Detection of Mutant Huntingtin Aggregation Conformers and Modulation of SDS-Soluble Fibrillar Oligomers by Small Molecules (Q30547549)

19 October 2017

Detection of Mutant Huntingtin Aggregation Conformers and Modulation of SDS-Soluble Fibrillar Oligomers by Small Molecules (English)

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19 October 2017

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19 October 2017

Charles G Glabe

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19 October 2017

Emily Mitchell Sontag

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19 October 2017

Gregor P Lotz

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19 October 2017

Guocheng Yang

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19 October 2017

Christopher J Sontag

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19 October 2017

Paul J Muchowski

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19 October 2017

Leslie Michels Thompson

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19 October 2017

1 January 2012

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Journal of Huntington's Disease

19 October 2017

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19 October 2017

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19 October 2017

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19 October 2017

119-132

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Creative Commons Attribution-NonCommercial 4.0 International

19 October 2017

start time

1 January 2012

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April 2022 Public Data File from Crossref

copyrighted

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describes a project that uses

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3786168/fullTextXML

inferred from PubMed Central ID database lookup

cites work

Identifying polyglutamine protein species in situ that best predict neurodegeneration

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Amyloid-β annular protofibrils evade fibrillar fate in Alzheimer disease brain

20 June 2018

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Hsp70 and Hsp40 Functionally Interact with Soluble Mutant Huntingtin Oligomers in a Classic ATP-dependent Reaction Cycle

20 June 2018

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Prion-like transmission of protein aggregates in neurodegenerative diseases

20 June 2018

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Mutant huntingtin fragments form oligomers in a polyglutamine length-dependent manner in vitro and in vivo

20 June 2018

1 reference

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Prion-like mechanisms in neurodegenerative diseases

20 June 2018

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Fibrillar oligomers nucleate the oligomerization of monomeric amyloid beta but do not seed fibril formation

20 June 2018

1 reference

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Identical oligomeric and fibrillar structures captured from the brains of R6/2 and knock-in mouse models of Huntington's disease

20 June 2018

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Soluble fibrillar oligomer levels are elevated in Alzheimer's disease brain and correlate with cognitive dysfunction

20 June 2018

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CEP-1347 reduces mutant huntingtin-associated neurotoxicity and restores BDNF levels in R6/2 mice

20 June 2018

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EGCG redirects amyloidogenic polypeptides into unstructured, off-pathway oligomers

20 June 2018

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A small-molecule therapeutic lead for Huntington's disease: preclinical pharmacology and efficacy of C2-8 in the R6/2 transgenic mouse

20 June 2018

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Fibril specific, conformation dependent antibodies recognize a generic epitope common to amyloid fibrils and fibrillar oligomers that is absent in prefibrillar oligomers

20 June 2018

1 reference

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Conformation-dependent anti-amyloid oligomer antibodies

20 June 2018

1 reference

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Mutant huntingtin alters MAPK signaling pathways in PC12 and striatal cells: ERK1/2 protects against mutant huntingtin-associated toxicity.

20 June 2018

1 reference

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Identification of combinatorial drug regimens for treatment of Huntington's disease using Drosophila.

20 June 2018

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A potent small molecule inhibits polyglutamine aggregation in Huntington's disease neurons and suppresses neurodegeneration in vivo

20 June 2018

1 reference

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Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death

20 June 2018

1 reference

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Conformation-dependent antibodies target diseases of protein misfolding

20 June 2018

1 reference

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Mixed-lineage kinases: a target for the prevention of neurodegeneration

20 June 2018

1 reference

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A cell-based assay for aggregation inhibitors as therapeutics of polyglutamine-repeat disease and validation in Drosophila

20 June 2018

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Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis

20 June 2018

1 reference

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K252a and CEP1347 are neuroprotective compounds that inhibit mixed-lineage kinase-3 and induce activation of Akt and ERK.

20 June 2018

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The threshold for polyglutamine-expansion protein aggregation and cellular toxicity is dynamic and influenced by aging in Caenorhabditis elegans

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3786168

The MLK family mediates c-Jun N-terminal kinase activation in neuronal apoptosis

20 June 2018

1 reference

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Aggresomes, inclusion bodies and protein aggregation

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3786168

Hsp70 and hsp40 chaperones can inhibit self-assembly of polyglutamine proteins into amyloid-like fibrils

20 June 2018

1 reference

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Disassembly of nuclear inclusions in the dividing cell--a novel insight into neurodegeneration

20 June 2018

1 reference

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Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3786168

Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation

20 June 2018

1 reference

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Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice

20 June 2018

1 reference

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Sensitive biochemical aggregate detection reveals aggregation onset before symptom development in cellular and murine models of Huntington's disease

20 June 2018

1 reference

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Small molecule inhibitors of aggregation indicate that amyloid beta oligomerization and fibrillization pathways are independent and distinct

26 November 2018

1 reference

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Green tea (-)-epigallocatechin-gallate modulates early events in huntingtin misfolding and reduces toxicity in Huntington's disease models

26 November 2018

1 reference

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Prefibrillar amyloid aggregates could be generic toxins in higher organisms.

26 November 2018

1 reference

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Hsp70 and Hsp40 attenuate formation of spherical and annular polyglutamine oligomers by partitioning monomer

26 November 2018

1 reference

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Huntingtin spheroids and protofibrils as precursors in polyglutamine fibrilization

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3786168

Huntingtin-encoded polyglutamine expansions form amyloid-like protein aggregates in vitro and in vivo

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3786168

Motoneuron apoptosis is blocked by CEP-1347 (KT 7515), a novel inhibitor of the JNK signaling pathway

26 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24086178

12 December 2020

inferred from PubMed ID database lookup

Observation of metastable Abeta amyloid protofibrils by atomic force microscopy

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24086178

12 December 2020

inferred from PubMed ID database lookup

1 reference

https://pubmed.ncbi.nlm.nih.gov/24086178

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.3233/JHD-2012-129004

1 reference

19 October 2017

1 reference

19 October 2017

PubMed publication ID

24086178

1 reference