A computational model to predict the effects of class I anti-arrhythmic drugs on ventricular rhythms (Q30513464)

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12 February 2020

title

A computational model to predict the effects of class I anti-arrhythmic drugs on ventricular rhythms (English)

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12 February 2020

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12 February 2020

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12 February 2020

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12 February 2020

Jonathan D Moreno

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12 February 2020

Z Iris Zhu

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12 February 2020

Pei-Chi Yang

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12 February 2020

Mao-Tsuen Jeng

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12 February 2020

Chaoyi Kang

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12 February 2020

Lianguo Wang

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12 February 2020

Jason D Bayer

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12 February 2020

David J Christini

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12 February 2020

Robert S Kass

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12 February 2020

Colleen E Clancy

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12 February 2020

language of work or name

English

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publication date

1 August 2011

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Science Translational Medicine

12 February 2020

published in

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volume

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issue

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12 February 2020

page(s)

98ra83

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Transmural heterogeneity and remodeling of ventricular excitation-contraction coupling in human heart failure

12 February 2020

cites work

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Predicting drug-induced slowing of conduction and pro-arrhythmia: identifying the 'bad' sodium current blockers

28 July 2018

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New developments in atrial antiarrhythmic drug therapy

28 July 2018

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Transmural dispersion of repolarization in failing and nonfailing human ventricle

28 July 2018

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Specificities of atrial electrophysiology: Clues to a better understanding of cardiac function and the mechanisms of arrhythmias

28 July 2018

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Multiscale modelling of drug-induced effects on cardiac electrophysiological activity

28 July 2018

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Is heart size a factor in ventricular fibrillation? Or how close are rabbit and human hearts?

28 July 2018

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Flecainide sensitivity of a Na channel long QT mutation shows an open-channel blocking mechanism for use-dependent block

28 July 2018

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State-dependent trapping of flecainide in the cardiac sodium channel

28 July 2018

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How to impose microscopic reversibility in complex reaction mechanisms

28 July 2018

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Common molecular determinants of flecainide and lidocaine block of heart Na+ channels: evidence from experiments with neutral and quaternary flecainide analogues

28 July 2018

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Channel openings are necessary but not sufficient for use-dependent block of cardiac Na(+) channels by flecainide: evidence from the analysis of disease-linked mutations

28 July 2018

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The rise of computational biology

28 July 2018

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Preferential block of late sodium current in the LQT3 DeltaKPQ mutant by the class I(C) antiarrhythmic flecainide.

28 July 2018

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Slow conduction in cardiac tissue, I: effects of a reduction of excitability versus a reduction of electrical coupling on microconduction

28 July 2018

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Local anesthetics as effectors of allosteric gating. Lidocaine effects on inactivation-deficient rat skeletal muscle Na channels

28 July 2018

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Vulnerability in an excitable medium: analytical and numerical studies of initiating unidirectional propagation

28 July 2018

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Mechanism of flecainide's rate-dependent actions on action potential duration in canine atrial tissue

28 July 2018

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On the molecular nature of the lidocaine receptor of cardiac Na+ channels. Modification of block by alterations in the alpha-subunit III-IV interdomain

28 July 2018

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Antiarrhythmic agents: the modulated receptor mechanism of action of sodium and calcium channel-blocking drugs

28 July 2018

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Effect of Flecainide on Action Potentials and Alternating Current-Induced Arrhythmias in Mammalian Myocardium

28 July 2018

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Effect of lidocaine on the electrophysiological properties of ventricular muscle and Purkinje fibers

28 July 2018

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Mechanisms of Action of Antiarrhythmic Drugs

28 July 2018

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Inhibition of ICa in single frog cardiac cells by quinidine, flecainide, ethmozin, and ethacizin

28 July 2018

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Preliminary report: effect of encainide and flecainide on mortality in a randomized trial of arrhythmia suppression after myocardial infarction

28 July 2018

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28 July 2018

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28 July 2018

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28 July 2018

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Molecular pharmacology of the sodium channel mutation D1790G linked to the long-QT syndrome

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21 January 2018

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Considerations in phase plane analysis for nonstationary reentrant cardiac behavior

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Flecainide inhibits the transient outward current in atrial myocytes isolated from the rabbit heart

21 January 2018

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12 December 2020

K+ channel blocking actions of flecainide compared with those of propafenone and quinidine in adult rat ventricular myocytes

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12 December 2020

Comparison of the effects of class I anti-arrhythmic drugs, cibenzoline, mexiletine and flecainide, on the delayed rectifier K+ current of guinea-pig ventricular myocytes

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12 December 2020

Ionic mechanisms of propagation in cardiac tissue. Roles of the sodium and L-type calcium currents during reduced excitability and decreased gap junction coupling

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12 December 2020

Alternans and spiral breakup in a human ventricular tissue model

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12 December 2020

Circus movement in rabbit atrial muscle as a mechanism of trachycardia

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12 December 2020

Effects of flecainide on the cellular electrophysiology of neonatal and adult cardiac fibers

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12 December 2020

Two molecular transitions influence cardiac sodium channel gating

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12 December 2020

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12 December 2020

Proarrhythmic response to sodium channel blockade. Theoretical model and numerical experiments

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12 December 2020

Differential block of cardiac delayed rectifier current by class Ic antiarrhythmic drugs: evidence for open channel block and unblock

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12 December 2020

10.1126/SCITRANSLMED.3002588

Identifiers

DOI

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12 February 2020

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12 February 2020

PubMed publication ID

21885405

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