Time-resolved mechanism of extracellular gate opening and substrate binding in a glutamate transporter (Q30484136)

16 November 2017

Time-resolved mechanism of extracellular gate opening and substrate binding in a glutamate transporter (English)

1 reference

16 November 2017

Ivet Bahar

0 references

author name string

Indira H Shrivastava

series ordinal

1 reference

16 November 2017

Jie Jiang

series ordinal

1 reference

16 November 2017

Susan G Amara

series ordinal

1 reference

16 November 2017

language of work or name

English

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publication date

4 August 2008

1 reference

Journal of Biological Chemistry

16 November 2017

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16 November 2017

283

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16 November 2017

1 reference

16 November 2017

28680-28690

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Dynamic personalities of proteins

16 November 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2568915

Intrinsic dynamics of enzymes in the unbound state and relation to allosteric regulation

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2568915

Aspartate-444 is essential for productive substrate interactions in a neuronal glutamate transporter

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2568915

Glutamate and monoamine transporters: new visions of form and function

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2568915

Cooperation of the conserved aspartate 439 and bound amino acid substrate is important for high-affinity Na+ binding to the glutamate transporter EAAC1

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2568915

The glutamate-activated anion conductance in excitatory amino acid transporters is gated independently by the individual subunits

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2568915

Coupling substrate and ion binding to extracellular gate of a sodium-dependent aspartate transporter

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2568915

Implications of the quaternary twist allosteric model for the physiology and pathology of nicotinic acetylcholine receptors

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2568915

Common mechanism of pore opening shared by five different potassium channels

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2568915

Neutralization of the aspartic acid residue Asp-367, but not Asp-454, inhibits binding of Na+ to the glutamate-free form and cycling of the glutamate transporter EAAC1.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2568915

Structural changes involved in protein binding correlate with intrinsic motions of proteins in the unbound state

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2568915

Coarse-grained normal mode analysis in structural biology

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2568915

Individual subunits of the glutamate transporter EAAC1 homotrimer function independently of each other

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2568915

Crystal structure of a bacterial homologue of Na+/Cl--dependent neurotransmitter transporters

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2568915

Coupling between catalytic site and collective dynamics: a requirement for mechanochemical activity of enzymes

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2568915

Usefulness and limitations of normal mode analysis in modeling dynamics of biomolecular complexes

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2568915

Small-scale molecular motions accomplish glutamate uptake in human glutamate transporters

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2568915

Structure of a glutamate transporter homologue from Pyrococcus horikoshii

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2568915

A trimeric quaternary structure is conserved in bacterial and human glutamate transporters

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2568915

Gating of MscL Studied by Steered Molecular Dynamics

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2568915

The Xplor-NIH NMR molecular structure determination package

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2568915

Excitatory amino acid transporters: keeping up with glutamate.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2568915

Energetics of glycerol conduction through aquaglyceroporin GlpF.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2568915

Early intermediates in the transport cycle of the neuronal excitatory amino acid carrier EAAC1

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2568915

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2568915

Glutamate translocation of the neuronal glutamate transporter EAAC1 occurs within milliseconds

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2568915

Homology modeling and molecular dynamics simulation studies of an inward rectifier potassium channel

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2568915

Isolation of current components and partial reaction cycles in the glial glutamate transporter EAAT2.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2568915

Simulations of ion permeation through a potassium channel: molecular dynamics of KcsA in a phospholipid bilayer

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2568915

A conserved serine-rich stretch in the glutamate transporter family forms a substrate-sensitive reentrant loop

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2568915

Two serine residues of the glutamate transporter GLT-1 are crucial for coupling the fluxes of sodium and the neurotransmitter

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2568915

Molecular determinant of ion selectivity of a (Na+ + K+)-coupled rat brain glutamate transporter

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2568915

Flux coupling in a neuronal glutamate transporter

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2568915

Essential dynamics of proteins

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2568915

An excitatory amino-acid transporter with properties of a ligand-gated chloride channel

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2568915

Simple Allosteric Model for Membrane Pumps

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2568915

Ion fluxes associated with excitatory amino acid transport.

20 June 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M800889200

Proximity of two oppositely oriented reentrant loops in the glutamate transporter GLT-1 identified by paired cysteine mutagenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M800889200

GROMACS: A message-passing parallel molecular dynamics implementation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M800889200

Voltage-independent sodium-binding events reported by the 4B-4C loop in the human glutamate transporter excitatory amino acid transporter 3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M800889200

Anion currents and predicted glutamate flux through a neuronal glutamate transporter.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2568915

The accessibility of a novel reentrant loop of the glutamate transporter GLT-1 is restricted by its substrate

26 November 2018

1 reference

12 December 2020

A model for the topology of excitatory amino acid transporters determined by the extracellular accessibility of substituted cysteines

1 reference

12 December 2020

Arginine 447 plays a pivotal role in substrate interactions in a neuronal glutamate transporter

1 reference

12 December 2020

Mutation of an amino acid residue influencing potassium coupling in the glutamate transporter GLT-1 induces obligate exchange

1 reference

12 December 2020

A reentrant loop domain in the glutamate carrier EAAT1 participates in substrate binding and translocation

1 reference

12 December 2020

Investigating a back door mechanism of actin phosphate release by steered molecular dynamics

1 reference

12 December 2020

Multiple consequences of mutating two conserved beta-bridge forming residues in the translocation cycle of a neuronal glutamate transporter

1 reference

12 December 2020

Structural rearrangements at the translocation pore of the human glutamate transporter, EAAT1

1 reference

12 December 2020

A comprehensive structure-based alignment of prokaryotic and eukaryotic neurotransmitter/Na+ symporters (NSS) aids in the use of the LeuT structure to probe NSS structure and function

1 reference

12 December 2020

The glutamate and chloride permeation pathways are colocalized in individual neuronal glutamate transporter subunits

1 reference

12 December 2020

Identifiers

DOI

10.1074/JBC.M800889200

1 reference

16 November 2017

1 reference

16 November 2017

PubMed publication ID

18678877

1 reference