Role of mTOR in podocyte function and diabetic nephropathy in humans and mice (Q30500731)

13 October 2017

Role of mTOR in podocyte function and diabetic nephropathy in humans and mice (English)

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13 October 2017

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Dontscho Kerjaschki

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Nadja Herbach

object named as

Nadja Herbach

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ORCID Public Data File 2021

13 October 2017

Rüdiger Wanke

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Tobias B Huber

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author name string

Markus Gödel

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13 October 2017

Björn Hartleben

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13 October 2017

Shuya Liu

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13 October 2017

Stefan Zschiedrich

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13 October 2017

Shun Lu

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13 October 2017

Andrea Debreczeni-Mór

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13 October 2017

Maja T Lindenmeyer

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13 October 2017

Maria-Pia Rastaldi

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13 October 2017

Götz Hartleben

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13 October 2017

Thorsten Wiech

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13 October 2017

Alessia Fornoni

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13 October 2017

Robert G Nelson

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13 October 2017

Clemens D Cohen

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13 October 2017

Michael N Hall

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13 October 2017

Markus A Rüegg

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13 October 2017

Ken Inoki

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13 October 2017

Gerd Walz

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13 October 2017

language of work or name

English

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publication date

23 May 2011

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Journal of Clinical Investigation

13 October 2017

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13 October 2017

121

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13 October 2017

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13 October 2017

2197-2209

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mTORC1 activation in podocytes is a critical step in the development of diabetic nephropathy in mice

13 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3104746

The story of Notch and chronic kidney disease

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3104746

Epithelial Notch signaling regulates interstitial fibrosis development in the kidneys of mice and humans

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3104746

Insulin signaling to the glomerular podocyte is critical for normal kidney function

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3104746

Autophagy influences glomerular disease susceptibility and maintains podocyte homeostasis in aging mice

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3104746

The role of the mammalian target of rapamycin (mTOR) in renal disease

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3104746

Significance and management of proteinuria in kidney transplant recipients

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3104746

mTOR signaling at a glance

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3104746

Nck proteins maintain the adult glomerular filtration barrier

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3104746

mTOR and the control of whole body metabolism

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3104746

Skeletal muscle-specific ablation of raptor, but not of rictor, causes metabolic changes and results in muscle dystrophy

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3104746

Adipose-specific knockout of raptor results in lean mice with enhanced mitochondrial respiration

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3104746

Enhanced expression of Janus kinase-signal transducer and activator of transcription pathway members in human diabetic nephropathy

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3104746

Role of TSC-mTOR pathway in diabetic nephropathy

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3104746

Tuberous sclerosis complex proteins control axon formation

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3104746

Improved elucidation of biological processes linked to diabetic nephropathy by single probe-based microarray data analysis

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3104746

VEGF inhibition and renal thrombotic microangiopathy

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3104746

A global double-fluorescent Cre reporter mouse

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3104746

The mTOR/PI3K and MAPK pathways converge on eIF4B to control its phosphorylation and activity

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3104746

Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3104746

Comparative promoter analysis allows de novo identification of specialized cell junction-associated proteins

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3104746

TOR signaling in growth and metabolism

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3104746

mTOR and S6K1 mediate assembly of the translation preinitiation complex through dynamic protein interchange and ordered phosphorylation events

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3104746

Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3104746

Disruption of the mouse mTOR gene leads to early postimplantation lethality and prohibits embryonic stem cell development

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3104746

Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3104746

mTOR is essential for growth and proliferation in early mouse embryos and embryonic stem cells

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3104746

The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3104746

Insulin-like growth factor binding protein 2 (IGFBP-2) separates hypertrophic and hyperplastic effects of growth hormone (GH)/IGF-I excess on adrenocortical cells in vivo

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3104746

A new method for large scale isolation of kidney glomeruli from mice

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3104746

Diabetic nephropathy: pathogenesis, diagnosis, and prevention of progression.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3104746

Regulation of cellular growth by the Drosophila target of rapamycin dTOR

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3104746

The sizes of renal glomeruli in fetuses and infants

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3104746

The pathophysiology of protein-overload proteinuria.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3104746

Role of growth hormone in the development of experimental renal scarring

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3104746

Glomerular size and structure in diabetes mellitus. I. Early abnormalities

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3104746

Tubular epithelial cell and podocyte apoptosis with de novo sirolimus based immunosuppression in renal allograft recipients with DGF.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3104746

Rapamycin has dual opposing effects on proteinuric experimental nephropathies: is it a matter of podocyte damage?

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3104746

The mTOR pathway is highly activated in diabetic nephropathy and rapamycin has a strong therapeutic potential.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3104746

Diabetic kidney lesions of GIPRdn transgenic mice: podocyte hypertrophy and thickening of the GBM precede glomerular hypertrophy and glomerulosclerosis

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3104746

The Notch pathway in podocytes plays a role in the development of glomerular disease

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3104746

Inhibition of mTOR signaling with rapamycin attenuates renal hypertrophy in the early diabetic mice

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3104746

Post-transplantation proteinuria and sirolimus

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3104746

Podocyte hypertrophy, "adaptation," and "decompensation" associated with glomerular enlargement and glomerulosclerosis in the aging rat: prevention by calorie restriction.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3104746

Podocyte-specific expression of cre recombinase in transgenic mice

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3104746

Drosophila S6 kinase: a regulator of cell size

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3104746

Mammalian Target of Rapamycin Pathway Blockade Slows Progression of Diabetic Kidney Disease in Rats

26 November 2018

1 reference

12 December 2020

Deletion of protein kinase C-beta isoform in vivo reduces renal hypertrophy but not albuminuria in the streptozotocin-induced diabetic mouse model

1 reference

12 December 2020

Renoprotective effects of sirolimus in non-immune initiated focal segmental glomerulosclerosis

1 reference

12 December 2020

High sirolimus levels may induce focal segmental glomerulosclerosis de novo

1 reference

12 December 2020

Quantitative gene expression analysis in renal biopsies: a novel protocol for a high-throughput multicenter application

1 reference

12 December 2020

The unbiased estimation of number and sizes of arbitrary particles using the disector

1 reference

12 December 2020

Stereological estimates of volume-weighted mean glomerular volume in streptozotocin-diabetic rats

1 reference

12 December 2020

Large juxtamedullary glomeruli and afferent arterioles in healthy primates

1 reference

12 December 2020

A principle for counting tissue structures on random sections

1 reference

12 December 2020

Heparan sulfate of perlecan is involved in glomerular filtration

1 reference

12 December 2020

Determinants of Glomerular Volume in Different Cortical Zones of the Human Kidney

1 reference

12 December 2020

Role of podocytes in focal sclerosis: defining the point of no return

1 reference

12 December 2020

Identifiers

DOI

10.1172/JCI44774

1 reference

13 October 2017

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13 October 2017

PubMed publication ID

21606591

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