(19)F NMR and DFT Analysis Reveal Structural and Electronic Transition State Features for RhoA-Catalyzed GTP Hydrolysis (Q31040971)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26822702%20AND%20SRC:MED&resulttype=core&format=json

6 March 2020

title

(19)F NMR and DFT Analysis Reveal Structural and Electronic Transition State Features for RhoA-Catalyzed GTP Hydrolysis (English)

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6 March 2020

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6 March 2020

1 reference

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6 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26822702%20AND%20SRC:MED&resulttype=core&format=json

6 March 2020

Nigel G J Richards

1 reference

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6 March 2020

G Michael Blackburn

series ordinal

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6 March 2020

language of work or name

English

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publication date

28 January 2016

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Angewandte Chemie International Edition

6 March 2020

published in

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6 March 2020

volume

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6 March 2020

issue

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6 March 2020

page(s)

3318-3322

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Modeling the mechanisms of biological GTP hydrolysis

6 March 2020

cites work

1 reference

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α-Fluorophosphonates reveal how a phosphomutase conserves transition state conformation over hexose recognition in its two-step reaction.

21 June 2018

1 reference

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Quantitative exploration of the molecular origin of the activation of GTPase

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4770445

Regulation of small GTPases by GEFs, GAPs, and GDIs

21 June 2018

1 reference

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Reflections on biocatalysis involving phosphorus.

21 June 2018

1 reference

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Ras and GTPase-activating protein (GAP) drive GTP into a precatalytic state as revealed by combining FTIR and biomolecular simulations

21 June 2018

1 reference

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Near attack conformers dominate -phosphoglucomutase complexes where geometry and charge distribution reflect those of substrate

21 June 2018

1 reference

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Biological phosphoryl-transfer reactions: understanding mechanism and catalysis

21 June 2018

1 reference

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Transition state analogue structures of human phosphoglycerate kinase establish the importance of charge balance in catalysis

21 June 2018

1 reference

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Atomic details of near-transition state conformers for enzyme phosphoryl transfer revealed by Formula rather than by phosphoranes

21 June 2018

1 reference

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Progress in ab initio QM/MM free-energy simulations of electrostatic energies in proteins: accelerated QM/MM studies of pKa, redox reactions and solvation free energies

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4770445

The GAP arginine finger movement into the catalytic site of Ras increases the activation entropy

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4770445

A Trojan horse transition state analogue generated by MgF3- formation in an enzyme active site.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4770445

A newly designed microspectrofluorometer for kinetic studies on protein crystals in combination with x-ray diffraction

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4770445

Phosphoryl transfer in Ras proteins, conclusive or elusive?

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4770445

Crystallographic evidence for substrate-assisted GTP hydrolysis by a small GTP binding protein

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4770445

Why does the Ras switch "break" by oncogenic mutations?

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4770445

Quantum chemical studies of intermediates and reaction pathways in selected enzymes and catalytic synthetic systems

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4770445

MgF(3)(-) as a transition state analog of phosphoryl transfer

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4770445

RanGAP mediates GTP hydrolysis without an arginine finger

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4770445

How does GAP catalyze the GTPase reaction of Ras? A computer simulation study

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4770445

Structure at 1.65 A of RhoA and its GTPase-activating protein in complex with a transition-state analogue

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4770445

The Ras-RasGAP Complex: Structural Basis for GTPase Activation and Its Loss in Oncogenic Ras Mutants

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4770445

Structures of active conformations of Gi alpha 1 and the mechanism of GTP hydrolysis

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4770445

GTPase mechanism of Gproteins from the 1.7-A crystal structure of transducin alpha-GDP-AIF-4

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4770445

Refined crystal structure of the triphosphate conformation of H-ras p21 at 1.35 A resolution: implications for the mechanism of GTP hydrolysis

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4770445

Hydrolysis of Guanosine Triphosphate (GTP) by the Ras·GAP Protein Complex: Reaction Mechanism and Kinetic Scheme.

21 June 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201509477

Substrate-assisted catalysis as a mechanism for GTP hydrolysis of p21ras and other GTP-binding proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201509477

Charge-balanced metal fluoride complexes for protein kinase A with adenosine diphosphate and substrate peptide SP20.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201509477

Computational study of a transition state analog of phosphoryl transfer in the Ras-RasGAP complex: AlF(x) versus MgF3-.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201509477

Role of the arginine finger in Ras.RasGAP revealed by QM/MM calculations

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201509477

The M06 suite of density functionals for main group thermochemistry, thermochemical kinetics, noncovalent interactions, excited states, and transition elements: two new functionals and systematic testing of four M06-class functionals and 12 other fun

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201509477

How do the GTPases really work?

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26822702

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1002/ANIE.201509477

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26822702%20AND%20SRC:MED&resulttype=core&format=json

6 March 2020

1 reference

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6 March 2020

PubMed publication ID

26822702

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26822702%20AND%20SRC:MED&resulttype=core&format=json