Promoter methylation and large intragenic rearrangements of DPYD are not implicated in severe toxicity to 5-fluorouracil-based chemotherapy in gastrointestinal cancer patients (Q30988828)

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English	Promoter methylation and large intragenic rearrangements of DPYD are not implicated in severe toxicity to 5-fluorouracil-based chemotherapy in gastrointestinal cancer patients	scientific article

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

16 October 2017

Promoter methylation and large intragenic rearrangements of DPYD are not implicated in severe toxicity to 5-fluorouracil-based chemotherapy in gastrointestinal cancer patients (English)

1 reference

Europe PubMed Central

PMC publication ID

16 October 2017

0 references

10

1 reference

Europe PubMed Central

PMC publication ID

16 October 2017

Carmen Jeronimo

11

1 reference

Europe PubMed Central

PMC publication ID

16 October 2017

Joana Savva-Bordalo

object named as

Joana Savva-Bordalo

1

0 references

object named as

Isabel Veiga

7

0 references

João Ramalho-Carvalho

object named as

João Ramalho-Carvalho

2

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Manuela Pinheiro

object named as

Manuela Pinheiro

3

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Manuel R. Teixeira

object named as

Manuel R Teixeira

9

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author name string

Vera L Costa

4

1 reference

Europe PubMed Central

PMC publication ID

16 October 2017

Angelo Rodrigues

5

1 reference

Europe PubMed Central

PMC publication ID

16 October 2017

Paula C Dias

6

1 reference

Europe PubMed Central

PMC publication ID

16 October 2017

Manuela Machado

8

1 reference

Europe PubMed Central

PMC publication ID

16 October 2017

language of work or name

0 references

publication date

1 September 2010

1 reference

Europe PubMed Central

PMC publication ID

16 October 2017

1 reference

Europe PubMed Central

PMC publication ID

16 October 2017

10

1 reference

Europe PubMed Central

PMC publication ID

16 October 2017

1

1 reference

13 September 2019

470

1 reference

Europe PubMed Central

PMC publication ID

16 October 2017

Absence of large intragenic rearrangements in the DPYD gene in a large cohort of colorectal cancer patients treated with 5-FU-based chemotherapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2940808

14 July 2018

Hypermethylation of the DPYD promoter region is not a major predictor of severe toxicity in 5-fluorouracil based chemotherapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2940808

14 July 2018

Predicting fluorouracil toxicity: can we finally do it?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2940808

14 July 2018

Prognostic significance of thymidylate synthase, dihydropyrimidine dehydrogenase and thymidine phosphorylase protein expression in colorectal cancer patients treated with or without 5-fluorouracil-based chemotherapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2940808

14 July 2018

Suppression of DPYD expression in RKO cells via DNA methylation in the regulatory region of the DPYD promoter: a potentially important epigenetic mechanism regulating DPYD expression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2940808

14 July 2018

Cancer epigenomics: DNA methylomes and histone-modification maps

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2940808

14 July 2018

Dihydropyrimidine dehydrogenase and the efficacy and toxicity of 5-fluorouracil

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2940808

14 July 2018

Clinical implications of dihydropyrimidine dehydrogenase (DPD) activity in 5-FU-based chemotherapy: mutations in the DPD gene, and DPD inhibitory fluoropyrimidines

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2940808

14 July 2018

5-Fluorouracil: mechanisms of action and clinical strategies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2940808

14 July 2018

Relative quantification of 40 nucleic acid sequences by multiplex ligation-dependent probe amplification

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2940808

14 July 2018

Prevalence of a common point mutation in the dihydropyrimidine dehydrogenase (DPD) gene within the 5'-splice donor site of intron 14 in patients with severe 5-fluorouracil (5-FU)- related toxicity compared with controls.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2940808

14 July 2018

Comparison between short or long exposure to 5-fluorouracil in human gastric and colon cancer cell lines: biochemical mechanism of resistance.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2940808

14 July 2018

A modified and improved method for bisulphite based cytosine methylation analysis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2940808

14 July 2018

High sensitivity mapping of methylated cytosines

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2940808

14 July 2018

5-Fluorouracil incorporation into RNA and DNA in relation to thymidylate synthase inhibition of human colorectal cancers

1 reference

https://api.crossref.org/works/10.1186%2F1471-2407-10-470

21 January 2018

Role of genetic and nongenetic factors for fluorouracil treatment-related severe toxicity: a prospective clinical trial by the German 5-FU Toxicity Study Group

1 reference

https://api.crossref.org/works/10.1186%2F1471-2407-10-470

21 January 2018

Analysis of severely affected patients with dihydropyrimidine dehydrogenase deficiency reveals large intragenic rearrangements of DPYD and a de novo interstitial deletion del(1)(p13.3p21.3).

1 reference

https://api.crossref.org/works/10.1186%2F1471-2407-10-470

21 January 2018

Aberrant methylation of DPYD promoter, DPYD expression, and cellular sensitivity to 5-fluorouracil in cancer cells

1 reference

https://api.crossref.org/works/10.1186%2F1471-2407-10-470

21 January 2018

Methylation of the DPYD promoter: an alternative mechanism for dihydropyrimidine dehydrogenase deficiency in cancer patients

1 reference

https://api.crossref.org/works/10.1186%2F1471-2407-10-470

21 January 2018

MethylQuant: a real-time PCR-based method to quantify DNA methylation at single specific cytosines.

1 reference

https://api.crossref.org/works/10.1186%2F1471-2407-10-470

21 January 2018

Mutations in exon 14 of dihydropyrimidine dehydrogenase and 5-Fluorouracil toxicity in Portuguese colorectal cancer patients

1 reference

https://api.crossref.org/works/10.1186%2F1471-2407-10-470

21 January 2018

Lack of large intragenic rearrangements in dihydropyrimidine dehydrogenase (DPYD) gene in fluoropyrimidine-treated patients with high-grade toxicity

1 reference

https://api.crossref.org/works/10.1186%2F1471-2407-10-470

21 January 2018

Combination of dihydropyrimidine dehydrogenase and thymidylate synthase gene expressions in primary tumors as predictive parameters for the efficacy of fluoropyrimidine-based chemotherapy for metastatic colorectal cancer.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2940808

25 November 2018

Epigenetic patterns in the progression of esophageal adenocarcinoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2940808

25 November 2018

DNA extraction from tissue

1 reference

https://pubmed.ncbi.nlm.nih.gov/20809970

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genetic variations and haplotype structures of the DPYD gene encoding dihydropyrimidine dehydrogenase in Japanese and their ethnic differences

1 reference

https://pubmed.ncbi.nlm.nih.gov/20809970

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Known variant DPYD alleles do not explain DPD deficiency in cancer patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/20809970

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Facilitated transport of uracil and 5-fluorouracil, and permeation of orotic acid into cultured mammalian cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/20809970

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1186/1471-2407-10-470

1 reference

Europe PubMed Central

PMC publication ID

16 October 2017

Dimensions Publication ID

0 references

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

16 October 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

16 October 2017

ResearchGate publication ID

0 references

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