Discovery of a small molecule Tat-trans-activation-responsive RNA antagonist that potently inhibits human immunodeficiency virus-1 replication (Q30962300)

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English	Discovery of a small molecule Tat-trans-activation-responsive RNA antagonist that potently inhibits human immunodeficiency virus-1 replication	scientific article

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scholarly article

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Europe PubMed Central

PubMed publication ID

27 June 2017

Discovery of a small molecule Tat-trans-activation-responsive RNA antagonist that potently inhibits human immunodeficiency virus-1 replication (English)

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Europe PubMed Central

PubMed publication ID

27 June 2017

7

object named as

Kuan-Teh Jeang

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Europe PubMed Central

PubMed publication ID

27 June 2017

author name string

Seongwoo Hwang

1

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Europe PubMed Central

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27 June 2017

Natarajan Tamilarasu

2

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Europe PubMed Central

PubMed publication ID

27 June 2017

Karen Kibler

3

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Europe PubMed Central

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27 June 2017

Hong Cao

4

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Europe PubMed Central

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27 June 2017

Akbar Ali

5

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Europe PubMed Central

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27 June 2017

Yueh-Hsin Ping

6

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Europe PubMed Central

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27 June 2017

Tariq M Rana

8

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Europe PubMed Central

PubMed publication ID

27 June 2017

language of work or name

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publication date

11 July 2003

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27 June 2017

Journal of Biological Chemistry

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27 June 2017

278

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Europe PubMed Central

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27 June 2017

40

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Europe PubMed Central

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27 June 2017

39092-39103

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Europe PubMed Central

PubMed publication ID

27 June 2017

Taking a new TAK on tat transactivation

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https://api.crossref.org/works/10.1074%2FJBC.M301749200

21 January 2018

HIV-1 auxiliary proteins: making connections in a dying cell

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301749200

21 January 2018

HIV-1 regulatory/accessory genes: keys to unraveling viral and host cell biology

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301749200

21 January 2018

Tat transactivation: a model for the regulation of eukaryotic transcriptional elongation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301749200

21 January 2018

Multifaceted activities of the HIV-1 transactivator of transcription, Tat.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301749200

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301749200

21 January 2018

Multiple functional domains of Tat, the trans-activator of HIV-1, defined by mutational analysis

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https://api.crossref.org/works/10.1074%2FJBC.M301749200

21 January 2018

Specific interaction of the human immunodeficiency virus Tat proteins with a cellular protein kinase.

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https://api.crossref.org/works/10.1074%2FJBC.M301749200

21 January 2018

Transcription elongation factor P-TEFb is required for HIV-1 tat transactivation in vitro

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https://api.crossref.org/works/10.1074%2FJBC.M301749200

21 January 2018

P-TEFb kinase is required for HIV Tat transcriptional activation in vivo and in vitro

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301749200

21 January 2018

Recruitment of cyclin T1/P-TEFb to an HIV type 1 long terminal repeat promoter proximal RNA target is both necessary and sufficient for full activation of transcription

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301749200

21 January 2018

HIV-1 TAR RNA enhances the interaction between Tat and cyclin T1.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301749200

21 January 2018

Tat trans-activates the human immunodeficiency virus through a nascent RNA target

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301749200

21 January 2018

The location of cis-acting regulatory sequences in the human T cell lymphotropic virus type III (HTLV-III/LAV) long terminal repeat

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301749200

21 January 2018

A discrete element 3' of human immunodeficiency virus 1 (HIV-1) and HIV-2 mRNA initiation sites mediates transcriptional activation by an HIV trans activator

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301749200

21 January 2018

RNA as a drug target: chemical, modelling, and evolutionary tools

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301749200

21 January 2018

RNA as a target for small molecules.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301749200

21 January 2018

Targeting RNA with small-molecule drugs: therapeutic promise and chemical challenges

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301749200

21 January 2018

Discovery of selective, small-molecule inhibitors of RNA complexes--I. The Tat protein/TAR RNA complexes required for HIV-1 transcription

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301749200

21 January 2018

An inhibitor of the Tat/TAR RNA interaction that effectively suppresses HIV-1 replication

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301749200

21 January 2018

Inhibitors of protein-RNA complexation that target the RNA: specific recognition of human immunodeficiency virus type 1 TAR RNA by small organic molecules

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301749200

21 January 2018

A new class of HIV-1 Tat antagonist acting through Tat-TAR inhibition

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301749200

21 January 2018

Inhibition of gene expression in human cells through small molecule-RNA interactions

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301749200

21 January 2018

Inhibition of HIV-1 Tat-TAR interaction by diphenylfuran derivatives: effects of the terminal basic side chains

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301749200

21 January 2018

Molecular basis of HIV-1 TAR RNA specific recognition by an acridine tat-antagonist

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301749200

21 January 2018

Identification of ligands for RNA targets via structure-based virtual screening: HIV-1 TAR.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301749200

21 January 2018

Inhibition of HIV-1 Tat-dependent trans activation by steric block chimeric 2'-O-methyl/LNA oligoribonucleotides.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301749200

21 January 2018

Structure-based computational database screening, in vitro assay, and NMR assessment of compounds that target TAR RNA.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301749200

21 January 2018

Complex synthetic chemical libraries indexed with molecular tags

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301749200

21 January 2018

Human immunodeficiency virus type-1 Tat is an integral component of the activated transcription-elongation complex

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301749200

21 January 2018

Tat-associated kinase (P-TEFb): a component of transcription preinitiation and elongation complexes

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301749200

21 January 2018

Neomycin B-arginine conjugate, a novel HIV-1 Tat antagonist: synthesis and anti-HIV activities

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301749200

21 January 2018

Aminoglycoside neurotoxicity involves NMDA receptor activation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301749200

21 January 2018

Inhibitors of strand transfer that prevent integration and inhibit HIV-1 replication in cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301749200

21 January 2018

Controlling human immunodeficiency virus type 1 gene expression by unnatural peptides

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301749200

21 January 2018

Tat and trans-activation-responsive (TAR) RNA-independent induction of HIV-1 long terminal repeat by human and murine cyclin T1 requires Sp1.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301749200

21 January 2018

DSIF and NELF interact with RNA polymerase II elongation complex and HIV-1 Tat stimulates P-TEFb-mediated phosphorylation of RNA polymerase II and DSIF during transcription elongation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301749200

21 January 2018

Biochemical and functional interactions between HIV-1 Tat protein and TAR RNA.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301749200

21 January 2018

Efficient method for the preparation of peptoids [oligo(N-substituted glycines)] by submonomer solid-phase synthesis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301749200

21 January 2018

A Structural Basis for RNAminus signLigand Interactions

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301749200

21 January 2018

Design and analysis of molecular motifs for specific recognition of RNA

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301749200

21 January 2018

Identifiers

10.1074/JBC.M301749200

1 reference

Europe PubMed Central

PubMed publication ID

27 June 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

27 June 2017

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