Stoichiometry based steady-state hepatic flux analysis: computational and experimental aspects (Q30437950)

13 October 2017

Stoichiometry based steady-state hepatic flux analysis: computational and experimental aspects (English)

1 reference

13 October 2017

0 references

John Mattick

1 reference

13 October 2017

Mehmet A Orman

1 reference

13 October 2017

Ioannis P Androulakis

series ordinal

1 reference

13 October 2017

Francois Berthiaume

series ordinal

1 reference

13 October 2017

Marianthi G Ierapetritou

series ordinal

1 reference

13 October 2017

14 March 2012

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13 October 2017

1 reference

13 October 2017

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13 October 2017

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13 October 2017

268-291

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Creative Commons Attribution 4.0 International

13 October 2017

start time

14 March 2012

1 reference

April 2022 Public Data File from Crossref

copyrighted

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cites work

Generation of oxygen gradients in microfluidic devices for cell culture using spatially confined chemical reactions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3901202

The hepatitis B e antigen suppresses IL-1β-mediated NF-κB activation in hepatocytes

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3901202

Feeding cues and injected nutrients induce acute expression of multiple clock genes in the mouse liver

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3901202

Strategies for extended serum half-life of protein therapeutics

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3901202

The dynamics of the early inflammatory response in double-hit burn and sepsis animal models

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3901202

Metabolic response of perfused livers to various oxygenation conditions

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3901202

Inflammation, Oxidative Stress, and Obesity

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3901202

Endothelial dysfunction in hypertension: The role of arginase

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3901202

Metabolic Profiling Based Quantitative Evaluation of Hepatocellular Metabolism in Presence of Adipocyte Derived Extracellular Matrix

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3901202

The role of circadian timing system on drug metabolism and detoxification

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3901202

HepatoNet1: a comprehensive metabolic reconstruction of the human hepatocyte for the analysis of liver physiology

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3901202

Computational reconstruction of tissue‐specific metabolic models: application to human liver metabolism

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3901202

Soft constraints-based multiobjective framework for flux balance analysis

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3901202

Effects of glucose and insulin on HepG2-C3A cell metabolism

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3901202

Arginase: an emerging key player in the mammalian immune system

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3901202

Microchip electrophoresis with chemiluminescence detection for assaying ascorbic acid and amino acids in single cells

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3901202

MouseCyc: a curated biochemical pathways database for the laboratory mouse

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3901202

Effects of drugs in subtoxic concentrations on the metabolic fluxes in human hepatoma cell line Hep G2.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3901202

A rational design approach for amino acid supplementation in hepatocyte culture

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3901202

Elementary mode analysis: a useful metabolic pathway analysis tool for characterizing cellular metabolism

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3901202

Group contribution method for thermodynamic analysis of complex metabolic networks

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3901202

In vivo mitochondrial oxygen tension measured by a delayed fluorescence lifetime technique

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3901202

Identification of metabolic fluxes in hepatic cells from transient 13C-labeling experiments: Part I. Experimental observations

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3901202

Cytochrome p450 and chemical toxicology

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3901202

Application of metabolic flux analysis to identify the mechanisms of free fatty acid toxicity to human hepatoma cell line

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3901202

Microfluidic devices for size-dependent separation of liver cells

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3901202

Structural and functional analysis of cellular networks with CellNetAnalyzer

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3901202

Thermodynamics-based metabolic flux analysis

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3901202

Contribution of gene expression to metabolic fluxes in hypermetabolic livers induced through burn injury and cecal ligation and puncture in rats

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3901202

Quantitative elementary mode analysis of metabolic pathways: the example of yeast glycolysis

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3901202

20 June 2018

Bacterial Collagenase.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3901202

Study of hepatocyte differentiation using embryonic stem cells

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3901202

In vitro zonation and toxicity in a hepatocyte bioreactor

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3901202

Profiling of dynamic changes in hypermetabolic livers

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3901202

Two approaches for metabolic pathway analysis?

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3901202

Xenobiotic metabolism by cultured primary porcine hepatocytes

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3901202

Theory for the systemic definition of metabolic pathways and their use in interpreting metabolic function from a pathway-oriented perspective

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3901202

Zonation of parenchymal and nonparenchymal metabolism in liver

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3901202

Culture medium composition affects the relative toxicities of chlorobenzenes in rat liver slices and the isolated perfused liver.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3901202

Zonation of metabolism and gene expression in liver.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3901202

Primary hepatocyte culture: substratum requirements and production of matrix components

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3901202

Collagen substrata for studies on cell behavior

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3901202

In vivo administration of purified human interleukin 2. I. Half-life and immunologic effects of the Jurkat cell line-derived interleukin 2.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3901202

The isolated perfused rat liver: conceptual and practical considerations

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3901202

Hepatocyte heterogeneity in response to icosanoids. The perivenous scavenger cell hypothesis

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3901202

Functional specialization of different hepatocyte populations

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3901202

Zonation of fatty acid metabolism in rat liver

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3901202

Effects of dimethyl sulfoxide on cultured rat hepatocytes in sandwich configuration

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3901202

Hepatocyte heterogeneity in the metabolism of fatty acids: discrepancies on zonation of acetyl-CoA carboxylase

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3901202

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3901202

Hepatocyte Heterogeneity in the Metabolism of Amino Acids and Ammonia

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3901202

Liver Cell Heterogeneity: Functions of Non-Parenchymal Cells

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3901202

Influence of viability on bromosulfophthalein uptake by isolated hepatocytes

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3901202

Isolation and characterization of hepatocytes and Kupffer cells

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3901202

Induction of trytophan oxygenase by dexamethasome in isolated hepatocytes dependence on composition of medium and pH

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3901202

Chapter 4 Preparation of Isolated Rat Liver Cells

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3901202

Stimulation of adenylate cyclase from isolated hepatocytes and Kupffer cells

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3901202

Effects of dehydroepiandrosterone administration on rat hepatic metabolism following thermal injury

20 June 2018

1 reference

https://api.crossref.org/works/10.3390%2FMETABO2010268

Evolution of intrahepatic carbon, nitrogen, and energy metabolism in a D-galactosamine-induced rat liver failure model

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMETABO2010268

Intrahepatic amino acid and glucose metabolism in a D-galactosamine-induced rat liver failure model

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMETABO2010268

Metabolic flux determination in perfused livers by mass balance analysis: effect of fasting

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMETABO2010268

Acoustic accessibility investigation for ultrasound mediated treatment of glycogen storage disease type Ia patients

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMETABO2010268

Growth factors and nonparenchymal cell conditioned media induce mitogenic responses in stable long-term adult rat hepatocyte cultures

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMETABO2010268

Improvement of rat liver graft quality by pifithrin-alpha-mediated inhibition of hepatocyte necrapoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMETABO2010268

Microfluidic-based measurements of cytochrome P450 enzyme activity of primary mammalian hepatocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMETABO2010268

Bile canaliculi formation by aligning rat primary hepatocytes in a microfluidic device

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMETABO2010268

Liver-specific functional studies in a microfluidic array of primary mammalian hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMETABO2010268

An artificial liver sinusoid with a microfluidic endothelial-like barrier for primary hepatocyte culture

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMETABO2010268

Metabolic flux analysis of cultured hepatocytes exposed to plasma

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMETABO2010268

Application of multivariate analysis to optimize function of cultured hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMETABO2010268

Identification of distributed metabolic objectives in the hypermetabolic liver by flux and energy balance analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMETABO2010268

Pathway analysis of liver metabolism under stressed condition

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMETABO2010268

Investigation of metabolic objectives in cultured hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMETABO2010268

Analysis of amino acid supplementation effects on hepatocyte cultures using flux balance analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMETABO2010268

Effects of amino acid transport limitations on cultured hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMETABO2010268

Novel quantitative tools for engineering analysis of hepatocyte cultures in bioartificial liver systems

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMETABO2010268

Integrated energy and flux balance based multiobjective framework for large-scale metabolic networks

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMETABO2010268

FluxAnalyzer: exploring structure, pathways, and flux distributions in metabolic networks on interactive flux maps

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMETABO2010268

Identification of flux regulation coefficients from elementary flux modes: A systems biology tool for analysis of metabolic networks

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMETABO2010268

A quadratic programming approach for decomposing steady-state metabolic flux distributions onto elementary modes

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMETABO2010268

Maximum entropy decomposition of flux distribution at steady state to elementary modes

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMETABO2010268

Transcriptional and metabolic flux profiling of triadimefon effects on cultured hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMETABO2010268

Modular decomposition of metabolic reaction networks based on flux analysis and pathway projection

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMETABO2010268

Metabolic network analysis of perfused livers under fed and fasted states: incorporating thermodynamic and futile-cycle-associated regulatory constraints

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMETABO2010268

Metabolic flux analysis of hepatocyte function in hormone- and amino acid-supplemented plasma

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMETABO2010268

Sleep and circadian rhythm regulate circulating complement factors and immunoregulatory properties of C5a.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMETABO2010268

Phenylalanine hydroxylase expression in primary rat hepatocytes is modulated by oxygen concentration

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMETABO2010268

Norepinephrine modulates the zonally different hepatocyte proliferation through the regulation of transglutaminase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMETABO2010268

Gluconeogenesis and the Cori cycle in 12-, 20-, and 40-h-fasted humans

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3901202

Role of serum in maintenance of functional hepatocytes in primary culture

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3901202

Effects of decreased glutamine supply on gut and liver metabolism in vivo in rats

26 November 2018

1 reference

12 December 2020

Mass flux balance-based model and metabolic flux analysis for collagen synthesis in the fibrogenesis process of human liver

1 reference

12 December 2020

Functional activity of isolated perfused rat liver depends on medium composition

1 reference

12 December 2020

Metabolic flux analysis of postburn hepatic hypermetabolism

1 reference

12 December 2020

Effect of burn injury on glucose and nitrogen metabolism in the liver: preliminary studies in a perfused liver system

1 reference

12 December 2020

Dynamics of liver glycogen: the topochemistry of glycogen synthesis, glycogen content and glycogenolysis under the experimental conditions of glycogen accumulation and depletion

1 reference

12 December 2020

Use of an artificial oxygen carrier in isolated rat liver perfusion: first demonstration of net glucose uptake at physiological portal glucose concentrations using a hemoglobin-free perfusate

1 reference

12 December 2020

1 reference

12 December 2020

Development of an optimal method for the dual perfusion of the isolated rat liver

1 reference

12 December 2020

Limitations of the mass isotopomer distribution analysis of glucose to study gluconeogenesis. Substrate cycling between glycerol and triose phosphates in liver

1 reference

12 December 2020

Identifiers

DOI

10.3390/METABO2010268

1 reference

13 October 2017

1 reference

13 October 2017

PubMed publication ID

24957379

1 reference