Aggrecanase versus matrix metalloproteinases in the catabolism of the interglobular domain of aggrecan in vitro. (Q30807179)

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1 November 2019

title

Aggrecanase versus matrix metalloproteinases in the catabolism of the interglobular domain of aggrecan in vitro (English)

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1 November 2019

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1 November 2019

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1 November 2019

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1 November 2019

Flannery CR

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1 November 2019

Mort JS

series ordinal

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1 November 2019

Roughley PJ

series ordinal

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Dent C

series ordinal

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1 November 2019

language of work or name

English

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publication date

1 November 1999

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1 November 2019

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1 November 2019

volume

344 Pt 1

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1 November 2019

page(s)

61-68

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Cytokine-induced cartilage proteoglycan degradation is mediated by aggrecanase

1 November 2019

cites work

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Characterization of aggrecan retained and lost from the extracellular matrix of articular cartilage. Involvement of carboxyl-terminal processing in the catabolism of aggrecan

14 July 2018

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Membrane type 1 matrix metalloproteinase (MT1-MMP) cleaves the recombinant aggrecan substrate rAgg1mut at the 'aggrecanase' and the MMP sites. Characterization of MT1-MMP catabolic activities on the interglobular domain of aggrecan

14 July 2018

1 reference

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Molecular cloning and sequence analysis of the aggrecan interglobular domain from porcine, equine, bovine and ovine cartilage: comparison of proteinase-susceptible regions and sites of keratan sulfate substitution.

14 July 2018

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Aggrecan degradation in human cartilage. Evidence for both matrix metalloproteinase and aggrecanase activity in normal, osteoarthritic, and rheumatoid joints

14 July 2018

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Temporal pattern of cysteine endopeptidase (cathepsin B) expression in cartilage and synovium from rabbit knees with experimental osteoarthritis: gene expression in chondrocytes in response to interleukin-1 and matrix depletion

14 July 2018

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Aggrecan is degraded by matrix metalloproteinases in human arthritis. Evidence that matrix metalloproteinase and aggrecanase activities can be independent

14 July 2018

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Anabolic and catabolic markers of proteoglycan metabolism in osteoarthritis.

14 July 2018

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A cartilage explant system for studies on aggrecan structure, biosynthesis and catabolism in discrete zones of the mammalian growth plate

14 July 2018

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Fibroblast and neutrophil collagenases cleave at two sites in the cartilage aggrecan interglobular domain

14 July 2018

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Neutrophil collagenase (MMP-8) cleaves at the aggrecanase site E373-A374 in the interglobular domain of cartilage aggrecan

14 July 2018

1 reference

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Cell-mediated catabolism of aggrecan. Evidence that cleavage at the "aggrecanase" site (Glu373-Ala374) is a primary event in proteolysis of the interglobular domain

14 July 2018

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Cathepsin B in osteoarthritis: cytochemical and histochemical analysis of human femoral head cartilage

14 July 2018

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Quantification of a matrix metalloproteinase-generated aggrecan G1 fragment using monospecific anti-peptide serum

14 July 2018

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N- and O-Linked Keratan Sulfate on the Hyaluronan Binding Region of Aggrecan from Mature and Immature Bovine Cartilage

14 July 2018

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Development of a cleavage-site-specific monoclonal antibody for detecting metalloproteinase-derived aggrecan fragments: detection of fragments in human synovial fluids

14 July 2018

1 reference

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Monoclonal antibodies that specifically recognize neoepitope sequences generated by 'aggrecanase' and matrix metalloproteinase cleavage of aggrecan: application to catabolism in situ and in vitro

14 July 2018

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Improved quantitation and discrimination of sulphated glycosaminoglycans by use of dimethylmethylene blue

14 July 2018

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Cleavage of cartilage proteoglycan between G1 and G2 domains by stromelysins

14 July 2018

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N-terminal sequence of proteoglycan fragments isolated from medium of interleukin-1-treated articular-cartilage cultures. Putative site(s) of enzymic cleavage

14 July 2018

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The structure of aggrecan fragments in human synovial fluid. Evidence for the involvement in osteoarthritis of a novel proteinase which cleaves the Glu 373-Ala 374 bond of the interglobular domain

14 July 2018

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Mechanism of catabolism of aggrecan by articular cartilage

14 July 2018

1 reference

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Regulation of matrix metabolism in equine cartilage explant cultures by interleukin 1.

14 July 2018

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Hyaluronan-binding region of aggrecan from pig laryngeal cartilage. Amino acid sequence, analysis of N-linked oligosaccharides and location of the keratan sulphate

14 July 2018

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Monoclonal antibodies recognizing protease-generated neoepitopes from cartilage proteoglycan degradation. Application to studies of human link protein cleavage by stromelysin.

14 July 2018

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The interglobular domain of cartilage aggrecan is cleaved by PUMP, gelatinases, and cathepsin B

14 July 2018

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Effects of culture conditions and exposure to catabolic stimulators (IL-1 and retinoic acid) on the expression of matrix metalloproteinases (MMPs) and disintegrin metalloproteinases (ADAMs) by articular cartilage chondrocytes

14 July 2018

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Cathepsin B: an alternative protease for the generation of an aggrecan 'metalloproteinase' cleavage neoepitope

25 November 2018

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Immunolocalization of the cleavage of the aggrecan core protein at the Asn341-Phe342 bond, as an indicator of the location of the metalloproteinases active in the lysis of the rat growth plate

25 November 2018

1 reference

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Knee joint immobilization decreases aggrecan gene expression in the meniscus

25 November 2018

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Aggrecan degradation in human intervertebral disc and articular cartilage

25 November 2018

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Use of an antibody against the matrix metalloproteinase-generated aggrecan neoepitope FVDIPEN-COOH to assess the effects of stromelysin in a rabbit model of cartilage degradation

25 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1220614

Identification of a stromelysin cleavage site within the interglobular domain of human aggrecan. Evidence for proteolysis at this site in vivo in human articular cartilage

25 November 2018

1 reference

12 December 2020

A matrix metalloproteinase-generated aggrecan neoepitope as a marker of skeletal maturation and aging in cartilage

1 reference

12 December 2020

Aggrecanase and metalloproteinase-specific aggrecan neo-epitopes are induced in the articular cartilage of mice with collagen II-induced arthritis

1 reference

12 December 2020

Differential Expression of Aggrecanase and Matrix Metalloproteinase Activity in Chondrocytes Isolated from Bovine and Porcine Articular Cartilage

1 reference

12 December 2020

Kinetics of aggrecanase- and metalloproteinase-induced neoepitopes in various stages of cartilage destruction in murine arthritis

1 reference

12 December 2020

Catabolism of aggrecan in cartilage explants. Identification of a major cleavage site within the interglobular domain

1 reference

12 December 2020

The structure of aggrecan fragments in human synovial fluid. Evidence that aggrecanase mediates cartilage degradation in inflammatory joint disease, joint injury, and osteoarthritis

1 reference

12 December 2020

Excess of metalloproteases over tissue inhibitor of metalloprotease may contribute to cartilage degradation in osteoarthritis and rheumatoid arthritis

1 reference

12 December 2020

10.1042/0264-6021:3440061

Identifiers

DOI

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2 November 2017

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1 November 2019

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1 November 2019

PubMed publication ID

10548534

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