A new structural model of Alzheimer's Aβ42 fibrils based on electron paramagnetic resonance data and Rosetta modeling (Q31041418)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26827680%20AND%20SRC:MED&resulttype=core&format=json

6 March 2020

title

A new structural model of Alzheimer's Aβ42 fibrils based on electron paramagnetic resonance data and Rosetta modeling (English)

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6 March 2020

0 references

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6 March 2020

Lei Gu

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6 March 2020

Joyce Tran

series ordinal

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6 March 2020

Lin Jiang

series ordinal

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6 March 2020

publication date

28 January 2016

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Journal of Structural Biology

6 March 2020

published in

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6 March 2020

volume

194

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6 March 2020

issue

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6 March 2020

page(s)

61-67

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Peptide dimer structure in an Aβ(1-42) fibril visualized with cryo-EM.

6 March 2020

cites work

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High resolution structural characterization of Aβ42 amyloid fibrils by magic angle spinning NMR.

21 June 2018

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Aβ(1-42) fibril structure illuminates self-recognition and replication of amyloid in Alzheimer's disease

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Antiparallel triple-strand architecture for prefibrillar Aβ42 oligomers

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Structural insights into Aβ42 oligomers using site-directed spin labeling

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Structural basis for increased toxicity of pathological aβ42:aβ40 ratios in Alzheimer disease

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Neurotoxicity of Alzheimer's disease Aβ peptides is induced by small changes in the Aβ42 to Aβ40 ratio

21 June 2018

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21 June 2018

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21 June 2018

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Interprotofilament interactions between Alzheimer's Abeta1-42 peptides in amyloid fibrils revealed by cryoEM

21 June 2018

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Fibrils with parallel in-register structure constitute a major class of amyloid fibrils: molecular insights from electron paramagnetic resonance spectroscopy

21 June 2018

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21 June 2018

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The ratio of monomeric to aggregated forms of Abeta40 and Abeta42 is an important determinant of amyloid-beta aggregation, fibrillogenesis, and toxicity

21 June 2018

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Prediction of the structure of symmetrical protein assemblies

21 June 2018

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Investigation of alpha-synuclein fibril structure by site-directed spin labeling

21 June 2018

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Stable activity of a deubiquitylating enzyme (Usp2-cc) in the presence of high concentrations of urea and its application to purify aggregation-prone peptides

21 June 2018

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Molecular structure of amyloid fibrils: insights from solid-state NMR.

21 June 2018

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Inhibitors of amyloid toxicity based on beta-sheet packing of Abeta40 and Abeta42.

21 June 2018

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Experimental constraints on quaternary structure in Alzheimer's beta-amyloid fibrils

21 June 2018

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3D structure of Alzheimer's amyloid-beta(1-42) fibrils

21 June 2018

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Abeta42 is essential for parenchymal and vascular amyloid deposition in mice

21 June 2018

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Design of a Novel Globular Protein Fold with Atomic-Level Accuracy

21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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25 November 2018

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25 November 2018

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Key residues for the oligomerization of Aβ42 protein in Alzheimer's disease.

25 November 2018

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25 November 2018

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Verification of the C-terminal intramolecular beta-sheet in Abeta42 aggregates using solid-state NMR: implications for potent neurotoxicity through the formation of radicals.

25 November 2018

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25 November 2018

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The solvent protection of alzheimer amyloid-beta-(1-42) fibrils as determined by solution NMR spectroscopy.

25 November 2018

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Verification of the turn at positions 22 and 23 of the beta-amyloid fibrils with Italian mutation using solid-state NMR.

25 November 2018

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Analysis of the secondary structure of beta-amyloid (Abeta42) fibrils by systematic proline replacement

25 November 2018

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Supramolecular structural constraints on Alzheimer's beta-amyloid fibrils from electron microscopy and solid-state nuclear magnetic resonance.

25 November 2018

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Structural and dynamic features of Alzheimer's Abeta peptide in amyloid fibrils studied by site-directed spin labeling.

25 November 2018

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Molecular motion of spin labeled side chains in alpha-helices: analysis by variation of side chain structure

25 November 2018

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Peptide compositions of the cerebrovascular and senile plaque core amyloid deposits of Alzheimer's disease

25 November 2018

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Amyloid beta protein (A beta) in Alzheimer's disease brain. Biochemical and immunocytochemical analysis with antibodies specific for forms ending at A beta 40 or A beta 42(43).

25 November 2018

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Polyclonals to beta-amyloid(1-42) identify most plaque and vascular deposits in Alzheimer cortex, but not striatum

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Abeta40 protects non-toxic Abeta42 monomer from aggregation

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Identifiers

DOI

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26827680%20AND%20SRC:MED&resulttype=core&format=json

6 March 2020

1 reference

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6 March 2020

PubMed publication ID

26827680

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26827680%20AND%20SRC:MED&resulttype=core&format=json