High-affinity CRF1 receptor antagonist NBI-34041: preclinical and clinical data suggest safety and efficacy in attenuating elevated stress response (Q31099140)

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English	High-affinity CRF1 receptor antagonist NBI-34041: preclinical and clinical data suggest safety and efficacy in attenuating elevated stress response	scientific article

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scholarly article

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Europe PubMed Central

PubMed publication ID

28 June 2017

High-affinity CRF1 receptor antagonist NBI-34041: preclinical and clinical data suggest safety and efficacy in attenuating elevated stress response (English)

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Europe PubMed Central

PubMed publication ID

28 June 2017

Florian Holsboer

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Florian Holsboer

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Manfred Uhr

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Marcus Ising

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author name string

Ulrich S Zimmermann

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Europe PubMed Central

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28 June 2017

Heike E Künzel

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PubMed publication ID

28 June 2017

Alan C Foster

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Europe PubMed Central

PubMed publication ID

28 June 2017

Susan M Learned-Coughlin

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28 June 2017

Dimitri E Grigoriadis

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28 June 2017

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publication date

7 February 2007

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28 June 2017

Neuropsychopharmacology

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28 June 2017

32

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Europe PubMed Central

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28 June 2017

9

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28 June 2017

1941-1949

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28 June 2017

Psychiatric implications of basic and clinical studies with corticotropin-releasing factor

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21 January 2018

Reduced corticotropin releasing factor binding sites in the frontal cortex of suicide victims

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21 January 2018

CSF corticotropin-releasing hormone in depressed patients and normal control subjects

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21 January 2018

Corticotropin-releasing factor receptor antagonists in affective disorders and drug dependence-- an update

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21 January 2018

Corticotropin releasing hormone receptors: two decades later

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7 January 2021

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CRF signaling: molecular specificity for drug targeting in the CNS.

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7 January 2021

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Activating and 'anxiogenic' effects of corticotropin releasing factor are not inhibited by blockade of the pituitary-adrenal system with dexamethasone

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https://api.crossref.org/works/10.1038%2FSJ.NPP.1301328

7 January 2021

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Localization of novel corticotropin-releasing factor receptor (CRF2) mRNA expression to specific subcortical nuclei in rat brain: comparison with CRF1 receptor mRNA expression

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7 January 2021

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Stress and the brain: from adaptation to disease

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7 January 2021

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Dimensions of arousal: wakefulness and vigor

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7 January 2021

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The corticotropin-releasing factor receptor: a novel target for the treatment of depression and anxiety-related disorders

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7 January 2021

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Design and synthesis of tricyclic corticotropin-releasing factor-1 antagonists

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7 January 2021

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International Union of Pharmacology. XXXVI. Current status of the nomenclature for receptors for corticotropin-releasing factor and their ligands

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7 January 2021

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Corticotropin-releasing factor CRF1, but not CRF2, receptors mediate anxiogenic-like behavior

1 reference

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7 January 2021

based on heuristic

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Treatment with the CRH1-receptor-antagonist R121919 improves sleep-EEG in patients with depression

1 reference

https://api.crossref.org/works/10.1038%2FSJ.NPP.1301328

7 January 2021

based on heuristic

inferred from DOI database lookup

Expression of corticotropin releasing hormone receptors type I and type II mRNA in suicide victims and controls

1 reference

https://api.crossref.org/works/10.1038%2FSJ.NPP.1301328

7 January 2021

based on heuristic

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ACTH and multisteroid responses to corticotropin-releasing factor in depressive illness: Relationship to multisteroid responses after ACTH stimulation and dexamethasone suppression☆

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

The combined dexamethasone/CRH test as a potential surrogate marker in depression

1 reference

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7 January 2021

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The 'Trier Social Stress Test'--a tool for investigating psychobiological stress responses in a laboratory setting

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Treatment with a CRH-1-receptor antagonist (R121919) does not affect weight or plasma leptin concentration in patients with major depression

1 reference

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7 January 2021

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Treatment of depression with the CRH-1-receptor antagonist R121919: endocrine changes and side effects

1 reference

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7 January 2021

based on heuristic

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Differential behavioural effects of chronic infusion of CRH 1 and CRH 2 receptor antisense oligonucleotides into the rat brain

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Chronic infusion of a CRH1 receptor antisense oligodeoxynucleotide into the central nucleus of the amygdala reduced anxiety-related behavior in socially defeated rats

1 reference

https://api.crossref.org/works/10.1038%2FSJ.NPP.1301328

7 January 2021

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Dysregulation in the suicide brain: mRNA expression of corticotropin-releasing hormone receptors and GABA(A) receptor subunits in frontal cortical brain region.

1 reference

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7 January 2021

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Limbic corticotropin-releasing hormone receptor 1 mediates anxiety-related behavior and hormonal adaptation to stress.

1 reference

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7 January 2021

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Neuropeptide concentrations in the cerebrospinal fluid of depressed patients treated with electroconvulsive therapy. Corticotrophin-releasing factor, beta-endorphin and somatostatin

1 reference

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7 January 2021

based on heuristic

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Elevated Concentrations of CSF Corticotropin-Releasing Factor-Like Immunoreactivity in Depressed Patients

1 reference

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7 January 2021

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Impaired type II glucocorticoid-receptor function in mice bearing antisense RNA transgene

1 reference

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7 January 2021

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Foot-shock induced stress increases β-endorphin levels in blood but not brain

1 reference

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7 January 2021

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Antagonists of the corticotropin releasing factor receptor

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7 January 2021

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The neurobiology of urocortin

1 reference

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7 January 2021

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Corticotropin-releasing hormone receptor (type I) antisense targeting reduces anxiety

1 reference

https://api.crossref.org/works/10.1038%2FSJ.NPP.1301328

7 January 2021

based on heuristic

inferred from DOI database lookup

Age- and stimulus-dependent changes in anxiety-related behaviour of transgenic mice with GR dysfunction

1 reference

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7 January 2021

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Effect of ethanol on hypothalamic-pituitary-adrenal system response to psychosocial stress in sons of alcohol-dependent fathers

1 reference

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7 January 2021

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Effects of the high-affinity corticotropin-releasing hormone receptor 1 antagonist R121919 in major depression: the first 20 patients treated

1 reference

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7 January 2021

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The therapeutic potential of CRF1 antagonists for anxiety

1 reference

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7 January 2021

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inferred from DOI database lookup

Identifiers

10.1038/SJ.NPP.1301328

1 reference

Europe PubMed Central

PubMed publication ID

28 June 2017

Dimensions Publication ID

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PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

28 June 2017

ResearchGate publication ID

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