The Rho GEFs LARG and GEF-H1 regulate the mechanical response to force on integrins. (Q30500836)

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1 February 2020

title

The Rho GEFs LARG and GEF-H1 regulate the mechanical response to force on integrins (English)

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1 February 2020

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1 February 2020

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1 February 2020

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1 February 2020

Vinay Swaminathan

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1 February 2020

E Timothy O'Brien

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1 February 2020

Keith Burridge

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1 February 2020

publication date

15 May 2011

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1 February 2020

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volume

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issue

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1 February 2020

page(s)

722-727

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The FERM domain: organizing the structure and function of FAK.

1 February 2020

cites work

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Myosin II activity regulates vinculin recruitment to focal adhesions through FAK-mediated paxillin phosphorylation

20 June 2018

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Size-uniform 200 nm particles: fabrication and application to magnetofection

20 June 2018

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Matrix density-induced mechanoregulation of breast cell phenotype, signaling and gene expression through a FAK-ERK linkage

20 June 2018

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Force-induced cell polarisation is linked to RhoA-driven microtubule-independent focal-adhesion sliding

20 June 2018

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Single-cell response to stiffness exhibits muscle-like behavior.

20 June 2018

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Guanine nucleotide exchange factor-H1 regulates cell migration via localized activation of RhoA at the leading edge

20 June 2018

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Cell mechanics: dissecting the physical responses of cells to force

20 June 2018

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GEF-H1 mediates tumor necrosis factor-alpha-induced Rho activation and myosin phosphorylation: role in the regulation of tubular paracellular permeability

20 June 2018

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Chapter 16: Magnetic manipulation for force measurements in cell biology

20 June 2018

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Rapid signal transduction in living cells is a unique feature of mechanotransduction.

20 June 2018

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Cellular functions of GEF-H1, a microtubule-regulated Rho-GEF: is altered GEF-H1 activity a crucial determinant of disease pathogenesis?

20 June 2018

1 reference

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ERK1/2 phosphorylate GEF-H1 to enhance its guanine nucleotide exchange activity toward RhoA.

20 June 2018

1 reference

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PyK2 and FAK connections to p190Rho guanine nucleotide exchange factor regulate RhoA activity, focal adhesion formation, and cell motility

20 June 2018

1 reference

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A novel role for Lsc/p115 RhoGEF and LARG in regulating RhoA activity downstream of adhesion to fibronectin.

20 June 2018

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GEFs and GAPs: critical elements in the control of small G proteins

20 June 2018

1 reference

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Force activates smooth muscle alpha-actin promoter activity through the Rho signaling pathway

20 June 2018

1 reference

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Matrix elasticity directs stem cell lineage specification

20 June 2018

1 reference

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Thin-foil magnetic force system for high-numerical-aperture microscopy.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3107386

Fibronectin rigidity response through Fyn and p130Cas recruitment to the leading edge

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3107386

Analysis of activated GAPs and GEFs in cell lysates

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3107386

Tensional homeostasis and the malignant phenotype

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3107386

Integrin signaling to the actin cytoskeleton.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3107386

Nucleotide exchange factor GEF-H1 mediates cross-talk between microtubules and the actin cytoskeleton

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3107386

Force transduction by Triton cytoskeletons

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3107386

Regulation of G protein-linked guanine nucleotide exchange factors for Rho, PDZ-RhoGEF, and LARG by tyrosine phosphorylation: evidence of a role for focal adhesion kinase

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3107386

RhoA inactivation by p190RhoGAP regulates cell spreading and migration by promoting membrane protrusion and polarity

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3107386

Focal contacts as mechanosensors: externally applied local mechanical force induces growth of focal contacts by an mDia1-dependent and ROCK-independent mechanism

20 June 2018

1 reference

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Mammalian MAP kinase signalling cascades

20 June 2018

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Regulation of the small GTP-binding protein Rho by cell adhesion and the cytoskeleton

20 June 2018

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Measurement of local viscoelasticity and forces in living cells by magnetic tweezers

20 June 2018

1 reference

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Cell locomotion and focal adhesions are regulated by substrate flexibility

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3107386

Regulation of cell motility by mitogen-activated protein kinase

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3107386

Integrin-mediated activation of MAP kinase is independent of FAK: evidence for dual integrin signaling pathways in fibroblasts

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3107386

Extracellular matrix rigidity causes strengthening of integrin-cytoskeleton linkages

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3107386

Rho-stimulated contractility drives the formation of stress fibers and focal adhesions

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3107386

Integrin-mediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinase

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3107386

Mechanotransduction Across the Cell Surface and Through the Cytoskeleton

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3107386

Cellular adaptation to mechanical stress: role of integrins, Rho, cytoskeletal tension and mechanosensitive ion channels

20 June 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNCB2254

Time scale dependent viscoelastic and contractile regimes in fibroblasts probed by microplate manipulation

21 January 2018

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PubMed

https://pubmed.ncbi.nlm.nih.gov/21572419

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12 December 2020

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Identifiers

DOI

10.1038/NCB2254

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Dimensions Publication ID

1 February 2020

1029006148

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24 November 2022

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1 February 2020

PubMed publication ID

21572419

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