Many neuronal and behavioral impairments in transgenic mouse models of Alzheimer's disease are independent of caspase cleavage of the amyloid precursor protein (Q30499149)

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English	Many neuronal and behavioral impairments in transgenic mouse models of Alzheimer's disease are independent of caspase cleavage of the amyloid precursor protein	scientific article

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scholarly article

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Europe PubMed Central

PMC publication ID

19 October 2017

Many neuronal and behavioral impairments in transgenic mouse models of Alzheimer's disease are independent of caspase cleavage of the amyloid precursor protein (English)

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Europe PubMed Central

PMC publication ID

19 October 2017

Alzheimer's disease

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inferred from title

Eliezer Masliah

8

object named as

Eliezer Masliah

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Europe PubMed Central

19 October 2017

PMC publication ID

9

object named as

Lennart Mucke

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Europe PubMed Central

PMC publication ID

19 October 2017

author name string

Julie A Harris

1

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Europe PubMed Central

PMC publication ID

19 October 2017

Nino Devidze

2

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Europe PubMed Central

PMC publication ID

19 October 2017

Brian Halabisky

3

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Europe PubMed Central

PMC publication ID

19 October 2017

Iris Lo

4

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Europe PubMed Central

PMC publication ID

19 October 2017

Myo T Thwin

5

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Europe PubMed Central

PMC publication ID

19 October 2017

Gui-Qiu Yu

6

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19 October 2017

Dale E Bredesen

7

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Europe PubMed Central

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19 October 2017

language of work or name

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publication date

1 January 2010

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Europe PubMed Central

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19 October 2017

Journal of Neuroscience

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Europe PubMed Central

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19 October 2017

30

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Europe PubMed Central

PMC publication ID

19 October 2017

1

1 reference

Europe PubMed Central

PMC publication ID

19 October 2017

372-381

1 reference

Europe PubMed Central

PMC publication ID

19 October 2017

Reversal of learning deficits in hAPP transgenic mice carrying a mutation at Asp664: a role for early experience

1 reference

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20 June 2018

Mechanism of cytotoxicity mediated by the C31 fragment of the amyloid precursor protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064502

20 June 2018

Neurodegeneration in Alzheimer's disease: caspases and synaptic element interdependence

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064502

20 June 2018

Neprilysin overexpression inhibits plaque formation but fails to reduce pathogenic Abeta oligomers and associated cognitive deficits in human amyloid precursor protein transgenic mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064502

20 June 2018

APP binds DR6 to trigger axon pruning and neuron death via distinct caspases

1 reference

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20 June 2018

Epilepsy and cognitive impairments in Alzheimer disease

1 reference

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20 June 2018

Cystatin C-cathepsin B axis regulates amyloid beta levels and associated neuronal deficits in an animal model of Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064502

20 June 2018

The amyloid precursor protein intracellular domain (AICD) as modulator of gene expression, apoptosis, and cytoskeletal dynamics-relevance for Alzheimer's disease

1 reference

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20 June 2018

Long-term prevention of Alzheimer's disease-like behavioral deficits in PDAPP mice carrying a mutation in Asp664.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064502

20 June 2018

Enkephalin elevations contribute to neuronal and behavioral impairments in a transgenic mouse model of Alzheimer's disease

1 reference

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20 June 2018

Dendritic spine loss and synaptic alterations in Alzheimer's disease.

1 reference

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20 June 2018

Soluble oligomers of the amyloid beta-protein impair synaptic plasticity and behavior

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064502

20 June 2018

Aberrant excitatory neuronal activity and compensatory remodeling of inhibitory hippocampal circuits in mouse models of Alzheimer's disease

1 reference

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20 June 2018

Reducing endogenous tau ameliorates amyloid beta-induced deficits in an Alzheimer's disease mouse model

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064502

20 June 2018

A beta oligomers - a decade of discovery

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064502

20 June 2018

100 years and counting: prospects for defeating Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064502

20 June 2018

Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064502

20 June 2018

Reversal of Alzheimer's-like pathology and behavior in human APP transgenic mice by mutation of Asp664.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064502

20 June 2018

Abeta induces cell death by direct interaction with its cognate extracellular domain on APP (APP 597-624)

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064502

20 June 2018

Early-onset behavioral and synaptic deficits in a mouse model of Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064502

20 June 2018

A specific amyloid-beta protein assembly in the brain impairs memory

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064502

20 June 2018

Vulnerability of dentate granule cells to disruption of arc expression in human amyloid precursor protein transgenic mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064502

20 June 2018

Behavioral phenotypes of amyloid-based genetically modified mouse models of Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064502

20 June 2018

Aspects of spatial memory and behavioral disinhibition in Tg2576 transgenic mice as a model of Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064502

20 June 2018

Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064502

20 June 2018

Neuronal depletion of calcium-dependent proteins in the dentate gyrus is tightly linked to Alzheimer's disease-related cognitive deficits

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064502

20 June 2018

Neuronal deficiency of presenilin 1 inhibits amyloid plaque formation and corrects hippocampal long-term potentiation but not a cognitive defect of amyloid precursor protein [V717I] transgenic mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064502

20 June 2018

The gamma -secretase-cleaved C-terminal fragment of amyloid precursor protein mediates signaling to the nucleus

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064502

20 June 2018

Measuring normal and pathological anxiety-like behaviour in mice: a review.

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20 June 2018

High-level neuronal expression of abeta 1-42 in wild-type human amyloid protein precursor transgenic mice: synaptotoxicity without plaque formation

1 reference

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20 June 2018

A second cytotoxic proteolytic peptide derived from amyloid beta-protein precursor

1 reference

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20 June 2018

Involvement of caspases in proteolytic cleavage of Alzheimer's amyloid-beta precursor protein and amyloidogenic A beta peptide formation

1 reference

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20 June 2018

Plaque-independent disruption of neural circuits in Alzheimer's disease mouse models

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20 June 2018

Early phenotypic changes in transgenic mice that overexpress different mutants of amyloid precursor protein in brain

1 reference

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20 June 2018

Proteolytic processing of the Alzheimer's disease amyloid precursor protein within its cytoplasmic domain by caspase-like proteases.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064502

20 June 2018

Amyloid precursor protein processing and A beta42 deposition in a transgenic mouse model of Alzheimer disease

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Protection against HIV-1 gp120-induced brain damage by neuronal expression of human amyloid precursor protein

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Physical basis of cognitive alterations in Alzheimer's disease: Synapse loss is the major correlate of cognitive impairment

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Accelerating amyloid-beta fibrillization reduces oligomer levels and functional deficits in Alzheimer disease mouse models.

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Neuroprotective effects of regulators of the glycogen synthase kinase-3beta signaling pathway in a transgenic model of Alzheimer's disease are associated with reduced amyloid precursor protein phosphorylation.

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064502

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Deficits in synaptic transmission and learning in amyloid precursor protein (APP) transgenic mice require C-terminal cleavage of APP.

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26 November 2018

Fyn kinase induces synaptic and cognitive impairments in a transgenic mouse model of Alzheimer's disease.

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Dendrite and dendritic spine alterations in Alzheimer models

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26 November 2018

Fyn kinase modulates synaptotoxicity, but not aberrant sprouting, in human amyloid precursor protein transgenic mice.

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26 November 2018

A short cytoplasmic domain of the amyloid precursor protein induces apoptosis in vitro and in vivo.

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beta-Secretase cleavage of the amyloid precursor protein mediates neuronal apoptosis caused by familial Alzheimer's disease mutations

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26 November 2018

Age-related impairment of synaptic transmission but normal long-term potentiation in transgenic mice that overexpress the human APP695SWE mutant form of amyloid precursor protein.

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Impairments in learning and memory accompanied by neurodegeneration in mice transgenic for the carboxyl-terminus of the amyloid precursor protein

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12 December 2020

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10.1523/JNEUROSCI.5341-09.2010

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Europe PubMed Central

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19 October 2017

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Europe PubMed Central

PMC publication ID

19 October 2017

PubMed publication ID

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Europe PubMed Central

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19 October 2017

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