeling of combined phosphatidylinositol-3-kinase inhibition with endocrine therapy for estrogen receptor-positive breast cancer

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A reproducible brain tumour model established from human glioblastoma biopsies

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Highly infiltrative brain tumours show reduced chemosensitivity associated with a stem cell-like phenotype

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Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial

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The 2007 WHO classification of tumours of the central nervous system

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10.1007/S11060-016-2158-1

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13 March 2020

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13 March 2020

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13 March 2020

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