Phase II trial of CoQ10 for ALS finds insufficient evidence to justify phase III. (Q30494108)

16 September 2017

Phase II trial of CoQ10 for ALS finds insufficient evidence to justify phase III. (English)

1 reference

amyotrophic lateral sclerosis

16 September 2017

phase II clinical trial

0 references

phase III clinical trial

0 references

1 reference

inferred from title

author

Terry Heiman-Patterson

object named as

Terry Heiman-Patterson

1 reference

16 September 2017

Catherine Lomen-Hoerth

object named as

Catherine Lomen-Hoerth

1 reference

16 September 2017

Hiroshi Mitsumoto

1 reference

16 September 2017

Petra Kaufmann

1 reference

16 September 2017

John L P Thompson

1 reference

16 September 2017

Gilberto Levy

1 reference

16 September 2017

Richard Buchsbaum

1 reference

16 September 2017

Jeremy Shefner

1 reference

16 September 2017

Lisa S Krivickas

1 reference

16 September 2017

Jonathan Katz

1 reference

16 September 2017

Yvonne Rollins

1 reference

16 September 2017

Richard J Barohn

1 reference

16 September 2017

Carlayne E Jackson

1 reference

16 September 2017

Ezgi Tiryaki

1 reference

16 September 2017

Carmel Armon

1 reference

16 September 2017

Rup Tandan

1 reference

16 September 2017

Stacy A Rudnicki

1 reference

16 September 2017

Kourosh Rezania

1 reference

16 September 2017

Robert Sufit

1 reference

16 September 2017

Alan Pestronk

1 reference

16 September 2017

Steven P Novella

1 reference

16 September 2017

Edward J Kasarskis

1 reference

16 September 2017

Erik P Pioro

1 reference

16 September 2017

Jacqueline Montes

1 reference

16 September 2017

Rachel Arbing

1 reference

16 September 2017

Darleen Vecchio

1 reference

16 September 2017

Alexandra Barsdorf

1 reference

16 September 2017

Bruce Levin

1 reference

16 September 2017

QALS Study Group

1 reference

16 September 2017

1 August 2009

1 reference

16 September 2017

1 reference

16 September 2017

1 reference

16 September 2017

1 reference

16 September 2017

235-244

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Nutrition and dietary supplements in motor neuron disease

16 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2854625

Adaptive clinical trials: progress and challenges

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2854625

Oxidative stress biomarkers in sporadic ALS

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2854625

Genetics of familial amyotrophic lateral sclerosis

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2854625

The role of Coenzyme Q in mitochondrial electron transport

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2854625

Clinical trials of coenzyme Q10 in neurological disorders

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2854625

A responsive outcome for Parkinson's disease neuroprotection futility studies

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2854625

Vitamin E intake and risk of amyotrophic lateral sclerosis

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2854625

High dose vitamin E therapy in amyotrophic lateral sclerosis as add-on therapy to riluzole: results of a placebo-controlled double-blind study

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2854625

ALS issues in clinical trials. Missing data

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2854625

High throughput drug screening

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2854625

Pilot trial of high dosages of coenzyme Q10 in patients with Parkinson's disease

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2854625

Effects of Coenzyme Q10 in Huntington's disease and early Parkinson's disease

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2854625

Effects of coenzyme Q10 in early Parkinson disease: evidence of slowing of the functional decline

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2854625

Cu/Zn superoxide dismutase (SOD1) mutations associated with familial amyotrophic lateral sclerosis (ALS) affect cellular free radical release in the presence of oxidative stress

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2854625

Coenzyme Q10 as a possible treatment for neurodegenerative diseases

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2854625

Biochemical functions of coenzyme Q10

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2854625

El Escorial revisited: revised criteria for the diagnosis of amyotrophic lateral sclerosis

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2854625

Dietary coenzyme Q10 and vitamin E alter the status of these compounds in rat tissues and mitochondria

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2854625

Coenzyme Q10 administration increases brain mitochondrial concentrations and exerts neuroprotective effects

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2854625

Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2854625

Changes in the normal maximal expiratory flow-volume curve with growth and aging

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2854625

The MOS 36-ltem Short-Form Health Survey (SF-36)

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2854625

Increased mitochondrial oxidative damage and oxidative DNA damage contributes to the neurodegenerative process in sporadic amyotrophic lateral sclerosis

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2854625

Excellent inter‐rater, intra‐rater, and telephone‐administered reliability of the ALSFRS‐R in a multicenter clinical trial

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2854625

A two-stage design for a phase II clinical trial of coenzyme Q10 in ALS.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2854625

26 November 2018

The utility of futility.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2854625

Proteomic analysis of 4-hydroxy-2-nonenal-modified proteins in G93A-SOD1 transgenic mice--a model of familial amyotrophic lateral sclerosis

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2854625

The ALSFRSr predicts survival time in an ALS clinic population

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2854625

An increase of oxidized coenzyme Q-10 occurs in the plasma of sporadic ALS patients

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2854625

Increased lipid peroxidation in sera of ALS patients: a potential biomarker of disease burden

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2854625

A randomized, placebo-controlled trial of topiramate in amyotrophic lateral sclerosis

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2854625

An outcome study of riluzole in amyotrophic lateral sclerosis--a population-based study in Ireland, 1996-2000.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2854625

Mitochondrial electron transport chain complex dysfunction in a transgenic mouse model for amyotrophic lateral sclerosis

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2854625

Mitochondrial DNA and respiratory chain function in spinal cords of ALS patients

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2854625

The ALSFRS-R: a revised ALS functional rating scale that incorporates assessments of respiratory function. BDNF ALS Study Group (Phase III).

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2854625

Incidence and prevalence of ALS in Ireland, 1995-1997: a population-based study

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2854625

Performance of the Amyotrophic Lateral Sclerosis Functional Rating Scale (ALSFRS) in multicenter clinical trials

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2854625

Onset, natural history and outcome in idiopathic adult motor neuron disease

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2854625

Effect of coenzyme Q(10) and alpha-tocopherol content of mitochondria on the production of superoxide anion radicals

26 November 2018

1 reference

12 December 2020

Amyotrophic lateral sclerosis in Olmsted County, Minnesota, 1925 to 1998

1 reference

12 December 2020

The fatigue severity scale. Application to patients with multiple sclerosis and systemic lupus erythematosus

1 reference

12 December 2020

Incidence and prevalence of amyotrophic lateral sclerosis in Harris County, Texas, 1985-1988

1 reference

12 December 2020

Dose-ranging study of riluzole in amyotrophic lateral sclerosis. Amyotrophic Lateral Sclerosis/Riluzole Study Group II

1 reference

12 December 2020

A carbon column-based liquid chromatography electrochemical approach to routine 8-hydroxy-2'-deoxyguanosine measurements in urine and other biologic matrices: a one-year evaluation of methods

1 reference

12 December 2020

Applying a phase II futility study design to therapeutic stroke trials

1 reference

12 December 2020

Tolerance of high-dose (3,000 mg/day) coenzyme Q10 in ALS

1 reference

12 December 2020

Increased mitochondrial oxidative damage in patients with sporadic amyotrophic lateral sclerosis

1 reference

12 December 2020

Identifiers

DOI

10.1002/ANA.21743

1 reference

16 September 2017

1 reference

16 September 2017

PubMed publication ID

19743457

1 reference