Molecular basis of vitamin E action: tocotrienol modulates 12-lipoxygenase, a key mediator of glutamate-induced neurodegeneration (Q30479718)

15 October 2017

Molecular basis of vitamin E action: tocotrienol modulates 12-lipoxygenase, a key mediator of glutamate-induced neurodegeneration (English)

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15 October 2017

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15 October 2017

Hoon Ryu

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15 October 2017

Savita Khanna

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15 October 2017

Sashwati Roy

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15 October 2017

Praveen Bahadduri

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15 October 2017

Rajiv R Ratan

series ordinal

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15 October 2017

Chandan K Sen

series ordinal

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15 October 2017

language of work or name

English

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publication date

13 August 2003

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Journal of Biological Chemistry

15 October 2017

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inferred from page(s)

published in

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15 October 2017

278

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15 October 2017

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15 October 2017

43508-43515

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Tyrphostins protect neuronal cells from oxidative stress

15 October 2017

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Specificity of resistance to oxidative stress

20 June 2018

1 reference

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Oxidant-induced vascular endothelial growth factor expression in human keratinocytes and cutaneous wound healing

20 June 2018

1 reference

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Oxytosis: A novel form of programmed cell death

20 June 2018

1 reference

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Glutathione metabolism in brain metabolic interaction between astrocytes and neurons in the defense against reactive oxygen species

20 June 2018

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Glutathione, oxidative stress and neurodegeneration

20 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1910692

Cellular and mitochondrial changes in glutamate-induced HT4 neuronal cell death

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1910692

Molecular basis of vitamin E action. Tocotrienol potently inhibits glutamate-induced pp60(c-Src) kinase activation and death of HT4 neuronal cells

20 June 2018

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Vitamin E: function and metabolism

20 June 2018

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The regulation of reactive oxygen species production during programmed cell death

20 June 2018

1 reference

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The structure of mammalian 15-lipoxygenase reveals similarity to the lipases and the determinants of substrate specificity

20 June 2018

1 reference

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Protection against glutamate-induced cytotoxicity in C6 glial cells by thiol antioxidants

20 June 2018

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A role for 12-lipoxygenase in nerve cell death caused by glutathione depletion.

20 June 2018

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Glutamate toxicity on a PC12 cell line involves glutathione (GSH) depletion and oxidative stress

20 June 2018

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Vitamin E in humans: demand and delivery

20 June 2018

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Automated docking of flexible ligands: applications of AutoDock

20 June 2018

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Crystal structure of soybean lipoxygenase L-1 at 1.4 A resolution

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1910692

Tyrosine kinase activity modulates catalysis and translocation of cellular 5-lipoxygenase

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1910692

Antioxidant effects of tocotrienols in patients with hyperlipidemia and carotid stenosis

20 June 2018

1 reference

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Arachidonate 12-lipoxygenase is localized in neurons, glial cells, and endothelial cells of the canine brain

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1910692

Structural and dynamic membrane properties of alpha-tocopherol and alpha-tocotrienol: implication to the molecular mechanism of their antioxidant potency

20 June 2018

1 reference

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Vulnerability of oligodendroglia to glutamate: pharmacology, mechanisms, and prevention

20 June 2018

1 reference

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Vitamin E: beyond antioxidant function

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1910692

Neurones express high levels of a structurally modified, activated form of pp60c-src

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1910692

Neurochemical, neurophysiological, and neuropathological studies in vitamin E deficiency

20 June 2018

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Methods for antagonizing glutamate neurotoxicity

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1910692

Immature cortical neurons are uniquely sensitive to glutamate toxicity by inhibition of cystine uptake

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1910692

Localization of arachidonate 12-lipoxygenase in canine brain tissues

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1910692

Hypocholesterolemic activity of synthetic and natural tocotrienols

20 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1910692

Mammalian lipoxygenases: molecular structures and functions

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1910692

A mechanism for glutamate toxicity in the C6 glioma cells involving inhibition of cystine uptake leading to glutathione depletion

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1910692

Regulation of glucose transport and GLUT1 glucose transporter expression by O2 in muscle cells in culture

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1910692

The Protein Data Bank. A computer-based archival file for macromolecular structures

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1910692

Oxidative glutamate toxicity can be a component of the excitotoxicity cascade.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1910692

Src deficiency or blockade of Src activity in mice provides cerebral protection following stroke

26 November 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1910692

Studies of LDL oxidation following alpha-, gamma-, or delta-tocotrienyl acetate supplementation of hypercholesterolemic humans.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1910692

Shape and specificity in mammalian 15-lipoxygenase active site. The functional interplay of sequence determinants for the reaction specificity.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1910692

Lipoic acid increases de novo synthesis of cellular glutathione by improving cystine utilization

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1910692

Role of glutathione metabolism in the glutamate-induced programmed cell death of neuronal-like PC12 cells.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1910692

Antioxidant properties of alpha-tocopherol and alpha-tocotrienol

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1910692

Comparative antioxidant activity of tocotrienols and other natural lipid-soluble antioxidants in a homogeneous system, and in rat and human lipoproteins

26 November 2018

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12 December 2020

Activity and protein distribution of 12-lipoxygenase in HEL cells: induction of membrane-association by phorbol ester TPA, modulation of activity by glutathione and 13-HPODE, and Ca(2+)-dependent translocation to membranes

1 reference

12 December 2020

Inhibitors of cholesterol biosynthesis. 2. Hypocholesterolemic and antioxidant activities of benzopyran and tetrahydronaphthalene analogues of the tocotrienols

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12 December 2020

Inhibition of protein kinase C activity and vascular smooth muscle cell growth by d-alpha-tocopherol

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12 December 2020

Vitamin E: a sensor and an information transducer of the cell oxidation state

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12 December 2020

Neurodegenerative disorders in humans: the role of glutathione in oxidative stress-mediated neuronal death

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12 December 2020

Quantitation of Arachidonic Acid Metabolites in Small Tissue Biopsies by Reversed-Phase High-Performance Liquid Chromatography

1 reference

12 December 2020

Simultaneous detection of tocopherols and tocotrienols in biological samples using HPLC-coulometric electrode array

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12 December 2020

New aspects of the inhibition of soybean lipoxygenase by alpha-tocopherol. Evidence for the existence of a specific complex

1 reference

12 December 2020

Inhibition of 5-lipoxygenase by vitamin E

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12 December 2020

Role of vitamin E in neural tissue

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12 December 2020

Identifiers

DOI

10.1074/JBC.M307075200

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15 October 2017

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15 October 2017

PubMed publication ID

12917400

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